A 2006 Cochrane Collaboration review of controlled trials of antipsychotics in old age dementia reported that one or two of the drugs showed a modest benefit compared to placebo in managing aggression or psychosis, but that this was combined with a significant increase in serious adverse events.

The 2011 figures show an increase of some 64, 000 speakers compared to the 2006 figures to 714, 136, with significant increases in the Autonomous Community but a slight drop in the Northern Basque Country to 51, 100, overall amounting to an increase to 27 % of all inhabitants of Basque provinces ( 2, 648, 998 in total ).

The 2005 census showed a significant increase, as this figure reached 230, 600 inhabitants.

These tests met with “ partial success ” in the gathering of data, and led, therefore, to a significant increase in research dollars in fiscal year 1962 to conduct additional research in these areas.

Intel's successor to the P5 architecture, P6, added superscalar capabilities to its floating point features, and therefore afforded a significant increase in floating point instruction performance.

In the 1980s and 1990s there was a significant increase in passenger transport on the roads in the Czech Republic, which was associated with a sharp increase in the accident rate.

Breeding experiments in Germany with poodles, coyotes, and later on with the resulting dog-coyote hybrids showed that, unlike wolfdogs, coydogs exhibit a decrease in fertility, significant communication problems, and an increase of genetic diseases after three generations of interbreeding.

The replacement of the Roman saddle by variants on the Scythian model, with pommel and cantle, was also a significant factor as was the adoption of stirrups and the concomitant increase in stability of the rider's seat.

By contrast, loop diuretics promote a significant increase calcium excretion.

In a follow-up study, Swiss children showed a significant increase in sharing between the ages of 3 and 8.

Although the administration made progress on such issues as taking state responsibility for past human rights cases and supporting human rights in international fora, it failed to show significant advances on combating impunity in past human rights cases, military reforms, a fiscal pact to help finance peace implementation, and legislation to increase political participation.

These factors can also cause hydrocodone and related drugs to have a threshold effect, cause significant lengthening or shortening of the duration of effects in the absence of tolerance, and increase or decrease the de facto conversion ratio between hydrocodone and other drugs like morphine, hydromorphone, and synthetics like levorphanol and methadone.

During the period 1813-1913, there was a significant increase in worker wages.

The results showed that, unlike wolf-dog hybrids, jackal-dog hybrids show a decrease in fertility, significant communication problems, and an increase of genetic disorders after three generations of interbreeding, much like coydogs.

The lack of manpower also led to a significant increase in the number of " barbarians " in the Byzantine armies after the early 540s.

During his reign, there was a significant increase in the size of the Mughal Empire, half a dozen rebellions were crushed, prisoners of war were released, and the work of his father, Akbar, continued to flourish.

The baby boom saw a significant increase in sales for Jello.

Since the war, Kuwait, with the help of the United States and other allies, has made significant efforts to increase the size and modernity of their armed forces.

" The authors further report a " significant increase in the speed of mathematical processing, with no reduction in accuracy " following the administration of a 300 mg dose.

The study also found a small, but statistically significant, increase in unemployment for adults aged 20 – 24.

There is a very significant increase of Web users in Malawi.

* 1980s-1990s: EPZ expanded and led to a significant increase in foreign direct investment ( FDI ) and tourism.

Palin's travel programmes are responsible for a phenomenon termed the " Palin effect ": areas of the world that he has visited suddenly become popular tourist attractions – for example, the significant increase in the number of tourists interested in Peru after Palin visited Machu Picchu.

The agricultural sector continues to employ a significant proportion of the labor force.

Although reconstruction has proceeded quickly with significant aid from the international community, tourism and agricultural activities remain weak and nearly offset the stimulus from the reconstruction boom.

This network would have enabled easy access by road to the neighbouring countries of Brazil, Venezuela and Surinam ; reduced the costs of utilising the country's timber and natural resources, thus making them more competitive in international markets ; diversified agricultural development by making more easily available suitable areas in the hinterland, particularly in the Intermediate and Rupununi savannahs ; relieved the over-crowded coastland of a significant proportion of its population, thus improving the quality of life of the inhabitants of both the coastal and interior areas ; and made more feasible the equitable distribution of economic activity, not only in the agricultural but also in the manufacturing and small-industries sector.

With the completion of the port at Haifa and its oil refineries, significant industry was added to the predominantly agricultural Palestinian economy.

The most significant areas of friction involve trucking, sugar, high fructose corn syrup, and a number of other agricultural products.

This restoration of agriculture was supported by credit policy of the government, helping both individual farmers and large privatized corporate farms, that once were Soviet kolkhozes and still own the significant share of agricultural land.

The state's economy centres on the agricultural, manufacturing and mining industries and has an increasingly significant finance sector as well.

The Rio Guadalquivir is one of the most significant rivers in Spain because it irrigates a fertile valley, thus creating a rich agricultural area, and because it is navigable inland, making Seville the only inland river port for ocean-going traffic in Spain.

On the one hand, agricultural funds the Common Agricultural Policy of the European Union ( CAP ) is spread across more countries ( the Eastern Europe countries have a significant agricultural sector ), on the other, the structural and cohesion funds have declined inevitably due to the Spanish economic success ( since their income has progressed strongly in absolute terms ) and due to the incorporation of less developed countries, lowers the average income per capita ( or GDP per capita ), so that Spanish regions relatively less developed, have come to be in the European average or even above it.

The issue divided Ireland, for a significant unionist minority ( largely though by no means exclusively based in Ulster ), opposed Home Rule, fearing that a Catholic-Nationalist parliament in Dublin would discriminate against them and would also impose tariffs on industry ; while most of Ireland was primarily agricultural, six counties in Ulster were the location of heavy industry and would be affected by any tariff barriers imposed.

Areas around the southern part of Lake Maracaibo are swampy, and, despite the rich agricultural land and significant petroleum deposits, the area was still thinly populated in 1990.

However, the Venetian empire was a major exporter of agricultural products and, until the mid-18th century, a significant manufacturing center.

A significant product of these improved iron-smelting techniques was the manufacture of new agricultural tools.

Its expanded agricultural output helped sustain Qin's large army with food and natural resources ; the Wei River canal built in 246 BC was particularly significant in this respect.

The 11th century marked a significant boom in the region's economy, due to improved trading and, mostly, agricultural conditions.

A study by Prof. Shaw has criticized a century of scholarly literature which theorizes a long decline in agricultural conditions since ancient times due to destructive invasions and significant climate change ; Shaw writes that such theories may be based on " false assumptions about the past, dubious literary evidence, and misunderstood archaeological data.

This has had a significant effect on Norway's agricultural policy, which has been reshaped to address population patterns rather than self-sufficiency.

Farmers are often members of local, regional, or national farmers ' unions or agricultural producers ' organizations and can exert significant political influence.

Chania was chosen as the seat of the Rector ( Administrator General ) of the region and flourished as a significant commercial centre of a fertile agricultural region.

By 1940, counties that had experienced the most significant levels of erosion saw a greater decline in agricultural land values.

The good news is, however, that the majority of experts believe that significant reductions in net greenhouse gas emissions are technically feasible due to an extensive array of technologies and policy measures in the energy supply, energy demand and agricultural and forestry sectors.

Traditionally an agricultural society, by the 1970s the country had undergone significant industrialization and economic modernization.

The agricultural sector still suffered from inconsistent water supplies and a lack of significant long term storage.