Shamans have historically been well known throughout the world to mix two or more of some of the listed substances to produce synergistic effects.

While the use of paracetamol, aspirin, ibuprofen, naproxen and other NSAIDS concurrently with weak to mid-range opiates ( up to about the hydrocodone level ) has been said to show beneficial synergistic effects by combatting pain at multiple sites of action, several combination analgesic products have been shown to have few efficacy benefits when compared to similar doses of their individual components.

The relative importance and interactions between these different antioxidants is a very complex question, with the various metabolites and enzyme systems having synergistic and interdependent effects on one another.

With its four arms attached with a combination of different active agents, for example, iRNA ( for gene silencing ), microRNA ( for gene expression regulation ), aptamer ( for targeting ) and ribozyme ( as catalyst ), the X-shaped RNA can achieve therapeutic and diagnostic functions by regulating gene expression and cellular function, and binding to cancer cells with precision, enhanced by its polyvalent nature and synergistic effects by design.

Penicillin shows a synergistic effect with aminoglycosides, since the inhibition of peptidoglycan synthesis allows aminoglycosides to penetrate the bacterial cell wall more easily, allowing their disruption of bacterial protein synthesis within the cell.

Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers.

TIDES will integrate its component capabilities with one another and with other technologies to produce synergistic, effective, end-to-end, technology demonstration systems able to address multiple real-world applications.

Some species of mushrooms have been found to contain multiple antiviral chemicals with similar synergistic effects.

In 2011, researchers suggested that " extant marine invertebrates face the same synergistic effects of multiple stressors " that occurred during the end-Permian extinction, and that genera " with poorly buffered respiratory physiology and calcareous shells ", such as corals, were particularly vulnerable.

What emerges from these philosophies, in the view of Hu, is a country with systematic approach to national structure and development that combines dynamic economic growth, a free market energized by a vigorous " nonpublic " ( i. e., private ) sector, heavy-handed political and media control, personal but not political freedoms, concern for the welfare of all citizens, cultural enlightenment, and a synergistic approach to diverse social issues ( the Scientific Development Perspective ) that lead, in Hu ’ s vision, to a " Harmonious Society ".

It is strongly advised to use metalaxyl along with carbamate compounds, or the especially effective synergistic Cymoxanil and Mancozeb combination as it is effective at managing metalaxyl resistant strains.

When administered alone sulfonamides are not efficacious in treating malaria but co-administration with the antifolate pyrimethamine, most commonly as fixed-dose sulfadoxine-pyrimethamine ( Fansidar ), produces synergistic effects sufficient to cure sensitive strains of malaria.

Another technology, thermotherapy, uses radio-frequency energy to directly heat the bladder wall, which together with chemotherapy shows a synergistic effect, enhancing each other's capacity to kill tumor cells.

Though no further research has been done as of yet, it may also be involved with disrupted NMDA channels in the brain, which have both synergistic and regulatory effects on norepinephrine.

From the latter part of the 18th century, charges of antinomianism were frequently directed against Calvinists, primarily by Arminian Methodists, who subscribed to a synergistic soteriology that contrasted with Calvinism's monergistic doctrine of justification.

The brachioradialis is synergistic with the brachialis and biceps brachii ; the triceps brachii and anconeus are antagonistic.

When iota carrageenan is combined with sodium stearoyl lactylate ( SSL ), a synergistic effect is created, allowing for stabilizing and emulsifying not obtained with any other type of carrageenan ( kappa / lambda ) or with other emulsifiers ( mono and diglycerides, etc .).

The combination also causes synergistic enhancement of the disinhibitory and amnesic effects of both drugs, with potentially embarrassing or criminal consequences.

On 7 May 1557 he was appointed professor of New Testament theology at Jena but was soon involved in controversy with his colleague Victorinus Strigel on the synergistic question ( relating to the function of the will in conversion ).

They have a highly synergistic effect in concert with auxins, and the ratios of these two groups of plant hormones affect most major growth periods during a plant's lifetime.

PIM shares considerable, potentially synergistic overlap with disciplines such as cognitive science, human-computer interaction, information science, artificial intelligence, database management and information retrieval.

Kertész and other Hungarian artists formed a synergistic circle ; he was featured in exhibits with some of them later in his life.

Cellulase action is considered to be synergistic as all three classes of cellulase can yield much more sugar than the addition of all three separately.

It was concluded that larger foundresses are more reproductively fit and thus JH, which is responsible for the growth and maturation of the ovaries, be more active within these individuals compared to the smaller, less fertile foundresses though the mechanism of action and / or any synergistic effects between JH and other hormones remains unknown.

According to the Synergism Hypothesis, synergistic effects have been the drivers of cooperative relationships of all kinds and at all levels in living systems.

French standard NF E 01-010 gives the following definition: “ approach aiming at the synergistic integration of mechanics, electronics, control theory, and computer science within product design and manufacturing, in order to improve and / or optimize its functionality ".

Mikkyō is a little-understood, yet often sensationalised, synergistic “ esoteric construct ” that lies at the very core of Japanese spirituality and mysticism.

The relationship is synergistic, with the customer having early ( and sometimes unique, or at least uniquely early ) access to an advantageous new product or technology, but he also serves as a kind of guinea pig.

* Epiroprim and dapsone are synergistic when used in combination ( in vitro studies only at present )

Upon consideration of the variety of soils and fabrics normally encountered in the washing process, it is little wonder that the use of a number of detergent constituents having `` synergistic '' properties has gained widespread acceptance.

How indigenous peoples discovered the synergistic properties of the plants used in the ayahuasca brew remains unclear.

Wild-type p53 is a labile protein, comprising folded and unstructured regions that function in a synergistic manner.

Where Simpson relied upon a synergistic interaction between genetic drift and a shift in the adaptive fitness landscape, Eldredge and Gould relied upon ordinary speciation, particularly Ernst Mayr's concept of allopatric speciation.

In the natural world, synergistic phenomena are ubiquitous, ranging from physics ( for example, the different combinations of quarks that produce protons and neutrons ) to chemistry ( a popular example is water, a compound of hydrogen and oxygen ), to the cooperative interactions among the genes in genomes, the division of labor in bacterial colonies, the synergies of scale in multi-cellular organisms, as well as the many different kinds of synergies produced by socially-organized groups, from honeybee colonies to wolf packs and human societies.

Even the tools and technologies that are widespread in the natural world represent important sources of synergistic effects.

The thesis, in a nutshell, is that synergistic effects have often provided functional advantages ( economic benefits ) in relation to survival and reproduction that have been favored by natural selection.

In such cases, it is said that the parasites in combination have a synergistic effect.

Walt Disney pioneered synergistic marketing techniques in the 1930s by granting dozens of firms the right to use his Mickey Mouse character in products and ads, and continued to market Disney media through licensing arrangements.

" Along that same thought, Arthur Koestler stated, " it is the synergistic effects produced by wholes that are the very cause of the evolution of complexity in nature " and used the metaphor of Janus ( a symbol of the unity underlying complements like open / shut, peace / war ) to illustrate how the two perspectives ( strong or holistic vs. weak or reductionistic ) should be treated as perspectives, not exclusives, and should work together to address the issues of emergence.

And this is equally true of the synergistic effects produced by emergent systems.

The most significant risk is synergistic, because the E2 component follows a small fraction of a second after the first component's insult, which has the ability to impair or destroy many protective and control features.

The NIH's research is divided into two parts: the NIH Extramural Research Program is responsible for the funding of biomedical research outside the NIH, while the NIH Intramural Research Program ( IRP ) is the internal research program of the NIH, known for its synergistic approach to biomedical science.

This is called a synergistic interaction.

Stone ’ s avuncular and supportive manner and his ability as an educator and designer created a synergistic office environment that fostered design inquiry and experimentation.

Thus, it functions as a synergistic partner to insulin.