Although major concerns about benzodiazepine tolerance and withdrawal have been raised, there is no evidence for significant dose escalation in patients using benzodiazepines long-term.

Although they are second-line agents, benzodiazepines can be used for a limited time to relieve severe anxiety and agitation.

Although they lack the chemical structure of the benzodiazepines, their sedative effect is similarly through action on the GABAA receptor.

Although there is little evidence for benefit of benzodiazepines in insomnia and evidence of major harm, prescriptions have continued to increase.

Although a distinguishing characteristic of a benzodiazepine is that the withdrawal effects clearly may protract in course for an inordinate amount of time, iatrogenic dependence ( doctor induced ) can be an overlooked phenomenon with benzodiazepines.

Although he questions the extent and nature of the alleged revival of religion and the alleged increase in conformity, and thinks that `` hedonistic '' present-time orientation does not have the meaning usually attributed to it, he does conclude that Americans increasingly enjoy leisure without guilt, do not stress achievement so much as formerly, are more accepting of group harmony as a goal, more tolerant of diversity and aware of other cultures.

Although the false glamour surrounding bourbon or other whisky commercials is possibly no more fatuous than the pseudo-sophistication with which TV soft-drinks are downed or toothpaste applied, there is a sad difference between enticing a viewer into sipping Oopsie-Cola and gulling him into downing bourbon.

Although the United States and the U.S.S.R. have been arguing whether there shall be four, five or six top assistants, the most important element in the situation is not the number of deputies but the manner in which these deputies are to do their work.

Although today's trucks are as fast as passenger cars, a truck driver has to be a sensible person and guard against hogging the road.

Although they are forbidden to sit with the customers, the dancers are sometimes proffered drinks, and most of them can bolt one down in mid-shimmy.

Although there are many sound reasons for adopting uniform and coordinated fiscal years in Rhode Island, there are also certain difficulties encountered.

Although the site may not contain the features themselves, there are often opportunities to include them as additional interest to the site.

Although the play does show a certain structural amateurishness ( there are eleven acts varying in length from twenty-five seconds to an hour and a half ), the statement it makes concerning the ceaseless yearning and searching of youth is profound and worthy of our attention.

Although there is no question but that the process of washing fabrics involves a number of phenomena which are related together in an extremely complicated way and that these phenomena and their interrelations are not well understood at the present, this section attempts to present briefly an up-to-date picture of the physical chemistry of washing either fabrics or hard surfaces.

Although the standard deviation values on which spread of the lines is based are relatively larger for those centers which begin to ossify early ( Table 1 ), there are considerable differences in this value between centers having the closely timed Onsets.

Although in both emotions sympathetic symptoms are present, different autonomic-somatic patterns underlie aggression and anxiety, respectively, as indicated by the rate of the excretion of the catecholamines, the state of the muscle tone, and the Mecholyl test.

Although we are still far from a complete understanding of these problems, as a first approximation, it is suggested that alterations in the hypothalamic balance with consequent changes in the hypothalamic-cortical discharges account for major changes in behavior seen in various moods and states of emotions in man and beast under physiological circumstances, in experimental and clinical neurosis, and as the result of psychopharmacological agents.

Although the inner functions of religion are not of direct significance in social organization, they have important indirect consequences.

Although the Brandywine population is still predominantly rural, `` there are indications of a consistent and a statistically significant trend away from the older and relatively isolated rural communities.

Although science has given us more effective materials, preparations from anise, castorbean, colchicum, nux vomica, mustard, fennel, and stramonium are familiar to many for the relief of human ailments.

Although the Administration's program cut crop acreage to the lowest point since 1934, farmers, with the help of extra fertilizer and good weather, are getting such high yields per acre that many are being forced to buy new harvesting machines.

Although progress has been made in America's system of libraries it still falls short of what is required if we are to maintain the standards that are needed for an informed America.

Although the theological forms of the past continue to exist in a way they do not in a more secularized situation, the striking thing is the rapidity with which they are being reduced to a marginal existence.

Although there are landscapes in the show ( one of the strongest is a vista of `` Gloucester Harbor '' in 1915 ), the human element was the compelling factor in Sloan's art.

Although after much trouble he did manage to get it back, he discovered there was no trade to be had.

Although the wood has been changed to coal, much of it still retains its original cell structure.

Although much of the Industrial Division's promotional effort is devoted to securing new locations and expansions by major industries, small business is also afforded considerable attention.

Although not much desiring the account, he had been appointed advertising head of Zenith.

Although his respect for Aristotle was diminished as his travels made it clear that much of Aristotle's geography was clearly wrong, when the old philosopher released his works to the public, Alexander complained " Thou hast not done well to publish thy acroamatic doctrines ; for in what shall I surpass other men if those doctrines wherein I have been trained are to be all men's common property?

Although Albert Johnston was born in Kentucky, he lived much of his life in Texas, which he considered his home.

Although much of Inge's principles, above, still apply to the New Agrarianism, the affiliation with a particular religion and patriarchal tendency have subsided to some degree.

Although much of the church hierarchy in the East had opposed the Nicene creed in the decades leading up to Theodosius ' accession, he managed to achieve unity on the basis of the Nicene creed.

Although relatively large for a theropod, Albertosaurus was much smaller than its more famous relative Tyrannosaurus, probably weighing less than 2 metric tons.

Although not mentioned by Asser or by the Anglo-Saxon Chronicle, Alfred probably also paid the Vikings cash to leave, much as the Mercians were to do in the following year.

Although such a conversion can be prone to loss, most modern audio systems use this approach as the techniques of digital signal processing are much more powerful and efficient than analog domain signal processing.

Although these churches hold much in common, their theology differs on whether the intermediate state is unconscious sleep or consciousness, whether the ultimate punishment of the wicked is annihilation or eternal torment, the nature of immortality, whether or not the wicked are resurrected after the millennium, and whether the sanctuary of refers to the one in heaven or one on earth.

Although the Carthaginians conquered much of the land around Alicante, the Romans would eventually rule Hispania Tarraconensis for over 700 years.

Although the Umayyads did not have a historical presence in the region ( no member of the Umayyad family was known to have ever set foot in al-Andalus before ) and there were grave concerns about young Abd al-Rahman's inexperience, several of the lower-ranking Yemenite commanders felt they had little to lose and much to gain, and agreed to support the prince.

Although most legislation is initiated by the executive branch, the Bundestag considers the legislative function its most important responsibility, concentrating much of its energy on assessing and amending the government's legislative program.

Although this shift was an important one, it did not represent a radical break from the past so much as a small step in a broader, more gradual socio-economic movement that had been going on at least since 1907 when van de Velde had argued for a craft basis for design while Hermann Muthesius had begun implementing industrial prototypes.

Although Benedictines do not take a vow of silence, hours of strict silence are set, and at other time silence is maintained as much as is practically possible.

Although the Orioles hovered around. 500 for much of the season, they had fallen back by September and were over 20 games behind the first place Tampa Bay Rays.

Although The Tale of Pigling Bland was not published until 1930, it had been written much earlier.

Although BJU has an unranked and untenured faculty, most University employees consider their positions as much ministries as jobs.

Although the Nationalists had an advantage in numbers of men and weapons, initially controlled a much larger territory and population than their adversaries, and enjoyed considerable international support, they were exhausted by the long war with Japan and the attendant internal responsibilities.

Although much of Chad's distinctiveness comes from this diversity of influences, since independence the diversity has also been an obstacle to the creation of a national identity.

Although much of the watershed is rural and sparsely populated, areas with recreational and scenic values are growing rapidly.