Although single genes have little effect on complex traits and interact heavily both between themselves and with the external factors, research is underway to unravel possible molecular mechanisms underlying anxiety and comorbid conditions.

Although the hardware is limited to four separate sound channels, software such as OctaMED uses software mixing to allow eight or more virtual channels, and it was possible for software to mix two hardware channels to achieve a single 14-bit resolution channel by playing with the volumes of the channels in such a way that one of the source channels contributes the most significant bits and the other the least.

Although " Takes A Little Time " was a moderate hit single, the album failed to sell like the previous two albums, which had both gone multi-platinum.

Although BR was a single entity, it was divided into six ( later five ) regional authorities in accordance with the existing areas of operation.

Although his success lasted only a year and a half before his death in an airplane crash, Holly is described by critic Bruce Eder as " the single most influential creative force in early rock and roll.

Although there is no strong evidence for any single theory, many independent theories exist, some blaming storms, some capsizing, and some suggesting that wartime enemy activity was to blame for the loss.

" Although based on a simplistic analysis of internal strife in Greece and Turkey, it became the single dominating influence over U. S. policy until at least the Vietnam War.

Although some say Judaism is noncreedal in nature, others say it recognizes a single creed, the Shema Yisrael, which begins: " Hear, O Israel: the LORD our God, the LORD is one.

Although the two parts are now normally published as a single work, Don Quixote, Part Two was a sequel published ten years after the original novel.

Although bacteriophages were first described in 1927, it was only in 1959 that Sinshemer working with phage Phi X 174 showed that they could possess single stranded DNA genomes.

Although the track was edited out of the final cut, it would later be re-recorded and released as " Safe " on the B-side of Bowie's 2002 single " Everyone Says ' Hi '".

Although many of the results in Elements originated with earlier mathematicians, one of Euclid's accomplishments was to present them in a single, logically coherent framework, making it easy to use and easy to reference, including a system of rigorous mathematical proofs that remains the basis of mathematics 23 centuries later.

Although it never uses the term, The Church of Jesus Christ of Latter-day Saints ( The Mormon Church ) is episcopal, rather than presbyterian or congregational, in the sense that it has a strict hierarchy of leadership from the local bishop up to a single prophet / president, believed to be personally authorized and guided by Jesus Christ.

Although there are important differences between them, all of them were materialists who believed that the world was made up of a single substance, matter, the motions and properties of which could be used to explain all phenomena.

Although its file format also allows for multiple such streams to be concatenated ( zipped files are simply decompressed concatenated as if they were originally one file ), gzip is normally used to compress just single files.

Although turret presses operate much like single stage presses, they eliminate much of the setup time required in positioning individual dies correctly.

" Although it was a single sentence in a 461-page book, reviewers focused on it.

Although the school was a single institution, it was divided into two parts: a grammar school called the collège or schola privata and an advanced school called the académie or schola publica.

Although a single EPSP was not enough to fire an action potential in the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron could cause the motor neuron to fire, thus contracting the quadriceps.

Although he is often characterized as an " architect " exclusively, as James Beck has observed, " to single out one of Leon Battista's ' fields ' over others as somehow functionally independent and self-sufficient is of no help at all to any effort to characterize Alberti's extensive explorations in the fine arts.

Although they reign under constitutions, the monarchs of Brunei, Oman, Qatar, Saudi Arabia and Swaziland appear to continue to exercise more political influence than any other single source of authority in their nations, either by constitutional mandate or by tradition.

Although the term " metallic bond " is often used in contrast to the term " covalent bond ", it is preferable to use the term metallic bonding, because this type of bonding is collective in nature and a single " metallic bond " does not exist.

Although four songs were released as singles to promote the album ( lead single " Everything I Need ", " Man With Two Hearts ", " Maria ", and " Hard Luck Story "), only the first song charted in the US, and that only at No. 47.

Although they do share commonalities, contemporary Pagan religious movements are diverse and no single set of beliefs, practices, or texts are shared by them all.

Although the economy was booming in the region, the business struggled and Lincoln eventually sold his share.

Although the team has been sold to Los Angeles investor Mark Attanasio, questions remain regarding Selig's past involvement.

Although only two copies of the collection of poetry were sold, the sisters continued writing for publication and began their first novels, continuing to use their noms de plume when sending manuscripts to potential publishers.

Although not a huge seller, 142 LINK-8s were sold starting at $ 38, 500.

Although most users did not purchase the registered version, over one million copies have been sold, and the popularity helped the sales of later games in the Doom series that were not released as shareware.

Although the sisters were told several months after publication that only two copies had sold, they were not discouraged.

Although the first edition sold out within a year, Calvin was dissatisfied with its structure as a catechism, a primer for young Christians.

Although Esau sold Jacob his own birthright, which was his blessing, for " red pottage ", Esau still hated Jacob for receiving his blessing that their father Isaac unknowingly had given to him.

Although the property was sold in 1922, the reconstructed structure remained in its serene setting.

Although Christians, both Western and Eastern, were by law prohibited from being sold into slavery, the native Christians were often indistinguishable from the Muslim population and the Italian merchants were sometimes accused of selling them along with Muslim slaves.

Although about half of that money was spent on CPUs used in desktop or laptop personal computers, those count for only about 2 % of all CPUs sold.

Although meteorites had been sold commercially and collected by hobbyists for many decades, up to the time of the Saharan finds of the late 1980s and early 1990s, most meteorites were deposited in or purchased by museums and similar institutions where they were exhibited and made available for scientific research.

Although originally from New Jersey, wax-wrapped salt water taffy is a popular item sold in tourist areas.

Although it never sold in the numbers Fuhrmann envisioned, the 928 developed an avid fan following and enjoyed an eighteen year production run.

Although DPS was written in conjunction with NeXT, Adobe sold it commercially and it was a common feature of most Unix workstations in the 1990s.

Although a small number of Rickenbacker acoustics were sold in the 1950s and were seen in the hands of stars like Ricky Nelson and Sam Cooke, the company concentrated on their electric guitar and western steel guitar business from the early 1960s onward.

" Although this does not render them totally illegal ( they may still, for example, be used on private property ), their uses are limited enough that they are not sold to the general public.

Although the Orange Bowl was sold out for the event, unconditional blackout rules in the NFL prohibited the live telecast from being shown in the Miami area.

Although Tulane Stadium was sold out for the game, unconditional blackout rules in the NFL prohibited the live telecast from being shown in the New Orleans area.

Although sold as a thriller in the mould of McGoohan's previous series, Danger Man ( US: Secret Agent ), the show's combination of 1960s countercultural themes and surreal setting had a far-reaching effect on science fiction / fantasy programming, and on popular culture in general.

Although the book had been selling well before the trial, once Carlile was arrested and charged, 4, 000 copies were sold in just a few months.

Although Harding desired to run for a second term in office, he may have been aware of his own health decline ; he gave up drinking, sold his " life-work ", the Marion Star, in part to regain $ 170, 000 previous investment losses, and had the U. S. Attorney General Harry Daugherty make a new will.

Although very significant in terms of its influence on future system design, it is deemed a failure because it only sold approximately 25, 000 units.

Although the submarine was repaired and eventually carried out several trial runs in lower New York Harbor, by the end of 1886 the Nautilus Submarine Boat Company was no more, and the salvageable remnants of the Zalinski Boat were sold to reimburse the disappointed investors.