TYR encodes tyrosinase, which is not a component of the immune system, but is an enzyme of the melanocyte that catalyzes melanin biosynthesis, and a major autoantigen in generalized vitiligo.

Non-collagenous domain basement membrane collagen type IV is autoantigen ( target antigen ) of autoantibodies in the autoimmune disease Goodpasture's syndrome.

To establish that a disorder is an autoimmune disorder, Witebsky criteria requires that there be ( 1 ) a self-reactive antibody, ( 2 ) that a particular target for the antibody is identified ( autoantigen ) ( 3 ) that the disorder can be caused in animals and ( 4 ) that transferring antibodies from one animal to another triggers the disorder ( passive transfer ).

α-fodrin functions as an autoantigen in Sjögren's syndrome.

Specifically, M. tuberculosis blocks the bridging molecule, early endosomal autoantigen 1 ( EEA1 ); however, this blockade does not prevent fusion of vesicles filled with nutrients.

The word `` mimesis '' ( `` imitation '' ) is usually associated with Plato and Aristotle.

The party is usually in a room small enough so that all guests are within sight and hearing of one another.

It will readily be seen that in this suggested network ( not materially different from some of the networks in vogue today ) greater emphasis on monitoring is implied than is usually put into practice.

One is so accustomed to think of men as the privileged who need but ask and receive, and women as submissive and yielding, that our sympathies are usually enlisted on the side of the man whose love is not returned, and we condemn the woman as a coquette.

usually, this is most exasperating to men, who expect every woman to verify their preconceived notions concerning her sex, and when she does not, immediately condemn her as eccentric and unwomanly.

What evidence is available would seem to indicate that Brooks, unlike his older brother Henry, had most of the methodological vices usually found in the amateur.

He is usually something of an underdog, he must battle the organized police force as well as recognized criminals.

he usually draws some kind of comparison with the jazz tradition and the poem he is reading -- for instance, he draws the parallel between a poem he reads about an Oriental courtesan waiting for the man she loves, and who never comes, and the old blues chants of Ma Rainy and other Negro singers -- but usually the comparison is specious.

This is a common symptom and the cause usually is pressure on the nerve leading to the affected hand.

if the Government certifies that production may be possible from the property, the royalty obligation continues for the 10-year period usually specified in the contract or until the Government's contribution is repaid with interest.

These roads are largely of less than highway standards, and usually carry traffic which is related to use of the National Forests.

April 15 is usually the final date for filing income tax returns for most people because they use the calendar year ending on December 31.

Much of this necessary increase in research and development, though properly chargeable to current expenses, is not reflected in earnings until projects are completed and the new machines sold in quantity, usually over a period of several years.

Sometimes it is necessary to roughly calculate the square inch area of the opening but the calculation can usually be made with sufficient accuracy that it won't affect the final computation.

Enough daylight is usually available from the windows, but if you have synchronized flash -- use it.

The size of the press is usually expressed in terms of chuck capacity ( the maximum diameter tool shank it will hold ) or distance between the spindle center and the column.

We know now that a 15-degree differential in temperature is the maximum usually desirable, and accurate controls assure the comfort we want.

It is usually helpful to make a sketch map in the field, showing the size and location of the features of interest and to take photographs at the site.

A body of water is usually the center of interest at parks which attract the greatest picnic and camping use.

`` I may possibly be a greater risk than is the normal person of my age '', the President had said on February 29th of the election year, ignoring the fact that no one of his age had ever lived out another term.

It is good to know that Georgia will continue to have sufficient electrical power not only to meet the demands of normal growth but to encourage a more rapid rate of industrialization.

Fortunately, there is a nursery school which he has been able to attend, with a group of normal children.

`` I try to treat Daniel as if he were normal, though of course I realize he is far from that at present.

At the head of the CDC is an unorthodox, 39-year-old amateur politico, Thomas B. Carvey Jr., whose normal profession is helping develop Hughes Aircraft's moon missiles.

These problems frequently arise where a firm is making items for the Government not directly along the lines of its normal civilian business or where the Government specifications require operations that the firm did not understand when it undertook the contract.

This is a normal governmental procedure which reflects more accurately cost-accounting principles.

By this scheme, pulling one signal to clear locks all the other switch and signal levers in safe positions until the first signal is again restored to normal.

A tire must be inflated to its normal hot operating pressure and the car must be loaded to its operating weight when this measurement is made.

A cross-section of a normal lower human leg is shown in Fig. 8 with the various parts labeled.

The concept of the strain energy as a Gibbs function difference Af and exerting a force normal to the shearing face is compatible with the information obtained from optical birefringence studies of fluids undergoing shear.

Af appeared to be well suited for the study of these matters, since it is a normal paramagnet, with three unpaired electrons on the chromium, its crystal structure is very simple, and the unknown position of the hydrogen in the strong Af bond provides structural interest.

The Af layers are stacked normal to the ( 111 ) axis with the lower oxygens of one layer directly above the upper oxygens of the neighboring lower layer, in such a manner that the repeat is every three layers.

The bond angles and distances are all within the expected limits and the volume per oxygen is about normal.

It is very unlikely that either of these anacondas was growing at a normal rate.

the former figure is based on a somewhat unusual birth of four by a Central American female ( see chapter on Laying, Brooding, Hatching, and Birth ), the latter on a `` normal '' newly born individual.

In man the normal level of iodine in the diet and the level necessary to prevent development of goitre is about 100 **ymg per day.

In the presence of a low iodine intake, thyroglobulin labelled in vivo with Af is found to contain more mono-iodotyrosine than normal, the amounts of di-iodotyrosine and iodothyronines being correspondingly reduced.

Second, what is its concentration in normal circumstances and in what circumstances will this concentration depart from the normal level and in which direction??

Whether this abnormal TSH differs chemically from pituitary TSH, or is, alternatively, normal TSH with its period of effectiveness modified by some other blood constituent, cannot be decided without chemical study of the activity in the blood of these patients and a comparison of the substance responsible for the blood activity with pituitary Aj.

In both conditions the emotional and perceptual sensitivity is diminished, but no depression occurs such as is seen clinically or may be produced in normal persons by drugs.