By using instruments of gradually increasing size, the vagina is gently, and with minimum pain at each stage, taught to yield to an object of the appropriate shape.

By 1980, the way the game was played had changed dramatically due to innovative coaching tactics, with the phasing out of many of the game's kicking styles and the increasing use of handball ; whilst presentation was influenced by television.

By the 18th century an increasing number of new plants had arrived in Europe from newly discovered countries and the European colonies worldwide and a larger number of plants became available for study.

By the early twentieth century, both parties were winning increasing numbers of seats in Congress.

By 1967, however, Frei encountered increasing opposition from leftists, who charged that his reforms were inadequate, and from conservatives, who found them excessive.

By the early 1970s, the picture changed: software costs were dramatically increasing, a growing software industry was competing with the hardware manufacturer's bundled software products ( free in that the cost was included in the hardware cost ), leased machines required software support while providing no revenue for software, and some customers able to better meet their own needs did not want the costs of " free " software bundled with hardware product costs.

By the end of the war, turbojet engines were replacing piston engines as the means of propulsion, further increasing their speed.

By packing opposition voters into districts they will already win ( increasing excess votes for winners ) and by cracking the remainder among districts where they are moved into the minority ( increasing votes for eventual losers ), the number of wasted votes among the opposition can be maximized.

By increasing the concentration of oxygen in the air, the effects of lower barometric pressure are countered and the level of arterial pO < sub > 2 </ sub > is restored toward normal capacity.

By the Middle Bronze Age, increasing numbers of smelted iron objects ( distinguishable from meteoric iron by the lack of nickel in the product ) appeared in the Middle East, Southeast Asia, and South Asia.

By increasing this distance, larger tires can be installed, which will increase the ground clearance, allowing it to traverse even larger and more difficult obstacles.

By 1914, experiments were being conducted with guns in increasing sizes up to 51 cm.

By the mid-18th century there was an increasing number of proposals to create a public gallery, with the art critic La Font de Saint-Yenne publishing, in 1747, a call for a display of the royal collection '.

By working sloppily, the unskilled workers may drag down the average skill of labor, thus increasing the average labor time necessary for the production of each unit commodity.

By the assumptions of increasing marginal costs, exogenous inputs ' prices, and control concentrated on a single agent or entrepreneur, the optimal decision is to equate the marginal cost and marginal revenue of production.

By 1944 US and British air forces were sending huge air fleets over occupied Europe, increasing the pressure on the Luftwaffe day and night fighter forces.

By 1905 it was known that the energy of photoelectrons increases with increasing frequency of incident light and is independent of the intensity of the light.

By overblowing, that is, increasing the pressure of breath and tension of lips, odd harmonics ( notes whose frequencies are odd-number multiples of the fundamental ), near a 12th in cylindrical tubes, may also be produced.

By adding an intercooler, increasing compression to 8. 5: 1 as well as various other little changes, Porsche was able to develop the 924 Turbo into the race car they had wanted, dubbing it the 924 Carrera GT.

By this point, however, Stephen's practice of inviting barons to court and arresting them had brought him into some disrepute and increasing distrust.

By that time, players had begun increasing the thickness of the fast sponge layer on their rackets, which made the game excessively fast and difficult to watch on television.

By July 1923, criticism of the Harding Administration had been increasing.

By the Late Republican era, increasing competition among the competitive military-political adventurers who ran Rome's nascent empire ensured that triumphs became more frequent, drawn out and extravagant, prolonged in some cases by several days of public games and entertainments.

By contrast, in T2DM patients daily Mg administration, restoring a more appropriate intracellular Mg concentration, contributes to improve insulin-mediated glucose uptake.

By inhibiting the ability for neurons to perform their expected intracellular functions, or pass a signal to a neighboring cell, neurotoxins can induce systemic nervous system arrest as in the case of botulinum toxin, or even nervous tissue death.

By nature, R. rickettsii is an obligate intracellular parasite that survive by an endosymbiotic relationship with other cells.

By preserving the energy metabolism in cells exposed to hypoxia or ischemia, trimetazidine prevents a decrease in intracellular adenosine triphosphate levels, thereby ensuring the proper functioning of ionic pumps and transmembranous sodium-potassium flow whilst maintaining cellular homeostasis.

By preserving energy metabolism in cells exposed to hypoxia or ischaemia, trimetazidine prevents a decrease in intracellular ATP levels, thereby ensuring the proper functioning of ionic pumps and transmembrane sodium-potassium flow whilst maintaining cellular homeostasis.

By contrast, loop diuretics promote a significant increase calcium excretion.

By purifying urine using salt precipitation, isoelectric focusing, and size-exclusion chromatography, some researchers have found that calgranulin, a protein formed in the kidney, is a potent inhibitor of the in vivo formation of calcium oxalate crystals.

By the 1940s endless uses for calcium products extracted from the marble deposits became obvious.

By 1964, the company had completed one of the largest multi-product calcium carbonate plants in the United States and in 1967 the structural marble plant was closed.

By way of comparison, the body can absorb about half of the calcium present in broccoli, yet only around 5 % of the calcium in spinach.

By the mid-1860s " Horsford's Yeast Powder " was on the market as an already-mixed leavening agent, distinct from separate packages of calcium acid phosphate and sodium bicarbonate.

By partially blocking the potassium channels, the cell remains depolarized, increasing the time the cell spends in the calcium release stage of cell, which results in signaling leading to calcium influx.

By 1800 farms began noticing that horses who grazed in the Bluegrass region were more durable than those from other regions-this is due to the high content of calcium in the soil.

By combining the chemistry of a particular product ( CCE ) and its particle size the Effective Calcium Carbonate Equivalent ( ECCE ) is determined. The ECCE is percentage comparison of a particular agricultural limestone with pure calcium carbonate with all particles smaller than 60 mesh. Typically the aglime materials in commercial use will have ECCE ranging from 45 percent to 110 percent.

By definition, they have at least 35 % base saturation, meaning calcium, magnesium, and potassium are relatively abundant.

By considering the mechanochemical behaviour of the cortical cytoplasm ( or cytogel ) of plant cells, a viscoelastic material mainly composed of actin microfilaments and reinforced by a microtubules network, Goodwin & Trainor ( 1985 ) showed how to couple calcium and the mechanical properties of the cytoplasm.

By 2000, techniques were being used such as cooking vegetables in mineral water after discovering that the levels of calcium in tap water causes their discolouration, and freezing cuttlefish to break down the molecules in them in order to increase their tenderness.

By studying the calcium carbonate in coral rock, past sea surface temperature and hurricane information can be revealed.

By far the most used raw material is mined dolomite, a mixed ( Ca, Mg ) CO < sub > 3 </ sub >, where the calcium oxide present in the reaction zone scavenges the silica formed, releasing heat and consuming one of the products, thus helping push the equilibrium to the right.