A synthetic version, known as pharmahuasca is a combination of an appropriate MAOI and typically DMT.

In this usage, the DMT is generally considered the main psychoactive active ingredient, while the MAOI merely preserves the psychoactivity of orally ingested DMT, which would otherwise be destroyed in the gut before it could be absorbed in the body.

Internationally, DMT is a Schedule I drug under the Convention on Psychotropic Substances.

However, brews made using DMT containing plants are illegal since DMT is a Schedule I drug.

The traditional South American ayahuasca, or yage, is a beverage derived by boiling the Ayahuasca vine ( Banisteriopsis caapi ) with leaves of one or more plants containing DMT, such as Psychotria viridis, Psychotria carthagenensis, or Diplopterys cabrerana.

5-MeO-DMT, a psychedelic drug structurally similar to N, N-DMT, is sometimes referred to as DMT through abbreviation.

As a white, crystalline solid, it is also similar in appearance to DMT.

Psychologically, the DMT experience can be overly-intense, potentially causing overwhelming fear and difficulty integrating experiences if one is not mentally prepared.

Furthermore, due to the intense nature of the experience, DMT is generally considered to have no addiction potential.

This risk is more prevalent with DMT, as DMT is more intense than normal psychedelics.

Several speculative and yet untested hypotheses suggest that endogenous DMT is produced in the human brain and is involved in certain psychological and neurological states.

DMT is naturally occurring in small amounts in rat brain, human cerebrospinal fluid, and other tissues of humans and other mammals.

A new hypothesis proposed is that in addition to being involved in altered states of consciousness, endogenous DMT may be involved in the creation of normal waking states of consciousness.

It is proposed that DMT and other endogenous hallucinogens mediate their neurological abilities by acting as neurotransmitters at a sub class of the trace amine receptors ; a group of receptors found in the CNS where DMT and other hallucinogens have been shown to have activity.

' Basing his reasoning on his belief that all the enzymatic material needed to produce DMT is found in the pineal gland ( see evidence in mammals ), and moreover in substantially greater concentrations than in any other part of the body, Strassman ( p. 69 ) has speculated that DMT is made in the pineal gland.

This inhibition of MAO-A allows DMT to diffuse unmetabolized past the membranes in the stomach and small intestine, and eventually cross the blood – brain barrier ( which, by itself, requires no MAO-A inhibition ) to activate receptor sites in the brain.

Without RIMAs or the MAOI of MAO-A, DMT would be oxidised ( and thus rendered biologically inactive ) by monoamine oxidase enzymes in the digestive tract.

Bogers and Fijneman were charged with distributing a scheduled substance ( DMT ); however, the prosecution was unable to prove that the use of ayahuasca by members of the Santo Daime constituted a sufficient threat to public health and order that it warranted denying their rights to religious freedom under ECHR Article 9.

)</ ref > In a September 2009 interview with Examiner. com, Strassman described the effects on participants in the study: " Subjectively, the most interesting results were that high doses of DMT seemed to allow the consciousness of our volunteers to enter into non-corporeal, free-standing, independent realms of existence inhabited by beings of light who oftentimes were expecting the volunteers, and with whom the volunteers interacted.

The Ayahuasca vine contains harmala alkaloids, highly active reversible inihibitors of monoamine oxidase A ( RIMAs ),< ref name =" BergströmWesterberg1997 "> rendering the DMT orally active by protecting it from deamination.

Induced DMT experiences can include profound time-dilation, visual and auditory illusions, and other experiences that, by most firsthand accounts, defy verbal or visual description.

A biochemical mechanism for this was proposed by the medical researcher J. C. Callaway, who suggested in 1988 that DMT might be connected with visual dream phenomena: brain DMT levels would be periodically elevated to induce visual dreaming and possibly other natural states of mind.

DMT idea by artist L Brown

* DMT: The Spirit Molecule, an overview by its author, Rick Strassman

* Uni-DSL ( Uni Digital Subscriber Line or UDSL ), technology developed by Texas Instruments, backwards compatible with all DMT standards

While running for re-election in 2008, Coleman was mentioned in a Texas lawsuit by Paul McKim, CEO of Deep Marine Technologies ( DMT ) against Nasser Kazeminy.

On Friday, October 31, a related suit was filed in Delaware Chancery Court by minority shareholders in DMT.

Machine elves ( also known as fractal elves, self-transforming machine elves ) is a term coined by the late ethnobotanist, writer and philosopher Terence McKenna to describe the apparent entities ( described as " elves ") that have been reported by some individuals using doses of the psychedelic tryptamine, DMT.

Meyer believes that the objective space that one may enter on DMT, and the faerie world described by Evans-Wentz, are one and the same.

Kent postulates that the DMT landscape is simply disrupting or " editing " our processing of visual information and causing a chaotic interpretation of it inspired by hyperactive phosphene activity.

This circuit is activated by DMT, ketamine, and high doses of LSD ( 1, 000 + µg ).

His model came to be known as the DMT ( after Derjaguin, Muller and Toporov ) model, while the model presented by Western bloc scientists came to be known as the JKR ( after Johnson, Kendall and Roberts ) model for adhesive elastic contact.

* Dimethoxytrityl, ( DMT )-Removed by weak acid.

DMT stopped accepting inbound monetary transfers on October 10, 2004 due to abuse of the system by fraudsters via eBay ' passthough ' scams.

In 2011, Nicholas V. Cozzi, of the University of Wisconsin School of Medicine and Public Health, concluded that INMT, an enzyme that may be associated with the biosynthesis of DMT and endogenous hallucinogens, is present in the human pineal gland, retinal ganglion neurons, spinal cord, and central nervous tissues.

This is because the enzyme monoamine oxidase degrades DMT into an inactive compound before it is absorbed.

In this view, if MAOI is neither present in the plant nor added to the mixture, the enzyme MAO will break apart DMT in the human gut, preventing the active molecule from entering blood and brain.

The recognized mechanism of action is the addition of a monoamine oxidase inhibitor ( MAOI ) present in Banisteriopsis caapi, which allows ayahuasca to be effective in oral doses ( unlike smoking DMT crystals which requires no conditioning partner drug ).

DMT occurs naturally in the human body and is speculated to be released at the time of death, but it is normally digested in the stomach if consumed and an MAOI ( monoamine oxidase inhibitor ), in this case tetrahydroharmine, harmine and harmaline, is needed to allow it to reach the brain in this way, thus the use of the vine.

The petition alleges that Kazeminy used DMT to funnel $ 75, 000 or more to Coleman's wife Laurie through her employer, Hays Companies, in order to enrich Senator Coleman.

The Delaware suit also alleges that DMT was used as a conduit for unearned funds to Laurie Coleman through Hays Companies, at the behest of Kazeminy.

At about minute one or two of a DMT trip, according to McKenna, one may burst through a chrysanthemum-like mandala, and find: