A synthetic version, known as pharmahuasca is a combination of an appropriate MAOI and typically DMT.

In this usage, the DMT is generally considered the main psychoactive active ingredient, while the MAOI merely preserves the psychoactivity of orally ingested DMT, which would otherwise be destroyed in the gut before it could be absorbed in the body.

Internationally, DMT is a Schedule I drug under the Convention on Psychotropic Substances.

However, brews made using DMT containing plants are illegal since DMT is a Schedule I drug.

DMT is broken down by the digestive enzyme monoamine oxidase through a process called deamination, and is therefore inactive if taken orally unless combined with a monoamine oxidase inhibitor ( MAOI ).

The traditional South American ayahuasca, or yage, is a beverage derived by boiling the Ayahuasca vine ( Banisteriopsis caapi ) with leaves of one or more plants containing DMT, such as Psychotria viridis, Psychotria carthagenensis, or Diplopterys cabrerana.

5-MeO-DMT, a psychedelic drug structurally similar to N, N-DMT, is sometimes referred to as DMT through abbreviation.

As a white, crystalline solid, it is also similar in appearance to DMT.

Psychologically, the DMT experience can be overly-intense, potentially causing overwhelming fear and difficulty integrating experiences if one is not mentally prepared.

Furthermore, due to the intense nature of the experience, DMT is generally considered to have no addiction potential.

This risk is more prevalent with DMT, as DMT is more intense than normal psychedelics.

Several speculative and yet untested hypotheses suggest that endogenous DMT is produced in the human brain and is involved in certain psychological and neurological states.

DMT is naturally occurring in small amounts in rat brain, human cerebrospinal fluid, and other tissues of humans and other mammals.

A new hypothesis proposed is that in addition to being involved in altered states of consciousness, endogenous DMT may be involved in the creation of normal waking states of consciousness.

It is proposed that DMT and other endogenous hallucinogens mediate their neurological abilities by acting as neurotransmitters at a sub class of the trace amine receptors ; a group of receptors found in the CNS where DMT and other hallucinogens have been shown to have activity.

' Basing his reasoning on his belief that all the enzymatic material needed to produce DMT is found in the pineal gland ( see evidence in mammals ), and moreover in substantially greater concentrations than in any other part of the body, Strassman ( p. 69 ) has speculated that DMT is made in the pineal gland.

DMT is classified in Canada as a Schedule III drug.

DMT, along with most of its plant sources, is classified in France as a stupéfiant ( narcotic ).

DMT is classified in New Zealand as a Class A drug under the Misuse of Drugs Act 1975.

DMT is classified in the United Kingdom as a Class A drug.

DMT is classified in the United States as a Schedule I drug under the Controlled Substances Act of 1970.

The development of a potentially life-threatening serotonin syndrome ( also more recently classified as " serotonin toxicity ") may occur with venlafaxine treatment, particularly with concomitant use of serotonergic drugs, including but not limited to SSRI and SNRIs, many hallucinogens such as tryptamines and phenethylamines ( LSD / LSA, DMT, MDMA, MDPV, mescaline for example ), dextromethorphan ( DXM )/ dextrorphan ( DXO ), tramadol, tapentadol, meperidine / pethidine and triptans and with drugs that impair metabolism of serotonin ( including MAOIs ).

DMT is classified in the United States as a Schedule I drug.

Neither the crown ( fruit, mescal button ) of the Peyote cactus nor the roots of the plant Mimosa hostilis nor Psilocybe mushrooms themselves are included in Schedule 1, but only their respective principles, mescaline, DMT and psilocin.

Part IV focused on Schedule H " restricted drugs ", those whose only legitimate use is for scientific research, such as the hallucinogens LSD, DMT, and MDA.

The resulting brew contains the powerful psychedelic drug DMT and MAO inhibiting harmala alkaloids, which are necessary to make the DMT orally active.

Blood or plasma DMT levels in recreational users of the drug are generally in the 10 – 30 μg / L range during the first several hours post-ingestion.

The other is Mimosa tenuiflora, which is best known for its use in shamanic ayahuasca brews due to the psychedelic drug DMT found in its root bark.

Bad trip ( or psychedelic crisis ) is a disturbing experience sometimes associated with use of a psychedelic drug such as LSD, Salvinorin A, DXM, mescaline, psilocybin, cannabis, DMT and sometimes even other drugs including alcohol and MDMA.

N-Ethyltryptamine ( NET ), or merely ethyltryptamine, is a psychedelic drug, a tryptamine that is structurally related to N-methyltryptamine ( NMT ) and the psychedelic drugs N, N-dimethyltryptamine ( DMT ) and N, N-diethyltryptamine ( DET ).

The aim was to see whether DMT ( N, N-dimethyltryptamine ), which had then been mostly thought of as a terror-inducing drug, could produce pleasant experiences under a supportive set and setting.

DET, also known under its chemical name N, N-diethyltryptamine and as T-9, is a psychedelic drug closely related to DMT and 4-HO-DET.

The recognized mechanism of action is the addition of a monoamine oxidase inhibitor ( MAOI ) present in Banisteriopsis caapi, which allows ayahuasca to be effective in oral doses ( unlike smoking DMT crystals which requires no conditioning partner drug ).

B. caapi has a tradition of use in conjunction with plants containing the drug DMT.

* The song " Divine Moments of Truth " is a tribute to the psychoactive drug Dimethyltryptamine ( DMT ).

Bogers and Fijneman were charged with distributing a scheduled substance ( DMT ); however, the prosecution was unable to prove that the use of ayahuasca by members of the Santo Daime constituted a sufficient threat to public health and order that it warranted denying their rights to religious freedom under ECHR Article 9.

Natural materials containing DMT, including ayahuasca, are explicitly not regulated under the 1971 Psychotropic Convention.

It has also been reported under the influence of tryptamine psychedelics including dimethyltryptamine ( DMT ) from ayahuasca.

In an article published in The Journal of Mental Science ( now the British Journal of Psychiatry ) in 1958 under the title “ Dimethyltryptamine Experiments with Psychotics ”, researcher Stephen Szara ( the chemist who first studied the human effects of DMT ) talked about how one of his subjects under the influence of DMT had experienced “ strange creatures, dwarves or something ” at the beginning of the trip.

Strassman refers to DMT as the " god molecule " or " spirit molecule " due to many users claiming of contacting non-human or god-like beings under the alkaloid's influence.

Of the 60 human volunteers who've ingested DMT under Strassman's watch, more than half reported similar experiences.

Others in the field of neurochemistry have not accepted this explanation of DMT's role in this function due to the absence of supporting evidence ( i. e. a plausible synthesis mechanism or direct evidence that DMT is found in higher concentration in the body under these circumstances ).