During the Han dynasty, Zhang Zhongjing, who was mayor of Changsha near the end of the 2nd century AD, wrote a Treatise on Cold Damage, which contains the earliest known reference to the Neijing Suwen.

The earliest original writings in Coptic language were the letters by St. Anthony of Egypt, first of the “ Desert Fathers .” During the 3rd and 4th centuries many ecclesiastics and monks wrote in Coptic, among them, St. Pachomius, whose monastic rule ( the first cenobitic rule, for solitary monks gathered in communities ) survives only in Coptic.

During 1893 the juvenile quality of his earliest work falls away, and by 1894 his career as a painter can be said to have begun.

During the earliest parts of psychoanalytic history, analysts granted that homosexuality was non-pathological in certain cases, and the ethical question of whether it ought to be changed was discussed.

The earliest spring-driven timepiece with a second hand which marked seconds is an unsigned clock depicting Orpheus in the Fremersdorf collection, dated between 1560 and During the 3rd quarter of the 16th century, Taqi al-Din built a clock with marks every 1 / 5 minute.

During the 1230s, a city wall was built, enclosing 38 hectares, when the earliest stone houses on the Rennweg were built as well.

During the Archaic ( please see Archaic Greece ) and early Classical periods ( about the 6th and early 5th centuries BCE ), the architectural forms of the earliest temples had solidified and the Doric ( see Classical order ) emerged as the predominant element.

During the island's earliest history it became the domain of Jean Lafitte, the famed pirate and American hero of the War of 1812.

During the Register's earliest years in the late 1960s and early 1970s, organization was lax and SHPOs were small, understaffed, and underfunded.

" During shooting, Bogart was already suffering from the earliest symptoms of the throat cancer that would eventually kill him.

During the earliest years of the reign of Menes, according to Manetho, the seat of power was further to the south, at Thinis.

During its earliest years, the station was affiliated with NBC, ABC, DuMont, and the CMQ Television Network.

During its earliest years, the location was usually spelled as " Cranberry ".

During the British colonial period, the earliest settlers of European descent arrived in this portion of the colony of New Jersey.

During this time, seeds began to be offered for sale in Europe, the earliest known dating from 1813, with John Fraser offering four species in London, followed by Flanagan & Nutting offering nine species in their 1835 catalog.

During this time, Bradfield had tried writing lyrics, but this later changed and Wire wrote all their earliest lyrics, leaving Bradfield, alongside the classically-trained Sean Moore when he joined, to write the music.

During this era the earliest global-scale continent-continent collisional belts developed.

During the earliest Paleozoic Era, the continent that would later become North America straddled the equator.

During a visit to Sicily in 1816, Meyerbeer noted down a number of folksongs, and these in fact constitute the earliest collection of folk music of the region.

During this time, papers on the Apollo program missions and some of the earliest reports on AIDS were published.

During the earliest era of air combat in World War I, a small number of frontline German fighter pilots serving with what would become known as the Luftstreitkräfte wore hard bridge pince-nez frames for their corrective lenses, including the very first pilot to defeat an opposing aircraft ( on July 1, 1915 ) using a synchronized machine-gun armed aircraft, Leutnant Kurt Wintgens.

During this time, St. Paul's College and St. Joseph's College competed in the earliest inter-school football matches ever played in the colony.

During its earliest stages, it is sometimes known as Bowen's disease.

During this time, and in spite of the attacks, the city of Vigo developed its earliest commerce, and was given several privileges by the kings of Spain.

During its flowering in the sixth to the eighth centuries, Mahayana offered a supernatural package to the Chinese which bears no resemblance to the highly digested philosophical Zen morsels offered to the modern Western reader.

During the Sino-Japanese War ( 1937 – 1945 ) and World War II ( 1939 – 1945 ), the Special Research Units of the Imperial Japanese Army, such as Unit 731, conducted human experimentation on thousands of Chinese, among others.

During the 1992 Barcelona and 1996 Atlanta Opening Ceremonies, Costas ' remarks on China's teams ' possible drug use caused an uproar among the American Chinese and international communities.

During the 19th and 20th centuries, Chinese philosophy integrated concepts from Western philosophy.

During this era, Chinese scholars attempted to incorporate Western philosophical ideologies such as democracy, Marxism, socialism, liberalism, republicanism, and nationalism into Chinese philosophy.

During this period, archaeological evidence points to an increase in literacy and a partial shift away from the faith placed in Shangdi ( the Supreme Being in traditional Chinese religion ), with ancestor worship becoming commonplace and a more worldly orientation coming to the fore.

During the Industrial and Modern Ages, Chinese philosophy had also begun to integrate concepts of Western philosophy, as steps toward modernization.

During the early computer era, Chinese characters were categorized by their radicals or Pinyin ( or romanization ), but results weren't completely satisfactory.

During this so-called Republican Era, many features of a modern, functional Chinese state emerged and developed.

During the Tang Dynasty ( 618-907 ), the Chinese used a silver canister where written lots could be drawn that designated which player had to drink and specifically how much ; for example, from 1, 5, 7, or 10 measures of drink that the youngest player, or the last player to join the game, or the most talkative player, or the host, or the player with the greatest alcohol tolerance, etc.

During his trip, a tempest forced him to stop on an island near Guangzhou, China where he saw the rich merchant Diogo Pereira, an old friend from Cochin, who showed him a letter from Portuguese being held prisoners in Guangzhou asking for a Portuguese ambassador to talk to the Chinese Emperor in their favor.

During the Chinese Song Dynasty ( 960-1279 AD ), not only landscape art was improved upon, but portrait painting became more standardized and sophisticated than before ( for example, refer to Emperor Huizong of Song ), and reached its classical age maturity during the Ming Dynasty ( 1368-1644 AD ).

During the late 13th century and first half of the 14th century, Chinese under the Mongol-controlled Yuan Dynasty were not allowed to enter higher posts of government ( reserved for Mongols or other ethnic groups from Central Asia ), and the Imperial examination was ceased for the time being.

During the Qianlong reign period and the continuing 19th century, European Baroque styles of painting had noticeable influence on Chinese portrait paintings, especially with painted visual effects of lighting and shading.

During his stay at Hangzhou he was particularly impressed by the large number of well-crafted and well-painted Chinese wooden ships, with colored sails and silk awnings, assembling in the canals.

During the Korean War, Soviet pilots flew Soviet aircraft from Chinese bases against United Nations aircraft defending South Korea.

During the Warring States period of Chinese history ( 480-221 BC ) extensive development in martial philosophy and strategy emerged, as described by Sun Tzu in The Art of War ( c. 350 BC ).

During the Korean War, Hunter, who worked at the time both as a journalist and as a U. S. intelligence agent, wrote a series of books and articles on the theme of Chinese brainwashing.

During the late Eastern Han, disastrous upheavals again occurred in the process of social transformation, leading to the greatest social disorder in Chinese history.

During this period, the portrayal of opium in literature became squalid and violent, British opium trade was largely supplanted by domestic Chinese production, purified morphine and heroin became widely available for injection, and patent medicines containing opiates reached a peak of popularity.

During a 2008 interview with the BBC, Major General Qian Lihua, a senior Chinese defense official, stated that the PLAN aspired to possess a small number of aircraft carriers to allow it to expand China's air defense perimeter.

During the Ming Dynasty ( AD 1368 – 1644 ), the Chinese were very concerned with city planning in regards to gunpowder warfare.

During World War II, Madame Chiang tried to promote the Chinese cause and build a legacy for her husband on par with Roosevelt, Churchill and Stalin.

During the same time, Chan Buddhism grew to become the largest sect in Chinese Buddhism.