Early clinical trials typically enroll a very small number of patients, and the purpose is to identify major safety issues and the maximum tolerated dose, which is the highest dose that does not produce serious or fatal adverse effects.

Early in the novel, Jack Ryan, the new President, issues a presidential pardon to John Terence Kelly for his several murders.

Early national attention to trick-or-treating was given in October 1947 issues of the children's magazines Jack and Jill and Children's Activities, and by Halloween episodes of the network radio programs The Baby Snooks Show in 1946 and The Jack Benny Show and The Adventures of Ozzie and Harriet in 1948.

Early X-Men issues introduced the team's archenemy Magneto and his Brotherhood of Evil Mutants featuring Mastermind, Quicksilver, Scarlet Witch, and Toad.

Early issues featured two SF-themed stories aimed at a slightly older age group than 2000 AD and soon became a magnet for British creators who wanted to create comics for the adult market.

Early in his tenure, he differed from his party on several issues ; his was the solitary Republican vote to terminate the use of bounties in recruiting.

Early optical character recognition could be traced to activity around two issues: expanding telegraphy and creating reading devices for the blind.

When Nikki Wood's son Robin tries to kill Spike, he unwittingly frees Spike from his hypnotic trigger: the song " Early One Morning ", a favorite of his mother, which evokes Spike's traumatic memories of his mother's abusive behavior toward him after she turned ; after Spike is able to address these issues, he realizes his mother had always loved him, knowledge which frees him from the First's control.

Early in 1961 the President appointed General Maxwell Taylor to serve as his military representative and provide liaison with the government agencies and defense and intelligence establishments on military-political issues confronting the administration.

Early in their career, their 1993 EP Jenny Ondioline entered the UK Singles Chart, but financial issues prevented the band from printing enough records to satisfy demand.

" Early issues of the Knoxville Gazette — the first newspaper published in Tennessee — are filled with accounts of murder, theft, and hostile Cherokee attacks.

Early on, the organization focused on government surveillance and cryptography issues, such as the Clipper Chip and the Communications Assistance for Law Enforcement Act, or CALEA.

The majority of the YWCA USA associations publicly advocate on Racial Justice, Violence Against Women, Early Childhood Education and Increasing Women's Income issues.

Early issues of Eightball featured a mixture of very short, often crudely humorous comics (" Zubrick and Pogeybait ", " The Sensual Santa "), topical rants and satires (" Art School Confidential ", " On Sports "), longer, more reflective self-contained stories (" Caricature ", " Immortal Invisible "), and serialized works.

Early MMS deployments were plagued by technical issues and frequent consumer disappointments, such as having sent an MMS message, receiving a confirmation it had been sent, being billed for the MMS message, to find that it had not been delivered to the intended recipient.

A unique version of April appeared in the final issues of Star Trek: Early Voyages where he appeared as a stubborn and extremely militaristic person, who ordered an attack against an unknown ship that was making provocative moves against the Enterprise, despite the fact that Number One was in command.

Early in the strip's run, FoxTrot often dealt with societal issues such as drug abuse.

Early issues of The Amazing Spider-Man featured a running joke about Peter dodging his Aunt May's attempts to set him up with " that nice Watson girl next door ", whom Peter had not yet met and assumed would not be his type, since his aunt liked her ( in the Parallel Lives graphic novel an identical scenario is shown between Mary Jane and her Aunt Anna ).

Unlike some of his predecessors who filled the role, Early routinely prepared Roosevelt for his press conferences, bringing the President's attention to issues that might come up, suggesting the appropriate answers, and even planting questions or issues with certain reporters.

" Early issues included articles by such writers as Hardwick, Lowell, Jason Epstein, Hannah Arendt, W. H. Auden, Saul Bellow, John Berryman, Truman Capote, Paul Goodman, Lillian Hellman, Irving Howe, Alfred Kazin, Dwight Macdonald, Norman Mailer, Mary McCarthy, Norman Podhoretz, Philip Rahv, Susan Sontag, William Styron, Gore Vidal, Robert Penn Warren and Edmund Wilson.

Early work on transformations used paraphrase as a heuristic, but Harris recognized that this was inadequate ( e. g. in Harris 1954 ) and, in keeping with the methodological principles noted above in the section on metalanguage issues and earlier, sought a formal criterion for transformational analysis.

Early drive-in theaters had to deal with noise pollution issues.

The program was simply known as the " Early Show " and primarily consisted of lively ( and sometimes confrontational ) discussion of contemporary issues in American politics, culture, and current events.

He also wrote songs, including his Seven Early Songs ( Sieben Frühe Lieder ), three of which were Berg's first publicly performed work in a concert that featured the music of Schoenberg's pupils in Vienna that year.

Early minivans featured one rear side sliding door on the passenger's side, similar to full-sized passenger vans in the early 1980s.

Early models featured a pioneering form of variable valve timing in an attempt to give greater control, but this caused the valves to burn and therefore it was abandoned.

Early editions featured symbolic views of Oxford, but in 1766 these gave way to realistic studies of the city or university.

Early concepts for the Mars balloon featured a " dual balloon " system, with a sealed hydrogen or helium-filled balloon tethered to a solar Montgolfiere.

Early shows relied on a Satanic image, which featured pentagrams, make-up, spikes, and inverted crosses.

Early rehearsals took place in Cocker's house and featured Cocker, Dalton and Dalton's younger brother Ian.

Early 1930s cartoons featured popular musicians performing their hit songs on-camera in live-action segments during the cartoons.

Early industrial music often featured tape editing, stark percussion and loops distorted to the point where they had degraded to harsh noise, such as the work of early industrial group Cabaret Voltaire, which Journalist Simon Reynolds described as characterized by " hissing high hats and squelchy snares of rhythm-generator.

Following the runaway success of The Beautiful Letdown, a compilation titled The Early Years: 1997-2000 was released, which featured Switchfoot's first three indie albums released under Re: think records including the original artwork for all the albums.

* The Parliaments-Testify: The Best Of The Early Years-Connoisseur VSOP CD 286-contains all of the tracks featured on " Testify " and also includes " She's Always There ", which is the flip side to the Fellows single " Let's Make It Last ".

His artwork was featured on CBS's The Early Show where his " 44 Obamas ," commemorating the 44th President of The United States, was debuted.

Early examples simply featured hammocks and a stove in the hold of a trader, but boatbuilders soon began to make craft specifically for pleasure sailing and holidays, using the same hull and rig design but incorporating living quarters instead of a cargo hold.

Early comic fanzines from around 1970 featured Franquin's Monsters, individual drawings of imaginary beasts highlighting his graphical craftmanship.

Early magazine advertisements ( featured in graphic design trade magazines such as Communication Arts ) referred to the product as " the Adobe Illustrator ".

Early versions featured simplified graphics, and the different ports were met with mixed reception.

In September 2009, he featured on a radio podcast by Aleksandr Orlov of Compare the Meerkat, part of the advertising for British website, Comparethemarket. com He was also the subject of an Early Day Motion in the House of Commons of the United Kingdom as a result of his support for the re-opening of Morecambe Winter Gardens.

The earliest stone churches in Russia featured Byzantine style domes, however by the Early Modern era the onion dome had become the predominant form in traditional Russian architecture.

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Early games often featured a level system of ascending difficulty as opposed to progression of story-line.

Early model T-72s did not feature side skirts ; instead the original base model featured gill or flipper-type armour panels on either side of the forward part of the hull.

Early units had one pickup for mono output, later models featured two pickups for stereo use.

Early albums, such as Hell Awaits and Reign in Blood, featured a " wailing style " and " demented soloing often mimicking the screams of the song's victims.