Early clinical trials typically enroll a very small number of patients, and the purpose is to identify major safety issues and the maximum tolerated dose, which is the highest dose that does not produce serious or fatal adverse effects.

Early in the novel, Jack Ryan, the new President, issues a presidential pardon to John Terence Kelly for his several murders.

Early national attention to trick-or-treating was given in October 1947 issues of the children's magazines Jack and Jill and Children's Activities, and by Halloween episodes of the network radio programs The Baby Snooks Show in 1946 and The Jack Benny Show and The Adventures of Ozzie and Harriet in 1948.

Early X-Men issues introduced the team's archenemy Magneto and his Brotherhood of Evil Mutants featuring Mastermind, Quicksilver, Scarlet Witch, and Toad.

Early issues featured two SF-themed stories aimed at a slightly older age group than 2000 AD and soon became a magnet for British creators who wanted to create comics for the adult market.

Early in his tenure, he differed from his party on several issues ; his was the solitary Republican vote to terminate the use of bounties in recruiting.

Early optical character recognition could be traced to activity around two issues: expanding telegraphy and creating reading devices for the blind.

When Nikki Wood's son Robin tries to kill Spike, he unwittingly frees Spike from his hypnotic trigger: the song " Early One Morning ", a favorite of his mother, which evokes Spike's traumatic memories of his mother's abusive behavior toward him after she turned ; after Spike is able to address these issues, he realizes his mother had always loved him, knowledge which frees him from the First's control.

Early in 1961 the President appointed General Maxwell Taylor to serve as his military representative and provide liaison with the government agencies and defense and intelligence establishments on military-political issues confronting the administration.

Early issues featured a range of broadly anarchist and ecological ideas, bringing together groups and individuals as varied as Class War, veteran anarchist writer Colin Ward, anarcho-punk band Crass, as well as the Peace Convoy, anti-nuclear campaigners, animal rights activists and so on.

Early in their career, their 1993 EP Jenny Ondioline entered the UK Singles Chart, but financial issues prevented the band from printing enough records to satisfy demand.

Early on, the organization focused on government surveillance and cryptography issues, such as the Clipper Chip and the Communications Assistance for Law Enforcement Act, or CALEA.

The majority of the YWCA USA associations publicly advocate on Racial Justice, Violence Against Women, Early Childhood Education and Increasing Women's Income issues.

Early issues of Eightball featured a mixture of very short, often crudely humorous comics (" Zubrick and Pogeybait ", " The Sensual Santa "), topical rants and satires (" Art School Confidential ", " On Sports "), longer, more reflective self-contained stories (" Caricature ", " Immortal Invisible "), and serialized works.

Early MMS deployments were plagued by technical issues and frequent consumer disappointments, such as having sent an MMS message, receiving a confirmation it had been sent, being billed for the MMS message, to find that it had not been delivered to the intended recipient.

A unique version of April appeared in the final issues of Star Trek: Early Voyages where he appeared as a stubborn and extremely militaristic person, who ordered an attack against an unknown ship that was making provocative moves against the Enterprise, despite the fact that Number One was in command.

Early in the strip's run, FoxTrot often dealt with societal issues such as drug abuse.

Early issues of The Amazing Spider-Man featured a running joke about Peter dodging his Aunt May's attempts to set him up with " that nice Watson girl next door ", whom Peter had not yet met and assumed would not be his type, since his aunt liked her ( in the Parallel Lives graphic novel an identical scenario is shown between Mary Jane and her Aunt Anna ).

Unlike some of his predecessors who filled the role, Early routinely prepared Roosevelt for his press conferences, bringing the President's attention to issues that might come up, suggesting the appropriate answers, and even planting questions or issues with certain reporters.

" Early issues included articles by such writers as Hardwick, Lowell, Jason Epstein, Hannah Arendt, W. H. Auden, Saul Bellow, John Berryman, Truman Capote, Paul Goodman, Lillian Hellman, Irving Howe, Alfred Kazin, Dwight Macdonald, Norman Mailer, Mary McCarthy, Norman Podhoretz, Philip Rahv, Susan Sontag, William Styron, Gore Vidal, Robert Penn Warren and Edmund Wilson.

Early work on transformations used paraphrase as a heuristic, but Harris recognized that this was inadequate ( e. g. in Harris 1954 ) and, in keeping with the methodological principles noted above in the section on metalanguage issues and earlier, sought a formal criterion for transformational analysis.

Early drive-in theaters had to deal with noise pollution issues.

The program was simply known as the " Early Show " and primarily consisted of lively ( and sometimes confrontational ) discussion of contemporary issues in American politics, culture, and current events.

Early Knoxville has been described as an " alternately quiet and rowdy river town.

Early in its history the Gazette scrupulously avoided political involvement or endorsement.

Ned Chilton's widow, Elizabeth Early " Betty " Chilton, is now president of the Daily Gazette Co. and publisher of The Charleston Gazette.

Early in 1845 critical reviews appeared in the Athenaeum, the Literary Gazette and The Gardeners ' Chronicle.

* Women Priests, Vegetarianism-An Early Christian Manuscript Holds Some Surprises -- from the Harvard University Gazette.

She was thus a principal agent — almost an embodiment — of the work of the Catholic Church during the Early Middle Ages in the construction of the religion-culture of western Europe.

Early releases of AutoCAD used primitive entities — lines, polylines, circles, arcs, and text — to construct more complex objects.

Early clavichords frequently had many notes played on each string, even going so far as the keyed monochord — an instrument with only one string — though most clavichords were triple-or double-fretted.

Early sources: river Ilfing ( 890 ), Castrum de Elbingo quod a nomine fluminis Elbingum appellavit ( 1237 — Peter of Dusburg, Chronicon terrae Prussiae ), in Elbingo ( 1239 ), in Elbing ( 1242 ), in Elbinge ... fluvium Elbinc ( 1246, city charter ), de Elbingo ( 1250 ), in Elbyngo ( 1258 ), vitra Elbingum ( 1263 ), Elvingo ( 1293 ), in Elbingo ( 1300 ), in Elvingo ( 1389 ), czum Elbinge ( 1392 ), czu Elbing ( 1403 ), Elwing ( 1410 ), czum Elwinge ( 1412 ), Elbing ( 1414 – 1438 ), Elbyang ( before 1454 ), Elbing ( 1508 ), ku Elbiągowi ( 1634 ), w Elblągu ( 1661 ), w Elblągu ( 1661 ).

Early models contained ten rounds and were fitted to modified versions of the Jarmann — though they could be adapted to any bolt action rifle.

Early in the year, the Welsh forces suffered a series of defeats — which was a bad sign as to date, the rebellion had seen many easy defeats of the English forces.

Early stamp images were almost always produced from engravings — a design etched into a steel die, which was then hardened and whose impression was transferred to a printing plate.

Radiocarbon dating puts the oldest surviving archaeological artifacts from Slovakia — found near Nové Mesto nad Váhom — at 270, 000 BCE, in the Early Paleolithic era.

Early signs of a peace dividend were visible throughout the economy — Sri Lanka has been able to reduce defense expenditures and begin to focus on getting its large, public sector debt under control.

Historically, Samaritans were a large community — up to more than a million in late Roman times, but were then gradually reduced to several tens of thousands a few centuries ago — their unprecedented demographic shrinkage has been a result of various historical events, including, most notably, the bloody suppression of the Third Samaritan Revolt ( 529 CE ) against the Byzantine Christian rulers, and mass conversion to Islam in the Early Muslim period of Palestine.

Early on, Smear was the only musically experienced member — Doom survived early performances by sliding a finger up and down the fretboard of her bass while Rhia generally kept a minimal beat on the bass drum, periodically bashing a cymbal.

Dendrochronology has become important to art historians in the dating of panel paintings, and can also provide information as to the source of the panel — many Early Netherlandish paintings have turned out to be painted on panels of " Baltic oak " shipped from the Vistula region via ports of the Hanseatic League.

Early emigrants came primarily from the coastal provinces of Guangdong and Fujian ( Fukien, Hokkien ) – where Cantonese, Hakka, and Chaozhou ( Teochew, Chiu Chow ) and Hokkien are largely spoken — in southeastern China.

With the inclusion of the predecessor and successor cultures — Early Harappan and Late Harappan, respectively — the entire Indus Valley Civilization may be taken to have lasted from the 33rd to the 14th centuries BCE.

Early on, Rouse said that he hoped Tivoli would be a place “ where, under the benign influence of having fun and relaxing in familiar ways, people would have opportunities, especially attractively and conveniently presented, for discovering new ways to enjoy their free time — new foods, new visual and tactile aesthetic experiences, even new social relations .” Rouse wanted the town center in Columbia to provide the most comprehensive range of recreational activities and services that had ever been contemplated in a new town.

Chancery Standard was not the only influence on later forms of English — its level of influence is disputed and a variety of spoken dialects continued to exist — but it provided a core around which Early Modern English could crystallise.

Early in 1797, the Spanish fleet of 27 ships of the line, which were supposed to join the French fleet at Brest lay at Cartagena, on the Mediterranean Sea, with the intention of sailing to Cádiz as an escort of a 57 merchant convoy, carrying mainly mercury — necessary for gold and silver production — which would eventually enter that Spanish harbour along with warships Neptuno, Terrible and Bahama, prior to running into the British force.