However, the potential for clozapine to cause toxic side effects, including agranulocytosis, limits its usefulness.

However, technologists such as Bill Joy have warned of the potential power which genetic engineering might place in the hands of future bio-terrorists.

However, they are much less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken ; however, when combined with other central nervous system depressants such as alcohol and opiates, the potential for toxicity and fatal overdose increases.

However, the Ionian Revolt had directly threatened the integrity of the Persian empire, and the states of mainland Greece remained a potential menace to its future stability.

However, Pedro de Valdivia, captain of the army, realizing the potential for expanding the Spanish empire southward, asked Pizarro's permission to invade and conquer the southern lands.

However, he allowed both Plectrude and the young Theudoald to live and treated them with kindness — unusual for those times, when mercy to a former gaoler, or a potential rival, was rare.

However, the rebellion of Tacfarinas had shown how exposed Africa Proconsularis was to its west and how the Mauretanian client kings were unable to provide protection to the province, and it is thus possible that Caligula's expansion was a prudent response to potential future threats.

However, Khrushchev and Malenkov were able to gather enough support for Beria's ouster, but only when a rumour of a potential coup led by Beria began to take hold within the party leadership.

However, a mulatto who escaped the destruction of Syn's previous ship stowed away in Clegg's ship and accused him before the crew ; Clegg quelled the potential mutiny by having the mulatto's tongue cut out, marooning him on a coral reef and violently killing Yellow Pete, the ship's Chinese cook, who represented the crew in their wish to rescue the mulatto.

However, these potential bite marks were first noticed in photographs years after the trials and were not inspected by a board-certified medical examiner until four years after the murders.

However, the reactions are reversible and the role of a particular electrode in a cell depends on the relative oxidation / reduction potential of both electrodes.

In order for this reaction to occur the power supply should provide at least a potential of 4 V. However, larger voltages must be used for this reaction to occur at a high rate.

However, it was to take another three years, and a change of coach, before the team's obvious potential was translated into tangible success.

However, this is a specific property of hydrogen and is no longer true for more complicated atoms which have a ( effective ) potential differing from the form 1 / r ( due to the presence of the inner electrons shielding the nucleus potential ).

However, some states are the subject of potential irredentism from their inception.

However, in order to not limit potential detainee's freedoms too much it is characterized by the time limit of near future.

However, more recently researchers have brought attention to potential underlying causes of OCBs, including social pressure, coercion, and other external forces.

However, according to Painter unlike the Testimonium this issue has not generated a great deal of controversy, although viewed as a potential reason for doubting authenticity.

However, other scientists have written that " the full potential PCR was not realized " until Mullis ' work in 1983, and that Mullis ' colleagues failed to see the potential of the technique when he presented it to them.

However, it soon became apparent that the Slipstream project had the potential to be much more than a peripheral.

However, there is also significant potential for extremes of hot and cold swings in temperature all year long.

However shielded twisted pair was used in IBM's Token Ring implementation, and in 1984 StarLAN showed the potential of simple unshielded twisted pair by using Cat3 — the same simple cable used for telephone systems.

However in 2010, only 330, 000 passengers of a potential 11 million Tube passengers claimed compensation for delays.

However the assumptions used in the appraisal ( especially the equity discount rate and the projection of the cash flows to be achieved ) are likely to be at least as important as the precise model used.

However, in many companies, management has reached the conclusion that optimizing the product flows cannot be accomplished without implementing a process approach to the business.

However the river flows through much of Shepton Mallet itself in underground culverts.

However, the Petaluma River which flows into San Pablo Bay, is navigable up to the city of Petaluma.

However, the Milwaukee River flows just east of the village.

However, the feature with which he is forever associated is the lake, a huge stretch of water created by damming the River Glyme and ornamented by a series of cascades where the river flows in and out.

However, by October 2008 it was evident that the return of environmental flows to the Snowy River in 2009 would be no more than 4 % of natural flow with governments arguing the Snowy River needs to " pay back " the " Mowamba Borrowings ".

However, this gives poor gas flows within the cylinder head as well as heat problems and fell out of favor for automobile use, see flathead engine.

However, thermocapillary flows on Earth are very difficult to study because they are often masked by much stronger buoyancy-driven flows.

However, the analysis of compressible flows in the transonic regime has led to some developments which help reduce the increases in drag caused by compressibility effects, including the use of swept wings and the Whitcomb area rule.

However, the hazard of using butterfly needles lies in the fact that as the blood flows through the rubber tubing, it cools significantly, thereby clotting faster.

However, there are several spots where the river narrows to less than half a kilometre ( 0. 3 mi ) and flows quickly, such as at the Sans Sault Rapids at the confluence of the Mountain River and " The Ramparts ", a deep canyon south of Fort Good Hope.

However, Piedra Volada flows only during the rainy season, while Basaseachic flows year-round.

However, as mentioned, there are periods of time in which cash flow can be negative ( more cash flows out than in ).

However, when metal flows over a sharp corner in the die, like the edges of a mintmark or words, it tends to roll the detail out.

However, as it flows through the lymph nodes it comes in contact with blood, and tends to accumulate more cells ( particularly, lymphocytes ) and proteins.

" However it should be noted that such normative comments notwithstanding, these types of flows and any destructive results are rooted in and properly attributed to the extra market activities of central bank market manipulations that in fact cause such persistent conditions of disequilibrium and insulates them against free market forces that otherwise would quickly eliminate the incentive for such flows.

However, instead of WACC, cash flows would be discounted at the unlevered cost of equity, and tax shields at either the cost of debt ( Myers ) or following later academics also with the unlevered cost of equity.

However, Perutz found a problem: ice slowly flows, in what is known as plastic flow, and his tests showed that a Pykrete ship would slowly sag unless it was cooled to.

However, the brook Gladbeck flows under the ground nowadays.