However, when there's a job to be done, I'm a monstrosity of grim determination, I like to think.

However, when he assumed the duties of a conductor, he relinquished his career as a pianist.

However, as a practicing historian, he, himself, has left few clues to the amount of professional scholarship that he used when writing history.

However, any such suggestion accounts for only some of the difficulties in hearing tone, or in developing a realistic attitude about tone, but not for the analytic difficulties that occur even when tone is meticulously recorded.

However, when labor disputes arise, its provisions come clearly into play.

However, when philosophy attempts to stand above the sciences, to dictate the conditions of empirical research, it becomes formal metaphysics ; ;

However, when volunteers generously placed the interests of others before their own by making charitable donations, another brain circuit was selectively activated: the subgenual cortex / septal region.

However, he had a strong interest in the fledgling motion picture industry and when Essanay Studios offered him the opportunity to become a scriptwriter, he took the job.

However, it would require all data transmission to send eight bits when seven could suffice.

However, the Greeks thought of the two qualities as complementary: the two gods are brothers, and when Apollo at winter left for Hyperborea, he would leave the Delphic oracle to Dionysus.

However, when applied to data from non-randomized experiments or observational studies, model-based analysis lacks the warrant of randomization.

However, when anxiety becomes overwhelming, it may fall under the classification of an anxiety disorder.

However, when forced to choose between Poirot and his wife in that novel, he initially chooses to betray Poirot to the Big Four so that they would not torture and kill his wife.

However, in general, the books only feature mental battles when there is some reason for mind-to-mind contact ( for example, Trump contact ) and magic or Trump is involved in all three of the above conflicts, so it is not clear whether Zelazny intended his characters to have such a power ; the combination of Brand's " living trump " powers and his high Psyche ( as presented in the roleplaying game ) would have guaranteed him victory over Corwin.

However, its intermediate result storage mechanism, a paper card writer / reader, was unreliable, and when inventor John Vincent Atanasoff left Iowa State College for World War II assignments, work on the machine was discontinued.

However, he continued his slave trading career until 1754 or 1755, when he ended his seafaring altogether and began studying Christian theology.

However, the Prosopography of the Later Roman Empire interprets events and sources differently, believing that Alboin married Chlothsind when already a king in or shortly before 561, the year of Chlothar's death.

However, when campaigning against Germanic tribes of Germania, Alexander attempted to bring peace by engaging in diplomacy and bribery.

However, when the time came, Anna quickly and surreptitiously mobilized the remainder of the family and took refuge in the Hagia Sophia.

However, this situation changed drastically when Alexios ' first son John II Komnenos was born in 1087: Anna's engagement to Constantine was dissolved, and she was moved to the main Palace to live with her mother and grandmother.

However, when an Athenian took up an office, he was regarded as ' serving ' the people.

However, the allophone phenomenon becomes obvious when speakers switch languages.

However, when there are complementary allophones of a phoneme, so that the allophony is significant, things become more complicated.

However, in some situations, especially when deep behind enemy lines, the actual attack will be carried out by a platoon, a company-sized unit will be deployed to support the attack group, setting up and maintaining a forward patrol harbour from which the attacking force will deploy, and to which they will retire after the attack.

However, in 2004, Maher concluded that " Physical treatments, such as acupuncture, backschool, hydrotherapy, lumbar supports, magnets, TENS, traction, ultrasound, Pilates therapy, Feldenkrais therapy, Alexander technique, and craniosacral therapy are either of unknown value or ineffective and so should not be considered " when treating lower back pain with an evidence-based approach.

However, for optimal ligation efficiency with cohesive-ended fragments (" sticky ends "), the optimal enzyme temperature needs to be balanced with the melting temperature T < sub > m </ sub > ( also the annealing temperature ) of the sticky ends being ligated.

However, in 1926, James B. Sumner showed that the enzyme urease was a pure protein and crystallized it ; Sumner did likewise for the enzyme catalase in 1937.

However, the Joint Commission on Biochemical Nomenclature ( JCBN ) dictates that ' synthase ' can be used with any enzyme that catalyses synthesis ( whether or not it uses nucleoside triphosphates ), whereas ' synthetase ' is to be used synonymously.

However, Drexler addresses this in Nanosystems by showing mathematically that well designed catalysts can provide the effects of a solvent and can fundamentally be made even more efficient than a solvent / enzyme reaction could ever be.

However, the enzyme involved in the phosphorlyation is unknown in vivo.

However the last enzyme is absent in humans, explaining the disease known as gout, caused by the accumulation of uric acid.

However, the enzyme discovered by Ochoa ( polynucleotide phosphorylase ) was later shown to be responsible for RNA degradation, not RNA synthesis.

However, in 1970 when the scientists Howard Temin and David Baltimore both independently discovered the enzyme responsible for reverse transcription, named reverse transcriptase, the possibility that genetic information could be passed on in this manner was finally accepted.

Scurvy does not occur in most animals because they can synthesize their own vitamin C. However, humans and other higher primates ( the simians and tarsiers ), guinea pigs, most or all bats, and some species of birds and fish lack an enzyme ( L-gulonolactone oxidase ) necessary for such synthesis and must obtain vitamin C through their diet.

However, the main theoretical reason is that whereas the other polymers listed here are primarily generated in a ' template-dependent ' manner by one processive enzyme, each individual join in a polysaccharide may be formed by a different enzyme.

However, C. botulinum tolerates traces of oxygen due to the enzyme superoxide dismutase ( SOD ) which is an important antioxidant defense in nearly all cells exposed to oxygen.

However Imatinib, as an inhibitor to the malfunctioning enzyme, can be effective.

However, in previous studies the HEXA enzyme itself has been thought to be too large to pass through the specialized cell layer in the blood vessels that forms the blood – brain barrier in humans.

However, many of the neurobehavioral symptoms postulated to be due to toxoplasmosis correlate to the general function of dopamine in the human brain, and the fact that toxoplasma encodes the dopamine-synthesizing enzyme tyrosine hydroxylase makes it likely the neurobehavioral symptoms can result from infection.

However, the signal has to be associated with the presence of antibody or antigen, which is why the enzyme has to be linked to an appropriate antibody.

However, the sodium does not necessarily act as a regulatory subunit ; the sodium is always present and there are no known biological processes to add / remove sodium to regulate enzyme activity.

However, editing by cellular enzyme adenosine deaminase-1 changes the stop codon to UCG, allowing the large-HDAg to be produced

CCP in the resting state has a ferric heme, and, after the addition of two oxidizing equivalents from a hydroperoxide, it becomes an enzyme of formal oxidation state V. However, both low-temperature magnetic susceptibility measurements and Mössbauer spectroscopy show that the iron in CCP-compound I is a + 4 ferryl iron, and not in oxidation state V. The other salient feature of CCP-compound I is a long-lived free-radical, whose signal suggests a species other than the porphyrin free-radicals of other peroxidase compound I species.

" However, as noted earlier, phenethylamine is rapidly metabolized by the enzyme MAOB, preventing significant concentrations from reaching the brain, thus contributing no perceptible psychoactive effect without the use of a MAOI.

However, in his paper he was wary of identifying the enzyme with the active ion movement, so he left out the term “ sodium-potassium pump ” from the title of his paper.

However, local strand separation occurs by a process wherein the helicase enzyme is loaded at any place along the duplex.

However, three distinct aminoacyl tRNA synthetase enzyme transcripts and four unknown mRNA molecules specific to mimivirus were also found.