Although in theory the term " cardiomyopathy " could apply to almost any disease affecting the heart, in practice it is usually reserved for " severe myocardial disease leading to heart failure ".

Mild myocarditis or cardiomyopathy is frequently asymptomatic ; severe cases are associated with heart failure, arrhythmias, and systemic embolization.

Treatment depends on the type of cardiomyopathy and condition of disease, but may include medication ( conservative treatment ) or iatrogenic / implanted pacemakers for slow heart rates, defibrillators for those prone to fatal heart rhythms, ventricular assist devices ( LVADs ) for severe heart failure, or ablation for recurring dysrhythmias that cannot be eliminated by medication or cardioversion.

Patients who are most likely to benefit from the placement of an ICD are those with severe ischemic cardiomyopathy ( with systolic ejection fractions less than 30 %) as demonstrated by the MADIT-II trial.

Roosevelt reportedly suffered from various life-threatening ailments, including malignant melanoma, hypertensive cardiomyopathy, severe high blood pressure, congestive heart failure, and stroke-related symptoms ( to which he eventually succumbed ).

Younger people are likely to have a more severe form of hypertrophic cardiomyopathy

The differential diagnosis of Kussmaul's sign includes constrictive pericarditis, restrictive cardiomyopathy, pericardial effusion, and severe right-sided heart failure.

Wickes was hospitalized the following year suffering from numerous ailments, including kidney failure, massive gastrointestinal bleeding, severe low blood pressure, ischemic cardiomyopathy, anemia and breast cancer ( stage of cancer unknown ), which cumulatively resulted in her dying while undergoing surgery on October 22, 1995.

Ten months into the study, one cat in the raw diet group died suddenly from dilated cardiomyopathy due to a severe taurine deficiency.

It is evident that the requirements imposed by these effects upon any one detergent constituent acting alone are severe.

At 19 years of age, Paul enlists in the German Army and is deployed to the Western Front where he experiences the severe psychological and physical effects of the war.

Paracetamol has few side effects and is regarded as safe, although intake above the recommended dose can lead to liver damage, which can be severe and life-threatening, and occasionally kidney damage.

However, chlorpromazine proved to reduce the effects of psychosis in a more effective and specific manner than lobotomy, even though it was known to be capable of causing severe sedation.

The authors noted an apparent superior efficacy of olanzapine to the other drugs in terms of reduction in psychopathology and rate of hospitalizations, but olanzapine was associated with relatively severe metabolic effects such as a major weight gain problem ( averaging over 18 months ) and increases in glucose, cholesterol, and triglycerides.

Due to the potent combination of anticholinergic substances it contains, Datura intoxication typically produces effects similar to that of an anticholinergic delirium ( as contrasted to hallucination ): a complete inability to differentiate reality from fantasy ; hyperthermia ; tachycardia ; bizarre, and possibly violent behavior ; and severe mydriasis with resultant painful photophobia that can last several days.

In May 1985, the vessel was instrumental for ' Operation Exodus ', the evacuation of about 300 Rongelap Atoll islanders whose home had been contaminated with nuclear fallout from a US nuclear test two decades ago which had never been cleaned up and was still having severe health effects on the locals.

Determining the presence of both parts of this definition is not always straightforward, as hypoglycemic symptoms and effects are vague and can be produced by other conditions ; people with recurrently low glucose levels can lose their threshold symptoms so that severe neuroglycopenic impairment can occur without much warning, and many measurement methods ( especially glucose meters ) are imprecise at low levels.

If a person is suffering such severe effects of hypoglycemia that they cannot ( due to combativeness ) or should not ( due to seizures or unconsciousness ) be given anything by mouth, medical personnel such as EMTs and paramedics, or in-hospital personnel can establish IV access and give intravenous dextrose, concentrations varying depending on age ( infants are given 2 ml / kg dextrose 10 %, children are given dextrose 25 %, and adults are given dextrose 50 %).

The effects of the financial and economic crisis were severe.

Though ink does not easily cause death, inappropriate contact can cause effects such as severe headaches, skin irritation, or nervous system damage.

The dragging war with the Goths was a disaster for Italy, even though its long-lasting effects may have been less severe than is sometimes thought.

The drugs used to control MG either diminish in effectiveness over time ( acetylcholinesterase inhibitors ) or cause severe side effects of their own ( immunosuppressants ).

Part of the rationale for the Maginot Line stemmed from the severe French losses during the First World War, and their effects on French demographics.

Antidepressants including MAOIs have some dependence-producing effects, the most notable one being a withdrawal syndrome, which may be severe especially if MAOIs are discontinued abruptly or over-rapidly.

Methadone is also used in managing severe chronic pain, owing to its long duration of action, extremely powerful effects, and very low cost.

Since dextropropoxyphene produces relatively modest pain relief compared to other opioids but still produces severe respiratory depression at high doses, it is particularly dangerous when abused, as drug users may take dangerously high doses in an attempt to achieve narcotic effects.

These effects are dose-dependent, and in many cases severe enough to pose the risk of ulcer perforation, upper gastrointestinal bleeding, and death, limiting the use of NSAID therapy.

Later model runs in some cases predicted less severe effects, but continued to support the overall conclusion of significant global cooling.

However, a 1988 article by Brian Martin in Science and Public Policy states that although their paper concluded the effects would be less severe than originally thought, with the authors describing these effects as a " nuclear autumn ", other statements by Thompson and Schneider show that they " resisted the interpretation that this means a rejection of the basic points made about nuclear winter ".

These were far more severe than the brief Late Ordovician Ice ; but, this time, the effects on world biota were inconsequential.

Psychological effects include severe changes in body image, loss of ego boundaries, paranoia and depersonalization.

These neuropsychiatric effects included tremor, confusion, anxiety, insomnia, agitation, and, in severe cases, psychosis.

Damming and irrigation uses of the Amu Darya have had severe environmental effects on the Aral Sea, into which the river flows ( see Environmental Issues ).

This population decreased drastically around the start of the 20th century as a result of extreme fur prices which caused severe hunting also during population lows.

A person with severe dehydration due to cholera-note the sunken eyes and decreased skin turgor which produces wrinkled hands

A decreased level of consciousness occurs in 0. 5 – 6 % of severe cases, which is attributable either to infection of the brain by the virus or indirectly as a result of impairment of vital organs, for example, the liver.

If dehydration is so severe as to cause shock ( severely decreased blood pressure with insufficient blood supply to the body's organs ), or a depressed level of consciousness, rapid infusion of saline ( 1 liter for adults, 10 ml / kg in repeated doses for children ) is recommended to restore circulating volume.

The subject was said to suffer from “ agrypnia excitata ”, which consists of severe total insomnia of long duration associated with decreased vigilance, mental confusion, hallucinations, motor agitation, and complex motor behavior mimicking dreams, and autonomic activation.

Due to the severe loss of jobs, the city's population decreased by nearly 30, 000 during that period.

Other smooth muscle effects from BZ intoxication include decreased bladder tone and decreased urinary force with possibly severe bladder distention.

* any cause of hypovolemia such as prolonged vomiting, decreased oral intake, severe diarrhea

Since patients with severe AS cannot increase their cardiac output, the blood pressure falls and the patient will syncopize due to decreased blood perfusion to the brain.

The second heart sound ( A < sub > 2 </ sub >) tends to become decreased and softer as the aortic stenosis becomes more severe.

More severe cases can include signs such as cyanosis ( blue discoloration, usually of the lips and fingers ), collapse, and circulatory instability due to decreased blood flow through the lungs and into the left side of the heart.

Included among these aberrations are greatly decreased visual acuity (< 0. 1 or 20 / 200 ) in daylight Hemeralopia, nystagmus, and severe photophobia.

Grain for human consumption in the post-war years decreased, this in turn led to frequent and severe food shortages.

Symptoms include muscle weakness and cramps, paralytic ileus, ECG abnormalities, intestinal paralysis, decreased reflex response and ( in severe cases ) respiratory paralysis, alkalosis and arrhythmia.

It has been hypothesized that dissociation may provide a temporarily effective defense mechanism in cases of severe trauma ; however, in the long term, dissociation is associated with decreased psychological functioning and adjustment.

In ketoacidosis, the body fails to adequately regulate ketone production causing such a severe accumulation of keto acids that the pH of the blood is substantially decreased.

Early studies showed evidence that there may be an interhemispheric transfer deficit among alexithymics ; that is, the emotional information from the right hemisphere is not being properly transferred to the language regions in the left hemisphere, as can be caused by a decreased corpus callosum, often present in psychiatric patients who have suffered severe childhood abuse.

Pulmonary hypertension can be a severe disease with a markedly decreased exercise tolerance and heart failure.

The potassium is decreased further by the body's release of aldosterone, in an attempt to compensate for the hypovolaemia due to the severe vomiting.

If the bleeding occurs into the subarachnoid space ( subarachnoid hemorrhage ), there is usually a severe, sudden headache and decreased level of consciousness and often weakness in part of the body.

This is preferably achieved by oral rehydration therapy, although intravenous delivery may be required if a there is a decreased level of consciousness or if dehydration is severe.

In more severe cases, the bands can constrict the limb causing decreased blood supply and amputation.

It should not be used more than once in a single animal since multiple FCA inoculations can cause severe systemic reactions and decreased immune responses.