When used correctly, Methadone maintenance has been found to be medically safe and non-sedating.

After a patient has been on a maintenance programme for a period, they will be offered the opportunity to move over to a Methadone reduction programme.

This licence allows the individual to export the licenced amount and import any remaining Methadone that has not yet been used. The granting of a licence does not guarentee that the Methadone or person will be allowed entrance into the country of travel.

The analgesic effect of Methadone has been known to mask the onset of malignant disease in patients undergoing treatment with Methadone, the disease only becoming apparent when the dose ( and pain-killing effect ) of Methadone is reduced.

However, Methadone has much lower cross-tolerance, when switching to it from other opioids, than other opioids .< ref > This means that Methadone can start at a low dose, and the time for the next switch will be longer.

Methadone acts by binding to the µ-opioid receptor, but also has some affinity for the NMDA ionotropic glutamate receptor.

Methadone has a slow metabolism and very high fat solubility, making it longer lasting than morphine-based drugs.

Methadone has a typical elimination half-life of 15 to 60 hours with a mean of around 22.

Tajzadeh has written several letters from prison which have angered the authorities who have in turn put him inside Evin Prison's Methadone Ward, a ward generally reserved for hardcore criminals and drug addicts.

Methadone maintenance has been found to be medically safe and non-sedating.

Methadone has been shown to be an effective pain-reliever.

In contrast to morphine, which was used to alleviate pain in the injured but also to boost the esteem, stamina, and drive of German soldiers in combat, methadone had effects that have been described as such ; " Dolophine ( Methadone ) had many adverse effects on the soldiers to whom it was given, leading to apathy, lethargy, and decreased willingness to engage in combat ".

Methadone is considered a very helpful drug for people that use the drug the way it is prescribed.

Methadone reduction programmes are suitable for addicted persons who wish to stop using drugs altogether.

Some patients will be prescribed as much as 325 mg of methadone a day ; though a dose as low as 30 mg can prove fatal in an opiate naive individual, or in individuals who lack cross-tolerance to other opioids .. Patients prescribed Methadone for pain control, are likely to be given Methadone tablets, that come in the strength of 5mg in the Uk.

Individuals who intend to undertake overseas travel should make contact with the embassy of the intended destination to arrange for the importation of the Methadone.

Other substances can reduce the metabolism of Methadone and in such a situation, a patient who fared fine after the first few doses could reach high levels of the drug in his body without ever taking more than was prescribed.

In the UK, perons who are prescribed oral Methadone can continue to drive after they have satisfactorily completed an independent medical examination which will include a urine screen for drugs.

Methadone was first manufactured in the USA by Eli Lilly, who obtained FDA approval on August 14, 1947, for their Dolophine 5 mg and 10 mg Tablets.

Policies on dose reduction vary from clinic to clinic, from a focus on tapering the patient down to a low dose of Methadone so that they can be detoxified completely, to tapering the dose down to less than 10mg so that they are able to abstain completely.

Methadone maintenance is rarely covered by private insurance and patients are encouraged to enroll in public welfare programs or face upwards of $ 500 USD per month.

Deaths of persons recieveing Methadone are normally attributable to other factors, such as alcohol or additional drug use on top of the prescribed Methadone.

Methadone and its major metabolite, EDDP, are often measured in urine as part of a drug abuse testing program, in plasma or serum to confirm a diagnosis of poisoning in hospitalized victims, or in whole blood to assist in a forensic investigation of a traffic or other criminal violation or a case of sudden death.

These medicines are often sold by drug dealers, especially those marked as " CD POM ," which are controlled due to abuse risk such as Diconal, Temazepam, and Methadone.

In chronic pain conditions that are opioid responsive a combination of a long-acting ( Oxycontin, MS Contin, Opana ER, Exalgo and Methadone ) or extended release medication is often prescribed in conjunction with a shorter-acting medication ( oxycodone, morphine or hydromorphone ) for breakthrough pain, or exacerbations.

Methadone and buprenorphine are maintenance therapies intended to reduce cravings for opiates, thereby reducing illegal drug use, and the risks associated with it, such as disease, arrest, incarceration, and death, in line with the philosophy of harm reduction.

* The Trench Methadone Clinic and the David Trench Rehabilitation Clinic, both in Hong Kong, are named after him.

Methadone clinics are only for recovering addicts from opiates.

The treatment of opiate addicted persons with Methadone will follow one of two routes.

MMT ( Methadone Maintenance Treatment ), a form of opioid replacement therapy, reduces and / or eliminates the use of illicit opiates, the criminality associated with opiate use, and allows patients to improve their health and social productivity.

On November 29, 2006, the U. S. Food and Drug Administration issued a Public Health Advisory about methadone titled " Methadone Use for Pain Control May Result in Death and Life-Threatening Changes in Breathing and Heart Beat.

In 2006, the U. S. Food and Drug Administration issued a caution about methadone, titled “ Methadone Use for Pain Control May Result in Death .” The FDA also revised the drug's package insert.

A common problem in treating methadone overdoses is that, given the short action of Naloxone ( versus the extremely longer-acting Methadone ), a dosage of Naloxone given to a Methadone-overdosed patient will initially work to bring the patient out of overdose, but once the Naloxone wears off, if no further Naloxone is administered, the patient can go right back into overdose ( based upon time and dosage of the Methadone ingested ).

) Methadone Anonymous is similar to NA, but considers the use of methadone to be a tool of recovery and not a drug.

Methadone ( methadone )***.

( 1997 ) Neurobiology of Heroin Addiction and Methadone Treatment, a paper written for the 1997 American Association for the Treatment of Opioid Dependence methadone conference, retrieved December 12, 2004.

# REDIRECT Methadone clinic

Methadone can provide a method of stable treatment of the symptoms associated with withdrawal and mental anguish, and, with a proper slow taper, can be discontinued after the patient feels he or she is ready, often after a year or more, which gives the addict time to get away from old habits or triggers.

Methadone ( also known as Symoron, Dolophine, Amidone, Methadose, Physeptone, Heptadon and many other names ) is a synthetic opioid, used medically as an analgesic and a maintenance anti-addictive and reductive preparation for use by patients with opioid dependency.

When an individual is leaving the UK with an amount of Methadone that exceeds 500mg, a Home Office Export Licence is required which should be arranged by the prescriber.

Methadone, with its long half-life ( and thus long duration of effect ) and good oral bioavailability, is a common second-choice drug for pain that does not respond to weaker agonists.

Many patients report that Methadone's sedation effect is often less pronounced than with other opioids and cite this as a major argument for preferring Methadone as an analgesic .< ref > Persons reciveing MMT should not suffer from extreme sedation as a resullt of the treatment, due to the fact that a properly prescribed person will have had their dose titrated up to the optimal level to remove the effects of withdrawl, a point at which sedation should not be evident.