MicroRNAs occur naturally, and by harnessing this endogenous pathway it should be possible to achieve similar gene knockdown at comparatively low concentrations of resulting siRNAs.

MicroRNAs, or miRNAs for short, are small (~ 22nt ) segments of RNA which have been found to play a crucial role in gene regulation.

MicroRNAs bound to the 3 ' UTR also may affect translational efficiency or mRNA stability.

MicroRNAs ( miRNAs ) are small RNAs that typically are partially complementary to sequences in metazoan messenger RNAs.

MicroRNAs ( miRNA ; 21-22 nt ) are found in eukaryotes and act through RNA interference ( RNAi ), where an effector complex of miRNA and enzymes can cleave complementary mRNA, block the mRNA from being translated, or accelerate its degradation.

MicroRNAs are predicted to control the translational activity of approximately 30 % of all protein-coding genes in mammals and may be vital components in the progression or treatment of various diseases including cancer, cardiovascular disease, and the immune system response to infection.

Only recently new `` holes '' were discovered in our safety measures, and a search is now on for more.

When he discovered they had received from the Company's Court of Directors no permission to live in India, coupled with the fact that they were Americans who had been sent to Asia to convert `` the heathen '', he became more belligerent than ever.

From this point of view the `` militant mobs '' of the past, stirred into action by one ideology or another, were all composed of `` intellectuals '' -- and this is not the level on which the essence of mankind can be discovered.

It would be even more valuable because that same aircraft could immediately destroy any targets it discovered -- no need to wait for a missile to come all the way from the United States with the chance that the target, if it were mobile, would be gone.

I discovered that the girls had shrewdly vacated the kitchen, and were playing quietly in the living room.

One morning, we discovered not only that the pennies were missing from the idol but that a cigarette had been stubbed out in its lap.

Final ratings were made on the basis of a point system which was developed after studying the distributions of actual behaviors recorded and assigning weight values to each type of behavior that was deviant from the discovered norms.

In this manner, the factors measured by the intelligence test were controlled, allowing discovered differences in achievement to be interpreted as resulting from other variables.

Early in her life she had discovered that where there were men, there was money, and with the two came luxury and liquor.

I discovered in the course of a visit there that almost all the pupils were Negroes.

After returning to the United States and raising the money, he discovered on getting back to Japan that the hours were no longer available.

They lay months away from the nearest Earth star by jump drive, and no one knew what they were good for, although it was felt that they would probably be good for something if it could only be discovered -- much like the continent of Antarctica in ancient history.

Anton van Leeuwenhoek, the famous 17th century microscopist, discovered living organisms ( living, because they were motile ) in deposits on the teeth ( what we now call dental plaque ).

These terms have historically been applied to any astronomical object orbiting the Sun that did not show the disk of a planet and was not observed to have the characteristics of an active comet, but as small objects in the outer Solar System were discovered, their volatile-based surfaces were found to more closely resemble comets, and so were often distinguished from traditional asteroids.

The physicist J. J. Thomson, through his work on cathode rays in 1897, discovered the electron, and concluded that they were a component of every atom.

In 1909, Hans Geiger and Ernest Marsden, under the direction of physicist Ernest Rutherford, bombarded a sheet of gold foil with alpha rays — by then known to be positively charged helium atoms — and discovered that a small percentage of these particles were deflected through much larger angles than was predicted using Thomson's proposal.

Archaeologist Timothy A. Kohler excavated large Pueblo I sites near Dolores, Colorado, and discovered that they were established during periods of above-average rainfall.

In 1906, precipitation hardening alloys were discovered by Alfred Wilm.

The first few amino acids were discovered in the early 19th century.

These were discovered by Carl D. Anderson in 1932 and named positrons ( a contraction of " positive electrons ").

James I's courtiers discovered in " James Stuart " " a just master ", and converted " Charles James Stuart " into " Claims Arthur's seat " ( even at that point in time, the letters I and J were more-or-less interchangeable ).

In Lebanon more than 450 outcrops of Lower Cretaceous amber were discovered between the 1960s and 1990s, among which about 20 outcrops have yielded biological inclusions comprising the oldest representatives of several recent families of terrestrial arthropods.

Many remarkable insects and spiders were recently discovered in the amber of Jordan including the oldest zorapterans, clerid beetles, umenocoleid roaches, and achiliid planthoppers.

Among the important novelists of the 1980s were Rachid Mimouni, later vice-president of Amnesty International, and Tahar Djaout, murdered by an Islamist group in 1993 for his secularist views.

They were furthered by American Spectator writer David Brock in his 1993 book The Real Anita Hill, though he later recanted the claims he had made, described his book as " character assassination ", and apologized to Hill.

The 1993 State Civil Servant Provisional Regulations ( 国家公务员暂行条例 ) changed the way government officials were selected and promoted, requiring that they pass exams and yearly appraisals, and introduced a rotation system.

In May 1992 the Belorussian Military District was abolished, and on January 1, 1993 all service personnel on Belarussian soil were required to either take an oath of loyalty to Belarus, or leave.

The six ex-Philippine SF. 260WP aircraft were taken out of service in 1993 and returned to their previous owner, although the four newly-built SF. 260WP aircraft were retained in service, and stationed at Bobo Dioulasso air base.

Goat rearing has been promoted as a source of income for rural-dwelling Burundians. IMF structural adjustment programs in Burundi were suspended following the outbreak of the crisis in 1993.

Over 4 million Cambodians ( about 90 % of eligible voters ) participated in the May 1993 elections, although the Khmer Rouge or Party of Democratic Kampuchea ( PDK ), whose forces were never actually disarmed or demobilized, barred some people from participating.

Regarding economic assistance, official donors had pledged $ 880 million at the Ministerial Conference on the Rehabilitation of Cambodia ( MCRRC ) in Tokyo in June 1992, to which pledges of $ 119 million were added in September 1993 at the meeting of the International Committee on the Reconstruction of Cambodia ( ICORC ) in Paris, and $ 643 million at the March 1994 ICORC meeting in Tokyo.

In 1993 Mauritius and Seychelles had two of the five embassies in Moroni, and Mauritius and Madagascar were connected to the republic by regularly scheduled commercial flights.

By 1993, the Federal Emergency Management Agency had made the program available nationwide ; by 2012, CERT programs were offered in all 50 states, the District of Columbia, Puerto Rico and the Northern Mariana Islands.

Coming of age was dealt with in Good Will Hunting ( 1997 ), race relationships were a theme in American History X ( 1998 ), and the AIDs epidemic and discrimination were the focus of Philadelphia ( 1993 ).

Commemorative signs reading " Eisenhower Interstate System " and bearing Eisenhower's permanent 5-star rank insignia were introduced in 1993 and are currently displayed throughout the Interstate System.

The Clinton Administration on December 21, 1993, issued Defense Directive 1304. 26, which directed that military applicants were not to be asked about their sexual orientation.

The website and collection of books were started in 1993 by Wendy Northcutt, who at the time was a graduate in molecular biology from the University of California, Berkeley.

Carol died in 1993 from the sudden onset of a brain tumor – glioblastoma multiforme – when their children were five and two.

The West Memphis Three are three men who were tried and convicted as teenagers in 1994 of the 1993 murders of three boys in West Memphis, Arkansas.

Three eight-year-old boys — Stevie Branch, Michael Moore, and Christopher Byers — were reported missing on May 5, 1993.

On May 6, 1993 ( the day the murder victims were found ), Hutcheson took a polygraph exam by Detective Don Bray at the Marion Police Department to determine if she had stolen money from her West Memphis employer.

On June 2, 1993, Hutcheson told police that about two weeks after the murders were committed, she, Echols and Misskelley attended a Wiccan meeting in Turrell, Arkansas.

Initially the owners of AOI were the governments of Egypt, Saudi Arabia, and the United Arab Emirates, before the latter governments gave their shares back to Egypt in 1993, valued at $ 1. 8 billion.

* Al-Aqsa Martyrs ' Brigades – The al-Aqsa Martyrs Brigades were created in the Second Intifada to bolster the organization's militant standing vis-à-vis the rival Hamas movement, which had taken the lead in attacks on Israel after 1993, and was gaining rapidly in popularity with the advent of the Intifada.

The 1991 semi-final between Arsenal and Tottenham was the first to be played at Wembley, as were both 1993, 1994 and 2000 semi-finals.

In 1993, de Klerk and Mandela were jointly awarded the Nobel Peace Prize for their work ending apartheid.