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Mutations that deactivate p53 in cancer usually occur in the DBD.
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Mutations and cancer
Mutations in BRCA1 and BRCA2, important risk factors for ovarian cancer and breast cancer in women, have also been implicated in prostate cancer.
Mutations in either of two major susceptibility genes, breast cancer susceptibility gene 1 ( BRCA1 ) and breast cancer susceptibility gene 2 ( BRCA2 ), confer a lifetime risk of breast cancer of between 60 and 85 percent and a lifetime risk of ovarian cancer of between 15 and 40 percent.
Mutations in the pathway in adults promote degenerative disease and cancer.
Mutations in this gene could be involved in the malignant progression of colon cancer.
Mutations affecting EGFR expression or activity could result in cancer.
Mutations that lead to EGFR overexpression ( known as upregulation ) or overactivity have been associated with a number of cancers, including lung cancer, anal cancers and glioblastoma multiforme.
Mutations involving EGFR could lead to its constant activation, which could result in uncontrolled cell division – a predisposition for cancer.
Mutations in genes encoding these proteins can lead to inactivation of cadherin cell adhesions and elimination of contact inhibition, allowing cells to proliferate and migrate, thus promoting tumorigenesis and cancer development.
* Mutations in catenin genes can cause loss of contact inhibition that can promote cancer development and tumor formation.
Mutations in DNA that lead to cancer ( only certain mutations can lead to cancer and the majority of potential mutations will have no bearing ) disrupt these orderly processes by disrupting the programming regulating the processes.
Mutations of tumor suppressor genes that occur in germline cells are passed along to offspring, and increase the likelihood for cancer diagnoses in subsequent generations.
Mutations in the DNA glycosylase MYH are also known to increase susceptibility to colon cancer.
Mutations and usually
Mutations can involve large sections of DNA becoming duplicated, usually through genetic recombination.
Mutations can involve large sections of DNA becoming duplicated, usually through genetic recombination.
Mutations are permanent, transmissible changes to the genetic material ( usually DNA or RNA ) of a cell.
Mutations can involve large sections of DNA becoming duplicated, usually through genetic recombination.
Mutations usually sound at pitches in the harmonic series of the fundamental and, except where they are derived from unit ranks, are always tuned pure.
Mutations are permanent, transmissible changes to the genetic material ( usually DNA or RNA ) of a cell.
Mutations that cause the altered codon to produce an amino acid with similar functionality ( i. e. a mutation producing leucine instead of isoleucine ) are often also classified as silent ; if the properties of the amino acid are conserved, this mutation does not usually significantly affect protein function.
Mutations and occur
Mutations are changes in the DNA sequence of a cell's genome and are caused by radiation, viruses, transposons and mutagenic chemicals, as well as errors that occur during meiosis or DNA replication.
Mutations can have an impact on the phenotype of an organism, especially if they occur within the protein coding sequence of a gene.
Mutations are caused by radiation, viruses, transposons and mutagenic chemicals, as well as errors that occur during meiosis or DNA replication.
Mutations can be caused by copying errors in the genetic material during cell division and by exposure to radiation, chemicals, or viruses, or can occur deliberately under cellular control during the processes such as meiosis or hypermutation.
Mutations periodically occur within the Y chromosome and these mutations are passed on to males in subsequent generations.
Mutations occur mainly in exons 2, 3, 5 and 10.
Mutations generally occur in the DNA encoding the intracellular part ( exon 11 ), which acts as a tyrosine kinase to activate other enzymes.
Mutations in the exons 11, 9 and rarely 13 and 17 of the c-kit gene are known to occur in GIST.
Mutations within the dystrophin gene can either be inherited or occur spontaneously during germline transmission.
Mutations that occur early on in development will affect a greater number of cells and can result in an individual that can be identified as a mosaic strictly based on phenotype.
# Mutations occur in the same gene.
Mutations and .
Mutations and natural selection result in a species acquiring new traits and eventually evolving into one or more new species.
game as well as adding sophisticated new rule systems specific to the setting ( e. g. Mutations and ' Weird Science ').
Mutations in the gene for the prion protein can cause a misfolding of the dominantly alpha helical regions into beta pleated sheets.
Mutations of the corresponding gene in mice ( FOXP2 is fairly well conserved ; modern humans share the same allele as Neanderthals ) cause reductions in size and vocalization rate.
Mutations in several genes have been linked to several types of epilepsy.
One deck represents random Alpha Mutations, which can be drawn to gain temporary powers, and the other contains various Omega Tech, powerful technological devices that could possibly backfire on those that use them.
Mutations in two regulatory genes of white grapes turn off production of anthocyanins which are responsible for the color of purple grapes.
Mutations in the genes for the hemoglobin protein in a species result in hemoglobin variants.
Mutations of the thyroid-stimulating hormone receptor that cause a constitutive activation of the thyroid gland cells have been discovered recently.
Mutations in the gene HR can lead to complete hair loss, though this is not typical in humans.
Mutations in such microRNAs ( known as oncomirs ) can lead to activation of oncogenes.
Mutations in transpeptidases that lead to reduced interactions with an antibiotic are a significant source of emerging antibiotic resistance.
Mutations in viral genes weakened their infectious ability, sometimes creating viruses that were able to infect and grow within only certain varieties of E coli.
Mutations du surréalisme de l ' exil américain à l ' écart absolu ( 1941 – 1965 ), Les presses du réel, Dijon, 2007.
Mutations of the Chardonnay grape include the rare pink-berried " Chardonnay Rose "; also " Chardonnay Blanc Musqué ", which produces an intensely aromatic wine.
Mutations in genes can cause also affect skin colour through oculocutaneous albinism ( OCA ) – a lack of pigment in the eyes, skin and sometimes hair that occurs occasionally in a very small fraction of the population.
Mutations of this very polymorphic gene, such as Arg151Sys ( rs1805007 ), Arg160Trp ( rs1805008 ), Asp294Sys ( rs1805009 ), Val60Leu ( rs1805005 ) and Val92Met ( rs2228479 ) have been shown to cause red hair and pale skin that does not tan in a small percentage of the human population.
Mutations are an important force driving evolution.
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