Once activated, these exchange factors can activate more small G proteins, thus amplifying the receptor's initial signal.

Once an all-human endeavor based mainly upon changes in barometric pressure, current weather conditions, and sky condition, weather forecasting now relies on computer-based models that take many atmospheric factors into account.

Once the vesicles reach their targets, they come into contact with tethering factors that can restrain them.

Once this has been achieved, loss of control causing fecal incontinence may be caused by physical injury – such as damage to the anal sphincter that may result from an episiotomy, intense fright, excessive pressure placed upon the abdomen, inflammatory bowel disease, impaired water absorption in the colon ( diarrhea ), and psychological or neurological factors.

Once a vital ritual in many of the world's monarchies, coronations have changed over time due to a variety of socio-political and religious factors to the point that most modern monarchies have dispensed with them altogether, preferring simpler enthronement, investiture, or benediction ceremonies.

Once again, previously acquired injuries were the major factors in this loss.

Once exposed, the likelihood of an animal becoming infected is variable, depending on age, pregnancy status, and other intrinsic factors of the animal, as well as the amount of bacteria to which the animal was exposed.

Once these factors have been determined, educators decide which curriculum content, learning activities, products, and learning environments will best serve those individual students ’ needs.

Once in the cytoplasm after the pioneer round of translation, the CBC is replaced by the translation factors eIF-4E and eIF-4G.

Once the sample is generated, several strategies ( including simple input-output scatterplots ) can be used to derive sensitivity measures for the factors.

Once freed from JAZ, transcription factors can activate genes needed for a specific JA response.

Once introduced to a country its spread has been influenced by many local factors including blood transfusions, vaccination programmes, intravenous drug misuse and treatment regimes.

Once one considers the possibility that labor can be seen as an intermediate surrogate for more fundamental factors, like know-how, materials and energy, then it is a short step to treat ( as Boulding sometimes does ) capital as a surrogate for know-how and land as surrogate for material resources and the traditional factors of production, land, labor and capital, are easily rearticulated as know-how, energy and materials.

Once other crime-associated factors were properly controlled for, the effect of abortion on arrests was reduced by about half.

Once the jury found that one or more of the aggravating factors existed beyond a reasonable doubt, then the defendant would be eligible for the death penalty.

Once activated the cells undergo several key morphological changes including the thickening and retraction of branches, uptake of MHC class I / II proteins, expression of immunomolecules, secretion of cytotoxic factors, secretion of recruitment molecules, and secretion of pro-inflammatory signaling molecules ( resulting in a pro-inflammation signal cascade ).

Once the facility is built, it operates more or less autonomously and will produce the specified resource at a rate determined by various factors including the richness of the deposit in that area.

Once the term " organic " became regulated, many other factors were added.

Once the activated transcription factors reaches the nucleus it binds to consensus DNA-recognition motif called gamma activated sites ( GAS ) in the promoter region of cytokine inducible genes and activates transcription of these genes.

Once again, he shook his head, kept his face expressionless and his voice very calm, and had a strongly supported alibi ready.

Once Todman thought he had spotted a tank and went down to investigate while Greg covered him.

Once I had a religious emotion.

Once out of the gate they had charged straight up the narrow lane.

Once covertly looking at Simms Purdew, the only man in the world whom he hated, he had seen the heavy, slack, bestubbled jaw open and close to emit the cruel, obscene banter, and had seen the pale-blue eyes go watery with whisky and merriment, and suddenly he was not seeing the face of that vile creature.

Once there had been big glittering rooms where Ulanys bowed and kissed the ladies' hands as they flirted from behind their fans.

Once the full extent of this Russian military penetration of Cuba was clear, President Kennedy announced we would take whatever action was appropriate to prevent this, even if we had to go it alone.

Once the soldiers from the barracks had to hold the ship from blowing away while Fogg revved the engine and got the tail up.

Once, after the Discovery lay for a week in rough weather, Hudson ordered the anchor raised before the sea had calmed.

Once he had abandoned himself to the very worst, once he had quieted all the dragons of worry and suspense, there wouldn't be very much for Mae to do.

Once, in New York, he had gone flying with some friends in a small private airplane with a single engine.

Once the Old Man had had a wife.

Once the soft, pretty moth found the bright light she had always wanted??

Once before I had been to Paris, long before I married Valery.

Once burned -- scalded, really, because Vivian had given him every encouragement -- forever shy.

Once, like you, I had one head, two hands, ten fingers on my hands.

Once Pan had the audacity to compare his music with that of Apollo, and to challenge Apollo, the god of the kithara, to a trial of skill.

Once again Abd al-Rahman had to be concerned with developments in the Upper March.

Once he had established himself as sole ruler of the Roman state in 30 BC, Caesar's grand-nephew and adopted son Augustus inaugurated a strategy of advancing the empire's southeastern European border to the line of the Danube from the Alps, the Dinaric Alps and Macedonia.

Once war had begun, Hitler urged his economic experts to abandon caution and expend all available resources on the war effort.

Once the keys had been pressed they were locked down until mechanical contacts in a distributor unit passed over the sector connected to that particular keyboard, when the keyboard was unlocked ready for the next character to be entered, with an audible click ( known as the " cadence signal ") to warn the operator.

Once again, though, the team's pitching was a glaring weakness, as the staff had an ERA of 6. 02.