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Once the vesicles reach their targets, they come into contact with tethering factors that can restrain them.
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Once and vesicles
Once in the cytoplasmic space, tyramine will be transported via the vesicular monoamine transporter ( VMAT ) into synaptic vesicles, thereby displacing norepinephrine.
Once back in the cytosol, it is subsequently repackaged into vesicles by VMAT2.
Once the vesicles have docked with the SNARE proteins, they swell, which increases their internal pressure.
Once endocytic vesicles have uncoated, they fuse with early endosomes.
Once opsonized, the clathrin-coated vesicle uncoats ( a pre-requisite for the vesicle to fuse with other membranes ) and individual vesicles fuse to form the early endosome.
Once and reach
Once, then -- for how many years or how few does not matter -- my world was bound round by fences, when I was too small to reach the apple tree bough, to twist my knee over it and pull myself up.
Once a city expands far enough to reach another city, this region can be deemed a conurbation or megalopolis.
Once the cholera bacteria reach the intestinal wall, they no longer need the flagella to move.
Once this In-Orbit Validation ( IOV ) phase has been completed, additional satellites will be launched to reach Initial Operational Capability ( IOC ) around mid-decade.
Once this In-Orbit Validation ( IOV ) phase has been completed, the remaining satellites will be installed to reach the Full Operational Capability.
Once more, Amitabha came to her aid and appointed her a thousand arms to let her reach out to those in need.
# Once the applicable law is decided, that law must be proved before the forum court and applied to reach a judgment.
Once in air, pterosaurs could reach speeds up to and travel thousands of kilometres.
Once the rays reach the eye, the eye traces them back as straight lines ( lines of sight ).
Once person B sits on the shoulders of person A, they are tall enough to reach the apple.
Once they reach the plain, the rivers slow down and the waters meander across flood plains and deltas.
Once they reach it, Miller locates a friend of Ryan's, who reveals that Ryan is defending a strategically important bridge over the Merderet River in the town of Ramelle.
Once they reach their prey, they touch it very softly with their antennae to assess its size and nutritional value.
Once such cells reach a certain minimum size, rather than simply divide vegetatively, they reverse this decline by forming an auxospore.
Once the North Pole had been reached in 1909, several expeditions attempted to reach the South Pole.
Once the rays reach the viewer ’ s eye, the visual cortex interprets it as if it traces back along a perfectly straight " line of sight ".
Once Allied ground forces had captured islands sufficiently close to Japan, airfields were built on those islands ( particularly Saipan and Tinian ) and B-29s could reach Japan for bombing missions.
Once deputies reach the GS-11 pay grade, they are reclassified as 1811 Criminal Investigators.
Once symptoms appear, they may progress rapidly and reach peak intensity in as little as three days.
Once they reach adulthood, jerboas usually have their own burrow and search for food on their own, not in groups.
Once they reach the surface, they instinctively head towards the sea.
Once stable, the foreshore should widen and become more effective at dissipating the wave energy, so that fewer and less powerful waves reach beyond it.
Once fused to a female, the males will reach sexual maturity, developing large testicles as their other organs atrophy.
Once safely out of the posse's reach, they gave vent to their anger by firing on the intruders.
Once and their
Once we send out the whole pie, they can put their pieces into it.
Once there had been big glittering rooms where Ulanys bowed and kissed the ladies' hands as they flirted from behind their fans.
Once these conditions of international law are met, countries that try to run the blockade do so at their own risk.
Once many significant phrases are found in theory or in recurrent practice to provide for prosodic necessity, they are not to be defended for their semantic properties in isolated contexts.
Once four Tibetan monks, in their saffron robes, filed through the cafeteria line.
Once he has received this blessing, the abbot not only becomes father of his monks in a spiritual sense, but their major superior under canon law, and has the additional authority to confer the ministries of acolyte and lector ( formerly, he could confer the minor orders, which are not sacraments, that these ministries have replaced ).
Once inside the fortification, Alfred realised, the Danes enjoyed the advantage, better situated to outlast their opponents or crush them with a counter attack as the provisions and stamina of the besieging forces waned.
Once a forecasting error is made by agents, due to a stochastic shock, they will be unable to correctly forecast the price level again even if the price level experiences no further shocks since they only ever incorporate part of their errors.
Once it has come to rest, the jack is aligned to the centre of the rink and the players take turns to roll their bowls from the mat towards the jack and thereby build up the " head ".
Once the proposal is accepted by both the creditors and the Court, the debtor makes the payments to the Proposal Administrator each month ( or as otherwise stipulated in their proposal ), and the general creditors are prevented from taking any further legal or collection action.
Once adsorbed, the bonds within the reacting molecules are weakened, and new bonds between the resulting fragments form in part due to their close proximity.
Once the Swiss developed their pike squares for offensive as well as defensive use, infantry started to become the principal arm.
Once the round has ended, surviving players retain their equipment for use in the next round ; players who were killed begin the next round with the basic default starting equipment.
Once Chuck Peddle had taken over engineering at Commodore, he convinced Jack Tramiel that calculators were already a dead end and that they should turn their attention to home computers.
Once Mussolini had fallen in Italy, the Allies switched their attention to the mainland with Operation Avalanche.
Once he left Moina, Almagro followed the Inca trail followed by 750 Spaniards deciding to join him in quest for the gold lost in the ransom of Atahualpa, which had mainly benefited the Pizarro brothers and their supporters.
Once a diver is completely under the water they may choose to roll or scoop in the same direction their dive was rotating to pull their legs into a more vertical position.
Roger Ebert approves of the use of the label in unsuccessful films that had been tampered with by studio executives, such as Sergio Leone's original cut of Once Upon a Time in America, and the moderately successful theatrical version of Daredevil, which were altered by studio interference for their theatrical release.
Once again Afghanistan provided a stage on which the great powers played out their schemes against one another.
Once there, the relics made it known they were unhappy with their new tomb and thus had to be moved again to Mulinheim.
Once engaged in combat, however, they must use an action to do so ( called re-attuning on the fly ), which requires a set difficulty they must achieve, or risk losing their turn.
Once an avid reader, he has come to hate books due to their unpleasant content and contradicting facts and opinions.
Once there, they refused to recognise Gregory's position as head of the church of Constantinople, arguing that his transfer from the See of Sasima was canonically illegitimate because one of the canons of the Council of Nicaea had forbidden bishops to transfer from their sees.
Once again, however, a critical situation for the Axis forces was retrieved by vigorous counter-attacks from hastily assembled German and Italian forces, which forced the Australians to withdraw back to their start line with 300 casualties.
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