Once activated, they migrate to the lymph nodes where they interact with T cells and B cells to initiate and shape the adaptive immune response.

Once at the lymph nodes, the APC begin to present antigen peptides that are bound to Class II MHC, allowing CD4 < sup >+</ sup > T cells that express the specific TCRs against the peptide / MHC complex to activate.

Once below the skin, the bacteria can spread rapidly, entering the lymph nodes and the bloodstream and spreading throughout the body.

Once oropharyngeal cells become infected the virus spreads to dividing lymph cells and continues to work to the bone marrow and spread to target organs through blood.

Once across the intestinal barrier, they are reformed into triglycerides and packaged into chylomicrons or liposomes, which are released into the lacteals, the capillaries of the lymph system and then into the blood.

Once this is done the APC moves down the lymphatic system to a lymph node where it presents this part of the substance ( what we now call an antigen ) to a particular immune cell called a CD4 + T-cell or T-helper cell.

Once the term of a copyright has expired, the formerly copyrighted work enters the public domain and may be freely used or exploited by anyone.

Once the Euphrates enters the Upper Mesopotamian plains, its grade drops significantly ; within Syria the river falls while over the last stretch between Hīt and the Shatt al-Arab the river drops only.

Once the Euphrates enters Iraq, there are no more natural tributaries to the Euphrates, although canals connecting the Euphrates basin with the Tigris basin exist.

Once insulin enters the human brain, it enhances learning and memory and benefits verbal memory in particular.

Once a vehicle leaves low earth orbit and the protection of Earth's magnetosphere, it enters the Van Allen radiation belt, a region of high radiation.

Once the vaulter enters the competition, they can choose to pass heights.

Once the Poynting vector enters the conductor, it is bent to a direction that is almost perpendicular to the surface.

Once the chilling period is met, the plant enters the so-called quiescence period, the second type of dormancy.

Once a low energy particle enters the counter, it is possible that the kinetic energy in addition to the potential energy of the voltage are insufficient for the additional ionization to occur and thus the ion recombines.

Once the neutron star enters the red giant, drag between the neutron star and the outer, diffuse layers of the red giant causes the binary star system's orbit to decay, and the neutron star and core of the red giant spiral inward toward one another.

Once the nitrogen enters the estuaries via groundwater, it is thought that because there is more < sup > 15 </ sup > N entering, that there will also be more < sup > 15 </ sup > N in the inorganic nitrogen pool delivered and that it is picked up more by producers taking up N. Even though < sup > 14 </ sup > N is easier to take up, because there is much more < sup > 15 </ sup > N, there will still be higher amounts assimilated than normal.

Once the protostar enters into its main sequence phase, it is classified as a star.

Once in twelve years, when the planet Guru ( Jupiter ) enters Simha ( Leo ) sign, the Kumbh mela festival of South India is celebrated at Mahamaham tank.

Once a mobile has parsed all the network overhead information, it registers with the network, then optionally enters slotted-mode.

Once EBV enters the cell, the viral capsid dissolves and the viral genome is transported to the cell nucleus.

Once deposited, the bacterium enters the plant through open stomata and causes blackened, necrotic lesions, which may also produce a viscous exudate.

Once these rituals are completed, Taleju enters her and she is presented as the new Kumari.

Once the A2 enters Kent, the speed limit increases to the national speed limit ( 70 mph, 113 km / h ) and the road heads east towards Dartford, bypassing the town to the south and cutting through Dartford Heath.

Once the tube is past the pharynx and enters the esophagus, it is easily inserted down into the stomach.

Once the air bubble becomes smaller and more water enters the diver, the diver displaces a weight of water that is less than its own weight, so it becomes negatively buoyant and sinks in accordance with Archimedes ’ principle.

Once air enters the lungs, diffusion of O < sub > 2 </ sub > and CO < sub > 2 </ sub > occurs in the alveoli.

Once it enters Rochester, it has a concurrency with U. S. Route 52.

Once the court ( the judge ) receives the verdict, the judge enters judgment on the verdict.

Once a mark enters the circle of apparent players and faces the operator, the gang surrounds the player to discourage an easy exit and to keep other pedestrians from entering and disrupting the confidence trick gang's action on the main mark.

Once fully extended, the tentacles are slowly manoeuvred around waiting for contact with a suitable prey animal.

Once that was done the simple version of Kermit could be used to download a fully functional version.

Once the cakes have fully dried, the graphite and the clay squares and are mixed together using water.

Once the eggs are fully developed, the female lays them and resumes host-seeking.

Once fully deployed, the system is used for its intended operational role and maintained within its operational environment.

Once the yolk has been fully absorbed, the young walleye begins to feed on invertebrates, such as fly larvæ and zooplankton.

* Once ingested, the larva will remain dug into a villus in the small intestine for about 2 – 3 days until it is fully developed for migration to the ileo-cecum section of the gastrointestinal tract.

Once all assets of the corporate or partnership debtor have been fully administered, the case is closed.

Once a large influx of Fuzhou immigrants came in, the eastern portion of Chinatown became more fully developed as being part of Chinatown and establishing their own Fuzhou community primarily on the East Broadway and Eldridge Street portion, which has resulted in referring East Broadway as Fuzhou Street No. 1 and Eldridge Street as Fuzhou Street No. 2 becoming known as the New Chinatown of Manhattan separate from the long time heavily dominated Cantonese community, which is the western section of Chinatown or the Old Chinatown of Manhattan.

Once fully established, the sanatorium was the relocation center for all white Arkansans with tuberculosis.

Once all these powerful rulers had firmly established themselves within their respective dominions, the bloodshed focused more fully on interstate conflict in the Warring States Period, which began in 403 BC when the three remaining elite families in Jin – Zhao, Wei and Han – partitioned the state.

Once he is fully recovered, Jopin recognises Corwin, and shows him that the Vale of Garnath, previously a pleasant valley adjacent to Amber, has become a warped and twisted evil place.

Once fully developed, the facility is projected to employ 600 scientists and technicians.

Once it fully sinks to the floor of the fluid or rises to the surface and settles, Archimedes principle can be applied alone.

Once it was fully armed and manned, Perry's superior squadron instituted a counter-blockade of Amherstburg, and supplies of food there rapidly ran short.

Once fully demodulated at the receiver, adding the two together yields the left channel again ( L + R + ( L − R )

Once it is fully open and dry, the seed can be easily extracted in various ways.

Once a team loses its DH under any of the scenarios discussed in the previous paragraph, the double switch becomes fully available, and may well be used via necessity, should the former DH be replaced in the lineup.

Once hatched, the nestlings are active and have their eyes fully or half open, additionally they display a sparing cover of soft down feathers.

Once the covenant is made, the convert is fully immersed in water ( unless they are physically unable to do so ).

Once this information has been fully reviewed by credit officers and credit committees, the lender provides the funds subject to the terms and conditions presented within the contract ( as outlined above ).

Once the damaged tunnel was repaired by Metronet engineers, the line was reopened, also allowing the Metropolitan line to be fully restored, since the closure had meant all trains had terminated two stations early at Moorgate.

Once the mortgage had been fully repaid, the Wintertons transferred the ownership of the flat into a family trust.

Once this procedure was fully described, his next step was to program the algorithms into a computer and let the computer search for the best codes.