One growth center in a short bone -- distal phalanx of the second finger -- was chosen as an example for discussion here, primarily because epiphyseal-diaphyseal fusion, the maturity indicator for Completion in long and short bones, occurs in this center for girls near the menarche and for boys near their comparable pubescent stage.

The brain signals the bone to grow instead of scar tissue to form, and nodules and other growth can interfere with prosthetics and sometimes require further operations.

* Growth factor storage — mineralized bone matrix stores important growth factors such as insulin-like growth factors, transforming growth factor, bone morphogenetic proteins and others.

* Endocrine organ — bone controls phosphate metabolism by releasing fibroblast growth factor – 23 ( FGF-23 ), which acts on kidneys to reduce phosphate reabsorption.

Recent research has suggested that certain growth factors may work to locally alter bone formation by increasing osteoblast activity.

Numerous bone-derived growth factors have been isolated and classified via bone cultures.

These factors include insulin-like growth factors I and II, transforming growth factor-beta, fibroblast growth factor, platelet-derived growth factor, and bone morphogenetic proteins.

Evidence suggests that bone cells produce growth factors for extracellular storage in the bone matrix.

The release of these growth factors from the bone matrix could cause the proliferation of osteoblast precursors.

Essentially, bone growth factors may act as potential determinants of local bone formation.

For example, bone morphogenic proteins stimulate bone cell differentiation, while fibroblast growth factors and vascular endothelial growth factors stimulate blood vessel differentiation ( angiogenesis ).

The three main mechanisms by which osteoporosis develops are an inadequate peak bone mass ( the skeleton develops insufficient mass and strength during growth ), excessive bone resorption, and inadequate formation of new bone during remodeling.

Zwingli's time as the pastor of Glarus and Einsiedeln was characterized by inner growth and development.

The juvenile mantle tissue cells, according to their stage of growth, produce columnar calcium carbonate, which is secreted from the inner surface of the pearl sack.

The inner portion of a growth ring is formed early in the growing season, when growth is comparatively rapid ( hence the wood is less dense ) and is known as " early wood " or " spring wood " or " late-spring wood ".

Tubular virus particles such as the tobacco mosaic virus ( TMV ) can be used as templates to create nanofibers and nanotubes since both the inner and outer layers of the virus are charged surfaces and can induce nucleation of crystal growth.

The fringing reef becomes a barrier reef for the reason that the outer part of the reef maintains itself near sea level through biotic growth, while the inner part of the reef falls behind, becoming a lagoon because conditions are less favorable for the coral and calcareous algae responsible for most reef growth.

Holloway, like much of inner North London, experienced rapid growth around the very early 1900s and quickly became an important local shopping centre.

Median household income growth slowed, even trailing income growth rates in New Orleans proper, such that the inner city began to narrow the gap in median household income, a gap at its widest at the time of the 1980 Census.

* The third – personal leadership – is an “ inner ” level and concerns a person ’ s growth toward greater leadership presence, knowhow and skill.

Susan ( who initially calls herself Rita ), dissatisfied with the routine of her work and social life, seeks inner growth by signing up for and attending an Open University course in English Literature.

After the Second World War, the population of the County of London and inner Middlesex was in steady decline, with new population growth only experienced in the outer suburbs.

His target was the great importance which the Talmudic view attaches to the fulfillment of a law, while almost entirely disregarding sentiment or the growth of man ’ s inner life.

Each of these parts of the blastocyst gives rise to different parts of the embryo ; the inner cell mass gives rise to the embryo proper, while the trophectoderm and primitive endoderm give rise to extra embryonic structures that support growth of the embryo.

He taught that higher levels of consciousness, higher bodies, inner growth and development are real possibilities that nonetheless require conscious work to achieve.

Tourism in Russia has seen rapid growth since the late Soviet times, first inner tourism and then international tourism as well.

This has caused the town centre and inner city to retain a small-town character, and even after the city's rapid growth in the 1970s onwards, the urbanization of the city center has been limited and a large share of the population still lives in detached houses.

Michael Walzer claimed that the growth of religious toleration in Western nations arose amongst other things, from the general recognition that private conscience signified some inner divine presence regardless of the religious faith professed and from the general respectability, piety, self-limitation, and sectarian discipline which marked most of the men who claimed the rights of conscience.

In 2009 John K. Tucker and Manuel J. Tenorio proposed a classification system for the cone shells and their allies ( which resorb their inner walls during growth ) was based upon a cladistical analysis of anatomical characters including the radular tooth, the morphology ( i. e., shell characters ), as well as an analysis of prior molecular phylogeny studies, all of which were used to construct phylogenetic trees.

There is no exact agreement as to when preadolescence starts and ends, and research suggests that ' chronological time ... is by no means identical with developmental time-the duration of the " inner " stages of growth ' - or with physiological time.

If the prey is unable to escape, it will continue to stimulate the inner surface of the lobes, and this causes a further growth response that forces the edges of the lobes together, eventually sealing the trap hermetically and forming a ' stomach ' in which digestion occurs.

The central spiritual practice which he taught to his disciples was Kriya Yoga, a series of inner pranayama practices that quickly hasten the spiritual growth of the practitioner.

The inner scales enlarge when spring growth begins and often become an inch long before they fall.

: Additional features that are seen in significant numbers of patients with Dravet syndrome may include sensory integration disorders and other autism spectrum characteristics, orthopedic or movement disorders, frequent or chronic upper respiratory and ear infections, sleep disturbance, dysautonomia, and problems with growth and nutrition.

Ear infection-presence and growth of bacteria or viruses in the ear.

One genome-wide association study indicates a possible role for RELN gene variation in otosclerosis, an abnormal growth of bone of the middle ear.

Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in the middle ear and / or mastoid process.

The use of stalls may be preferred as they facilitate feed management and growth control and prevent pig aggression ( e. g., tail biting, ear biting, vulva biting, food stealing ).

Upper respiratory tract infections or allergies can cause the Eustachian tube, or the membranes surrounding its opening to become swollen, trapping fluid, which serves as a growth medium for bacteria, causing ear infections.

Otosclerosis is an abnormal growth of bone near the middle ear.

Cells formed in the centre of the tympanic membrane migrate outwards from the umbo ( at a rate comparable to that of fingernail growth ) to the walls of the ear canal, and move towards the entrance of the ear canal.

It is also known as black fungus, black Chinese fungus ( or mushroom ), wood ear fungus, wood fungus, ear fungus, or tree ear fungus, an allusion to its rubbery ear-shaped growth.

They act by relieving anxiety symptoms and may stimulate new neural growth within the inner ear, allowing more rapid vestibular compensation to occur.

Based on growth rings in their ear bones ( otoliths ), scientists infer that individual coelacanths may live as long as 80 to 100 years.

In cases of Macrotia associated with prominent ears, the child ’ s age might be 2-years, nonetheless, it is advantageous to restrict the further growth of the deformed ear.

* Shaving of one's head and the growth of men's hair beyond the lobe of the ear.

The letters stand for: coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and / or development, genital and / or urinary abnormalities, and ear abnormalities and deafness.