Phalloidin was isolated in 1937 by Feodor Lynen, Heinrich Wieland's student and son-in-law, and Ulrich Wieland of the University of Munich.

Phalloidin, a bicyclic heptapeptide, binds to actin filaments much more tightly than to actin monomers, leading to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments through the prevention of filament depolymerization.

Phalloidin is one of a group of toxins from the death cap ( Amanita phalloides ) known as phallotoxins.

Phalloidin binds F-actin, preventing its depolymerization and poisoning the cell.

Phalloidin binds specifically at the interface between F-actin subunits, locking adjacent subunits together.

Phalloidin functions differently at various concentrations in cells.

It was a war of nerves, of stamina, of dogged endurance in which the stupid insistence of the British on their right to their own country became ultimately an unsurmountable obstacle to the Nazis, who were better organized and technically superior.

There was an air of blindness in her gray eyes, the startled-horse look that ultimately comes to some women who are born at the end of an ancestral line long since divorced from money-making and which, besides, has kept its estate intact.

What ultimately frustrated every challenger was Ruth's amazing September surge.

Even his old literary home, Punch, where the When We Were Very Young verses had first appeared, was ultimately to reject him, as Christopher Milne details in his autobiography The Enchanted Places, although Methuen continued to publish whatever Milne wrote, including the long poem ' The Norman Church ' and an assembly of articles entitled Year In, Year Out ( which Milne likened to a benefit night for the author ).

Paneloux is at pains to emphasize that God did not will the calamity: " He looked on the evil-doing in the town with compassion ; only when there was no other remedy did He turn His face away, in order to force people to face the truth about their life " In Paneloux's view, even the terrible suffering caused by the plague works ultimately for good.

Construction of this machine was never completed ; Babbage had conflicts with his chief engineer, Joseph Clement, and ultimately the British government withdrew its funding for the project.

He is frequently cited as the inventor of the airliner and was awarded several of the first air mail contracts, which he ultimately could not fulfill.

But Leotychidas was ultimately set aside as illegitimate, contemporary rumors representing him as the son of Alcibiades, and Agesilaus became king around 401 BC, at the age of about forty.

By the time of Mesalim, whichever dynasty controlled the city of Kish was recognised as šar kiššati (= king of Kish ), and was considered preeminent in Sumer, possibly because this was where the two rivers approached, and whoever controlled Kish ultimately controlled the irrigation systems of the other cities downstream.

He succeeded his cousin Elagabalus upon the latter's assassination in 222, and was ultimately assassinated himself, marking the epoch event for the Crisis of the Third Century — nearly fifty years of civil wars, foreign invasion, and collapse of the monetary economy.

The outcome was a decision by the 14th International Botanical Congress in 1987 that Amaryllis should be a conserved name ( i. e. correct regardless of priority ) and ultimately based on a specimen of the South African Amaryllis belladonna from the Clifford Herbarium at the British Museum.

It was ultimately decided to target the Apollo 16 mission to the Descartes site.

Alexander Grothendieck was born in Berlin to anarchist parents: a Ukrainian father from an ultimately Hassidic family, Alexander " Sascha " Shapiro aka Tanaroff, and a mother from a German Protestant family, Johanna " Hanka " Grothendieck ; both of his parents had broken away from their early backgrounds in their teens.

The application was ultimately successful.

This was a blow from which the machine never fully recovered, although games sales for it would ultimately outstrip those of the BBC Micro.

Surprisingly, Acts does not record the outcome of Paul's legal troubles — some traditions hold that Paul was ultimately executed in Rome, while other traditions have him surviving the encounter and later traveling to Spain — see Paul-Imprisonment & Death.

By that point, Apple was deep in their ultimately doomed Copland efforts.

" In 2007, Kevin Merida, a coauthor of another book on Thomas, remarked that what happened between Thomas and Hill was " ultimately unknowable " by others, but that it was clear that " one of them lied, period.

Later, however, her daughter-in-law, the Byzantine princess Theophano, turned her husband Otto II against his mother, and she was driven from court in 978 ; she lived partly in Italy, and partly with her brother Conrad, king of Burgundy, by whose mediation she was ultimately reconciled to her son ; in 983 Otto appointed her as his viceroy in Italy.

Phillip's plan was for a squadron of three ships of the line and a frigate to mount a raid on Buenos Aires and Monte Video, then to proceed to the coasts of Chile, Peru and Mexico to maraud, and ultimately to cross the Pacific to join the British Navy's East India squadron for an attack on Manila.

Plant potash lent the name to the element potassium, which was first derived from caustic potash, and also gave potassium its chemical symbol K ( cf German Kalium ), which ultimately derives from alkali.

The purified product was stored at -78-degrees in a tube equipped with a break seal.

Previously purified chlorine was subsequently admitted and the exchange was allowed to take place.

On Feb. 12, 1959, purified corticotropin ( ACTH Gel ), 20 units daily intramuscularly, was started but had to be discontinued 3 weeks later because of excessive fluid retention.

Substance Z, an active urinary peptide, was purified by extraction in organic solvents and repeated column chromatography ; ;

According to Bibliotheca, Alcmene went with Amphitryon to Thebes, where he was purified by Creon for accidentally killing Electryon.

A 22 milligram batch of berkelium-249 was prepared during a 250-day irradiation period and then purified for a further 90 days at Oak Ridge in 2009.

Ben Franklin's mother, Abiah Folger, was born into a Puritan family among those that fled to Massachusetts to establish a purified Congregationalist Christianity in New England, when King Charles I of England began persecuting Puritans.

The home was then purified with holy water to ensure they never came back.

The first DNA ligase was purified and characterized in 1967.

In 1901, Jokichi Takamine patented a purified adrenal extract, and called it " adrenalin ", which was trademarked by Parke, Davis & Co in the U. S. In the belief that Abel's extract was the same as Takamine's, a belief since disputed, epinepherine became the generic name in the U. S. The British Approved Name and European Pharmacopoeia term for this chemical is adrenaline and is indeed now one of the few differences between the INN and BAN systems of names.

Eka-caesium was discovered in 1939 by Marguerite Perey of the Curie Institute in Paris, France when she purified a sample of actinium-227 which had been reported to have a decay energy of 220 keV.

He set times and places for this mourning, and ordered that each family perform such observances within their own private walls, and that the mourning should be complete within a month ; following the completion of these mourning rituals, the entire city was purified of its blood-guilt in the deaths.

The tradition of diglossia, the simultaneous existence of vernacular and archaizing written forms of Greek, was renewed in the modern era in the form of a polarization between two competing varieties: Dimotiki, the vernacular form of Modern Greek proper, and Katharevousa, meaning ' purified ', an imitation of classical Greek, which was developed in the early 19th century and used for literary, juridic, administrative and scientific purposes in the newly formed modern Greek state.

This helium-nitrogen mixture was injected and stored in the Cliffside gas field until needed, when it then was further purified.

Gelatin was sold in sheets and had to be purified, which was very time-consuming.

The fractional crystallization purification of lanthanum as the double ammonium nitrate was sufficiently rapid and efficient, that lanthanum purified in this manner was not expensive.

Morphine was the first active principle purified from a plant source and is one of at least 50 alkaloids of several different types present in opium, poppy straw concentrate, and other poppy derivatives.

The first commercial use of purified neodymium was in glass coloration, starting with experiments by Leo Moser in November 1927.

During this period, the portrayal of opium in literature became squalid and violent, British opium trade was largely supplanted by domestic Chinese production, purified morphine and heroin became widely available for injection, and patent medicines containing opiates reached a peak of popularity.