Significant European settlement began ca.

Significant growth in real estate prices continues, along with other major Romanian cities, as investor sentiment remains high, given the large foreign direct investment influx, recent accession to the European Union and forthcoming airport.

Significant contributors to European exploration include Prince Henry the Navigator of Portugal, who was the first of the Europeans to venture out into the Atlantic Ocean, in 1420.

Significant Macedonian communities can also be found in the traditional immigrant-receiving nations, as well as in Western European countries.

Significant early European settlers included the Chandler family.

Significant investments have included Moneybookers ( now Skrill ), a leading European digital payment company.

However, a group of six dwarves led by Sergei the Significant have already stolen the tiara and plan to sell it at a circus to several European jewellery fences.

Significant new discoveries in European archives were made and published by Steblin ( 2002, 2007, 2009, 2009a ) and Skwara / Steblin ( 2007 ).

Significant opposition to the Iraq War occurred worldwide, both before and during the initial 2003 invasion of Iraq by the United States, United Kingdom, and smaller contingents from other nations, and throughout the subsequent occupation.

Significant amounts of territory were lost: Kentucky had already rejoined the Union in 1916 ; western Texas had been admitted into the Union in 1917 as the state of Houston, with its capital at Lubbock, and Sequoyah was under occupation.

Significant fossil fuel energy resources exist in the Barents Sea region.

Significant fur trapping has continued in the region, but in general the east coast or East Main of James Bay was too easily accessed by French and independent traders from the south so early Hudson's Bay Company emphasis was quickly placed onto interior trapping grounds reached from the west coasts of James and Hudson Bays.

Significant remaining forested areas are in the Gascony region and north in the Alsace-Ardennes area.

Significant irrigation supports the growing of wolfberries, a commonly consumed fruit throughout the region.

Significant quantities of gold were discovered in Johannesburg in 1886, setting off another mass migration as speculators, prospectors, fortune-seekers, and adventurers from all over the world descended upon the region.

Significant immigrants such as Arabs from the west since the 7th century and Turkic peoples after the Turkic migration from the north in the Middle Ages settled in the region.

Significant populations of Khmers reside in adjacent areas of Thailand ( Northern Khmer ) and the Mekong Delta region of neighboring Vietnam ( Khmer Krom ).

Significant copper deposits were found in the vicinity of Windy Craggy Mountain, in the middle of the Tatshenshini region.

Significant differences in political views between unionists, nationalists and republicans are reflected in the variations of names they use for the region.

Significant hairstyle trends of the 1980s include the Perm ( started popularity in the late 1970s ), the Mullet ( evolved from the 1970s to a cleaner look using hair gel ), the Jheri curl, the Flattop, the Hi-top fade and Big hair.

Significant safety efforts were instituted started in 1999.

Significant are such canvases as `` Bleeker Street, Saturday Night '', with its typically American crowd ( Sloan never went abroad ) ; ;

Significant alcohol intake produces changes in the brain's structure and chemistry, though some alterations occur with minimal use of alcohol over a short term period, such as tolerance and physical dependence.

Significant changes came in 1910 with the reform of the Roman Breviary by Pope Pius X.

Significant trade with neighbouring countries, for example, exports of camels and other livestock to neighbouring states, such as Libya, and imports of manufactured goods, are conducted " informally " and probably not fully recorded.

Significant tunnel and bridge construction projects in the south of Dalmatia are planned, such as the Biokovo tunnel near Makarska, which will connect the panoramic seashore road with the future A1, and a long Pelješac bridge, connecting the Pelješac peninsula to the Croatian mainland.

" Significant amounts " of hexavalent chromium were found in the water of more than 40 homes in the area, some of which have now been fitted with state-monitored filters on their water supply.

* African festivals Significant African festivals based on the continent include the biannual Panafrican Film and Television Festival of Ouagadougou FESPACO in Burkina Faso, the annual Durban International Film Festival which has grown in importance for industry with the addition of a co-production forum and Talent Campus.

Significant failure of monsoon rains historically meant drought and famine while above-normal rains still cause flooding and landslides with losses in human lives, farmland and buildings.

Significant progress has also been made in bringing the world of UML modeling and the Semantic Web together through the adoption of the Ontology Definition Metamodel which relates UML models in a standard way with RDF and Web Ontology Language ( OWL ) models.

Significant contributions to oceanographic knowledge were made by the voyages of HMS Beagle in the 1830s, with Charles Darwin aboard ; HMS Challenger during the 1870s ; the USS Tuscarora ( 1873 – 76 ); and the German Gazelle ( 1874 – 76 ).

Significant privatizations of this nature occurred from 1760 to 1820, coincident with the industrial revolution in that country.

Significant privatization of state owned enterprises in Eastern and Central Europe and the former Soviet Union was undertaken in the 1990s with assistance from the World Bank, the U. S. Agency for International Development, the German Treuhand, and other governmental and nongovernmental organizations.

Significant advances in the state-of-the-art in CSR have been achieved, and current efforts are focused on integrating speech recognition and natural language processing to allow spoken language interaction with a naval resource management system.

Significant differences remain with Myanmar over boundary alignment and the handling of ethnic rebels, refugees and illegal drug trade, in addition to mineral exploration and fishing rights.

The Fermi-1 commercial fast reactor prototype used HEU with 26. 5 % < sup > 235 </ sup > U. Significant quantities of HEU are used in the production of medical isotopes, for example molybdenum-99 for technetium-99m generators.

Significant problems with the metric of this form stem from the fact that all known warp drive spacetimes violate various energy conditions.

These " Bloomsbury assumptions " are also reflected in members ' criticisms of materialistic realism in painting and fiction, influenced above all by Clive Bell's " concept of ' Significant Form ', which separated and elevated the concept of form above content in works of art ": it has been suggested that, with their " focus on form ... Bell's ideas have come to stand in for, perhaps too much so, the aesthetic principles of the Bloomsbury Group ".

Significant progress came following the work of Louis Pasteur and his advances in microbiology, when the British surgeon Joseph Lister began experimenting with using phenol during surgery to prevent infections.

Significant contact with Tatars and Turks resulted in many Turkic words, particularly those involving military matters and steppe industry, being adopted into the Ukrainian language.

Significant amounts of teaching occurred in the museum as well with students claiming they learnt far more in the museum than they ever did in the lecture theatre.

Significant emphasis was also placed on town planning, with new conservation areas introduced and a new generation of new towns built, notably Milton Keynes – this trend itself a continuation of efforts initiated in the latter years of the preceding Conservative administration.

Significant numbers of British Churchill and Matilda tanks along with US M3 Lee were shipped to the USSR after becoming obsolete on the African Front with the Churchills supplied by the arctic convoys seeing action around Leningrad while tanks shipped by the Persian route supplied the Caucasian Front.

Significant events of the latter variety occurred in Colorado and Kansas in May 2004 with winds to 100 mph ( 161 km / h ), Minnesota and Wisconsin in June 2004 causing significant damage, and the upper Middle West in May 1988, notable for strong electrification and lightning activity and by one estimate reaching 30, 000 ft ( 9, 144 m ) or more.