Significant alcohol intake produces changes in the brain's structure and chemistry, though some alterations occur with minimal use of alcohol over a short term period, such as tolerance and physical dependence.

Significant syntactic changes have arisen in Modern Hebrew as a result of non-Semitic substrate influences.

" Significant changes happened in the British Poor Law system in England and Wales, Scotland, and Ireland.

Significant changes occurred in the economy of the Tennessee Valley and the nation, prompted by an international oil embargo in 1973 and accelerating fuel costs later in the decade.

Significant crops in montane forest zones include tea and coffee, and the logging of unique species causes changes to the forest structure.

Significant changes in the number of fixed and mobile services deployed in Bangladesh occurred in the late 1990s and the number of services in operation have subsequently grown exponentially in the past five years.

Significant changes to the cathedral were made by the architect James Wyatt in 1790, including replacement of the original rood screen and demolition of the bell tower which stood about 320 feet ( 100 m ) north west of the main building.

Significant changes in its management and language were brought in 1515 by Mahmoud Pasha Elekhani.

Significant changes were made to the program as Ross asserted her influence.

Significant organisational changes to the base occurred as a result of the post-Cold War reorganization of the USAF.

Significant changes have occurred since the largest private shareholder, Alcatel, sold its stake in Thales to Dassault.

Significant changes are the improvement of the rear sight form transitioning from a V-notch type like those on a Type 38, to an aperture, the front sight blade was renewed to a triangular shape, chrome-lined barrels were used, and on earlier productions, the rear sight was equipped with anti-aircraft calipers.

Significant changes introduced into the 1968 document included Article 6, which committed the state to adhere to the " principles of socialist internationalism " and to devote special attention to its " fraternal ties " with the Soviet Union ; Article 9, which based the national economy on the " socialist ownership of the means of production "; Article 20, which under pressure from the churches granted freedom of conscience and belief ; Article 21, which maintained that the " basic rights " of citizenship were inseparably linked with " corresponding obligations "; and Article 47, which declared that the principle of " democratic centralism " is the authoritative maxim for the construction of the socialist state.

Significant changes in the language and management of the province were brought in 1515 by Mahmoud Pasha Elekhani.

Significant changes in pressure during the procedure can indicate tumors or spinal blockage resulting in a large pool of CSF, or hydrocephalus associated with large volumes of CSF.

Significant changes for the album Ageless Decay are the artwork by Dimitar Nikolov and the mixing and mastering by Tommy Hansen.

Significant changes were made to Dr. Loveless ( played by Kenneth Branagh in the film ).

Significant powertrain changes were made for 1986.

Significant hypercalcaemia can cause ECG changes mimicking an acute myocardial infarction.

Significant changes enacted at the national levels included the imposition of an income tax with the Sixteenth Amendment, direct election of Senators with the Seventeenth Amendment, Prohibition with the Eighteenth Amendment, and women's suffrage through the Nineteenth Amendment to the U. S. Constitution.

Significant changes under autonomy are the setting up of Distance Education Programmes ( DEP ) with IIT Bombay, with VJTI being a Remote Centre ; as also the modernization of the Library to a digital library.

Significant changes to the game's ending were made late in development following the September 11 attacks in New York, where the finale occurs.

Significant changes in cays and their surrounding ecosystems can result from natural phenomena such as severe El Niño Southern Oscillation ( ENSO ) cycles.

Significant changes in the Leaving Certificate maths curriculum were reflected in two new textbooks produced by the Irish Christian Brothers.

Significant progress came following the work of Louis Pasteur and his advances in microbiology, when the British surgeon Joseph Lister began experimenting with using phenol during surgery to prevent infections.

Significant protection was still part of the plan as the reduction primarily came on those imports not in competition with domestic producers.

Significant Clovis finds include the Anzick site in Montana ; the Blackwater Draw type site in New Mexico ; the Colby site in Wyoming ; the Gault site in Texas ; the Simon site in Idaho ; the East Wenatchee Clovis Site in Washington ; and the Fenn cache, which came to light in private hands in 1989 and whose place of discovery is unknown.

Significant growth came in the mid-sixties after the firm signed Mobil Oil and the available budgets grew materially.

Significant settlement at Cwmcarn came with Bronze Age migration of local tribes from the Gwent levels to the uplands of Mynydd y Grug, Mynydd Machen and Mynydd Maen ( Twmbarlwm ) and led to a later Iron Age ( 900 – 55 BC ) hillfort to be constructed by the Silures on Twmbarlwm.

Significant initial support came from U. S. Senators Charles McC.

Most notable among Mead's published papers are “ Suggestions Towards a Theory of the Philosophical Disciplines ” ( 1900 ); “ Social Consciousness and the Consciousness of Meaning ” ( 1910 ); “ What Social Objects Must Psychology Presuppose ” ( 1910 ); “ The Mechanism of Social Consciousness ” ( 1912 ); “ The Social Self ” ( 1913 ); “ Scientific Method and the Individual Thinker ”( 1917 ); “ A Behavioristic Account of the Significant Symbol ” ( 1922 ); “ The Genesis of Self and Social Control ” ( 1925 ); “ The Objective Reality of Perspectives ” ( 1926 );” The Nature of the Past ” ( 1929 ); and “ The Philosophies of Royce, James, and Dewey in Their American Setting ” ( 1929 ).

Significant are such canvases as `` Bleeker Street, Saturday Night '', with its typically American crowd ( Sloan never went abroad ) ; ;

Significant trade with neighbouring countries, for example, exports of camels and other livestock to neighbouring states, such as Libya, and imports of manufactured goods, are conducted " informally " and probably not fully recorded.

Significant tunnel and bridge construction projects in the south of Dalmatia are planned, such as the Biokovo tunnel near Makarska, which will connect the panoramic seashore road with the future A1, and a long Pelješac bridge, connecting the Pelješac peninsula to the Croatian mainland.

" Significant amounts " of hexavalent chromium were found in the water of more than 40 homes in the area, some of which have now been fitted with state-monitored filters on their water supply.

* African festivals Significant African festivals based on the continent include the biannual Panafrican Film and Television Festival of Ouagadougou FESPACO in Burkina Faso, the annual Durban International Film Festival which has grown in importance for industry with the addition of a co-production forum and Talent Campus.

Significant failure of monsoon rains historically meant drought and famine while above-normal rains still cause flooding and landslides with losses in human lives, farmland and buildings.

Significant progress has also been made in bringing the world of UML modeling and the Semantic Web together through the adoption of the Ontology Definition Metamodel which relates UML models in a standard way with RDF and Web Ontology Language ( OWL ) models.

Significant contributions to oceanographic knowledge were made by the voyages of HMS Beagle in the 1830s, with Charles Darwin aboard ; HMS Challenger during the 1870s ; the USS Tuscarora ( 1873 – 76 ); and the German Gazelle ( 1874 – 76 ).

Significant privatizations of this nature occurred from 1760 to 1820, coincident with the industrial revolution in that country.

Significant privatization of state owned enterprises in Eastern and Central Europe and the former Soviet Union was undertaken in the 1990s with assistance from the World Bank, the U. S. Agency for International Development, the German Treuhand, and other governmental and nongovernmental organizations.

Significant advances in the state-of-the-art in CSR have been achieved, and current efforts are focused on integrating speech recognition and natural language processing to allow spoken language interaction with a naval resource management system.

Significant differences remain with Myanmar over boundary alignment and the handling of ethnic rebels, refugees and illegal drug trade, in addition to mineral exploration and fishing rights.

The Fermi-1 commercial fast reactor prototype used HEU with 26. 5 % < sup > 235 </ sup > U. Significant quantities of HEU are used in the production of medical isotopes, for example molybdenum-99 for technetium-99m generators.

Significant problems with the metric of this form stem from the fact that all known warp drive spacetimes violate various energy conditions.

These " Bloomsbury assumptions " are also reflected in members ' criticisms of materialistic realism in painting and fiction, influenced above all by Clive Bell's " concept of ' Significant Form ', which separated and elevated the concept of form above content in works of art ": it has been suggested that, with their " focus on form ... Bell's ideas have come to stand in for, perhaps too much so, the aesthetic principles of the Bloomsbury Group ".

Significant contact with Tatars and Turks resulted in many Turkic words, particularly those involving military matters and steppe industry, being adopted into the Ukrainian language.

Significant amounts of teaching occurred in the museum as well with students claiming they learnt far more in the museum than they ever did in the lecture theatre.

Significant emphasis was also placed on town planning, with new conservation areas introduced and a new generation of new towns built, notably Milton Keynes – this trend itself a continuation of efforts initiated in the latter years of the preceding Conservative administration.

Significant numbers of British Churchill and Matilda tanks along with US M3 Lee were shipped to the USSR after becoming obsolete on the African Front with the Churchills supplied by the arctic convoys seeing action around Leningrad while tanks shipped by the Persian route supplied the Caucasian Front.

Significant events of the latter variety occurred in Colorado and Kansas in May 2004 with winds to 100 mph ( 161 km / h ), Minnesota and Wisconsin in June 2004 causing significant damage, and the upper Middle West in May 1988, notable for strong electrification and lightning activity and by one estimate reaching 30, 000 ft ( 9, 144 m ) or more.

Significant growth in real estate prices continues, along with other major Romanian cities, as investor sentiment remains high, given the large foreign direct investment influx, recent accession to the European Union and forthcoming airport.