The Fermi-1 commercial fast reactor prototype used HEU with 26. 5 % < sup > 235 </ sup > U. Significant quantities of HEU are used in the production of medical isotopes, for example molybdenum-99 for technetium-99m generators.

Significant shows at regional galleries included a survey of contemporary outsider art at Orange Regional Gallery, and a survey of the important commercial Gallery A and Anne Judell at Campbelltown Regional Gallery, Lawrence Daws at Caloundra Regional Art Gallery and the Janet Dawson survey at Bathurst Regional Gallery.

Significant Other saw Limp Bizkit reaching a new level of commercial success.

Significant commercial and retail centres on the North Shore include North Sydney, Crows Nest, Chatswood, St Leonards, Neutral Bay and Gordon.

Significant commercial buildings include Alston's Corner ( 1914 ) by Nahum Barnet is an excellent surviving example of Edwardian architecture, while the Block Arcade by D. C Askew ( 1893 ) is an excellent example of high Victorian mannerist architecture.

Significant populations occur in pockets in the waters off the Pribilof and Shumagin Islands, Shelikof Strait, Prince William Sound and at least as far south as lower Chatham Strait in the south-east, where a regular commercial fishery occurs annually.

Significant commercial activity has developed along 400 South, especially directly north of Trolley Square.

Significant commercial hurdles, culminating in hearings at an International Arbitration Tribunal seated in Lisbon, in 1988, also had to be overcome.

Significant European occupation in this region started with the Central Otago Gold Rush in the 1860s, but a French immigrant gold miner, Jean Desire Feraud, soon started planting vines and embarking upon small-scale commercial wine production — even winning medals in Australian wine competitions.

Significant commercial markets have been developed for its application in textile and industrial fibers, films, and foamed articles, containers for carbonated beverages, water and other liquids, and thermoformed applications.

Significant factors in the development of armour include the economic and technological necessities of armour production.

Significant events in the early development of rugby football were the production of the first set of written football laws at Rugby School in 1845, which was followed by the ' Cambridge Rules ' drawn up in 1848.

Significant research has been undertaken into the development of novel wine yeast strains that produce atypical flavour profiles or increased complexity in wines.

Significant contributions to the war effort included the development in 1940 of the cavity magnetron for radar, by the scientists John Randall and Harry Boot, at the University of Birmingham, and advances in communications technology and the ongoing mass production of valves, lamps and lighting equipment.

Significant development occurred after the coming of the Chesapeake and Ohio Railroad and George D. Winn's ferry to Portsmouth, Ohio in the 1890s.

Significant portions of the eastern quarter of the township are designated by the Pinelands Commission as part of the Regional Growth Area ( RGA ), in which development is " allowed and encouraged " in the area surrounding Atlantic City, New Jersey.

Significant investment of time is essential for materials development and creating an atmosphere conducive to self-study.

Significant to the early development of SOF magazine was its unprecedented, successful recruitment of foreign nationals to serve in the Rhodesian Security Forces, during the Rhodesian Bush War ( 1964 – 79 ).

Significant to the village's development is the existence of London Oxford Airport.

Significant changes to the game's ending were made late in development following the September 11 attacks in New York, where the finale occurs.

Significant development of the area commenced in the 1970s, with development continuing through to the present.

Significant residential development occurred during the 1960s and 1970s, spurred by industrial growth and public housing construction.

Significant parts of the Samos development program were Samos-E ( visual reconnaissance ), Samos-F ( ELINT Ferret reconnaissance ), and Samos-H ( communications ).

Significant compression of hydrogen gas occurs that leads to the development of starbirth regions.

Significant development did not occur until the post-war years, with rapid growth from the 1950s into the 1970s.

Significant investment ( over £ 170 million ) is taking place at Pirbright with the development of new world class laboratory and animal facilities.

Significant development took place from the early 20th century into the 1950s, spurred by improved access.

Significant factors in the development of armor include the economic and technological necessities of armor production.

Significant development of Pascoe Vale South took place after the tram was extended to Bell Street in 1927, with the post office opening on 1 August 1927.

Significant development occurred in Hadfield after World War II, with the Hadfield Post Office opening on 6 May 1957.

Significant development of the school that began in the late 1920s, when land acquisitions provided dormitory accommodation and facilities for the growing school, continued in during the next three decades.

The city government of San Francisco mandated the development of management plans for all the " natural areas " under the city's control, and this process culminated in release of the Significant Natural Resources Areas Management Plan in February 2006.

Significant subsequent improvements and modifications to microprobes included scanning the electron beam to make X-ray maps ( 1960 ), the addition of solid state EDS detectors ( 1968 ) and the development of synthetic multilayer diffracting crystals for analysis of light elements ( 1984 ).

Significant regional differences in legislation, financing, support agencies and corporate structures can be seen across Canada as a result of different historical development paths in the social economy.

Significant progress came following the work of Louis Pasteur and his advances in microbiology, when the British surgeon Joseph Lister began experimenting with using phenol during surgery to prevent infections.

Significant European settlement began ca.

Significant growth in the area, aided its proximity to Abilene, began to occur in the late 1980s and by 1992 there were 1, 441 people living in Potosi.

Significant settlement began in the late 1810s.

Significant developments to the little city airport began only after the city built hangars and administrative facilities for the Army and Navy in 1928-30.

Significant human impacts on the area began in the 16th century.

Significant numbers of more affluent Indian residents began relocating out of Laudium, to newly established nearby security estates in Centurion in the late 2000s.

* 1993: Old aquarium was closed and construction of the new aquarium began, Zoo received two AAZPA awards: the Conservation Award for its black-footed ferret management program and the Significant Achievement Award for the Lied Jungle, world ’ s first artificially-inseminated gaur calf was born at the Zoo

Significant riots began to occur on Chicago's West Side starting in 1965, and an especially damaging riot in 1968 ( after Martin Luther King's death ) prompted many white residents to leave.

Significant investment began in earnest in the wake of the Louisiana Purchase of 1803, as people from other parts of the United States flocked to the city.

Significant suburban residential development began with the opening of the Montrose subdivision in 1913, accelerating significantly after World War II.

Significant demographic shifts in the island population began in 1962 when the French financed, Mauritian Company, Societe Huiliere de Diego et Peros, which had consolidated ownership of all the plantations in the Chagos in 1883, sold the plantations to the Seychelles Company, Chagos-Agalega Company, which then owned the entire Chagos Archipelago, except for six acres at the mouth of the Diego Garcia lagoon.