Since many of the genes are also implicated in other autoimmune diseases, including rheumatoid arthritis and type 1 diabetes -- and treatments have already been developed that target these genes -- this discovery may soon lead to new treatments for the 5. 3 million Americans suffering from hair loss caused by alopecia areata.

Since the 1990s, independent, comprehensive reviews of the studies seeking causal links between silicone-gel breast implants and systemic disease reported no causal link between the implants and subsequent systemic and autoimmune diseases.

Since 1977, Harris has suffered from a chronic autoimmune disorder, diagnosed as a combination of lupus and systemic sclerosis.

Since German was the lingua franca of science ( and especially of psychiatry ) at that time, Kraepelin's use of Alzheimer's disease in a textbook made the name famous.

Since the late 1980s, evidence has become available that instillation of BCG into the bladder is an effective form of immunotherapy in this disease.

Since the 1990s to the present, responses to mad-cow disease, genetically modified foods, flu epidemics in pigs and birds, and an increase in foodborne illness outbreaks, agricultural pollution, and Concentrated Animal Feeding Operations ( CAFOs ) have led people to question where their food comes from and what is actually in it.

Since then, many effective antimalarials have been introduced, although quinine is still used to treat the disease in certain critical circumstances, such as severe malaria, and in impoverished regions due to its low cost.

Since the late 1990s, devil facial tumour disease has drastically reduced the devil population and now threatens the survival of the species, which in 2008 was declared to be endangered.

Since the 17th century, several major epidemics of the disease have been recorded in the Americas, Africa, and Europe.

Since the 1980s, the number of cases of yellow fever has been increasing, making it a re-emerging disease.

Since the Ca < sup > 2 +</ sup > hypothesis of Alzheimer ’ s was proposed in 1994, several studies have shown that disruptions in Ca < sup > 2 +</ sup > signalling are the primary cause of Alzheimer ’ s disease.

Since all plants in a monoculture are genetically similar, if a disease strikes to which they have no resistance, it can destroy entire populations of crops.

Since the dangers of the disease are well known, while the dangers of the vaccine are quite minimal, most doctors recommend vaccination.

Since chemotherapy on its own is not guaranteed to completely rid the patient of disease, patients are often kept on the drugs for extended periods of times ( i. e. more than 6 months, years ).

Since circa 1990 however, the elm has enjoyed a renaissance through the successful development in North America and Europe of cultivars highly resistant to the new disease.

* Since cybersex can satisfy some sexual desires without the risk of a sexually transmitted disease ( STD ) or pregnancy, it is a physically safe way for young people ( such as with teenagers ) to experiment with sexual thoughts and emotions.

Since this disease is not well known and often remains undiagnosed, mortality might be much higher.

Since the disease disproportionately targets children a majority of the honorees were youth soccer players.

Since the distribution of the defective mitochondrial DNA may vary from organ to organ within the body, and each mutation is modulated by other genome variants, the mutation that in one individual may cause liver disease might in another person cause a brain disorder.

Since the end of the 20th century, medical anthropologists have had a much more sophisticated understanding of the problem of cultural representations and social practices related to health, disease and medical care and attention.

Since the start of the 20th century, research on keratoconus has both improved understanding of the disease and greatly expanded the range of treatment options.

Since 1990, Agutter has brought up her son and her work has been in sound recordings and supporting charities, notably the Cystic Fibrosis Trust, of which she is a patron ( she is also a carrier of the disease ).

Since the Europe outbreak of ' mad cow disease ' or ( bovine spongiform encephalopathy ) in 2000, tallow is replaced for many uses by vegetable oleic fatty acids, such as palm kernel and coconut oils.

Since it is unknown whether chronic wasting disease ( CWD ), a transmissible spongiform encephalopathy among deer ( similar to mad cow disease ), can pass from deer to humans through the consumption of venison, there have been some fears of contamination of the food supply.

An audience member at a lecture by Georgi Morozov on forensic psychiatry in the Serbsky Institute asked, “ Tell us, Georgi Vasilevich, what is actually the diagnosis of sluggish schizophrenia ?” Since the question was asked ironically Morozov replied ironically: “ You know, dear colleagues, this is a very peculiar disease.

Since detectable antibody responses require about a week after infection to develop, serologic testing may be falsely negative early in the disease course.

Since the complicated process of establishing new communes and reviewing the rudimentary plan left by the French did not even begin until the fall of 1957, this goal appears somewhat ambitious.

Since effective area coverage appears fairly remote, the requirement can be borne in mind while considering the elements: air, surface, sub-surface, fixed installations, mines, and intelligence.

Since the 1980s, the baku appears not as a chimera of an elephant and tiger but as a zoologically recognizable tapir.

Since Arafat's death, he is formally head of Fatah's political bureau and chairman, but his actual political following within Fatah appears limited.

Since the winding resistance appears as a resistance in series with the inductor, it is often called the series resistance.

Since most wiki systems use URLs for individual pages where the page's title appears at the end of an otherwise unchanging address, the simplest way of defining such mappings is by substituting the interwiki prefix for the unchanging part of the URL.

Since the Laplace operator appears in the heat equation, one physical interpretation of this problem is as follows: fix the temperature on the boundary of the domain according to the given specification of the boundary condition.

Since then, Lucia di Lammermoor has remained a staple of the standard operatic repertoire, and appears as number nineteen on the Operabase list of the most-performed operas worldwide.

Since the earliest days of Esperanto, the colour green has been used as a symbol of mutual recognition and it appears prominently in all Esperanto symbols.

Since our planet rotates, it appears to a stationary observer on Earth that a gyroscope's axis is completing a full rotation once every 24 hours.

Since neither the Congress nor the President appears to have authorized a privateer during the war, the Navy would not have had the authority to do so by itself.

Since the Simpson family frequently appears in court, other characters have represented the Simpsons in legal matters since Hutz's retirement.

Since their introduction, Koopa Troopas have become the iconic enemy of the Mario franchise, often referenced in popular culture relating to the series: in 2007's The Simpsons Game, a Koopa Troopa appears as the apparent bride of the eccentric geek Professor Frink after Bart and Lisa rescue him from Donkey Kong in a parody of the popular arcade game.

Since porphyrins are not otherwise present in skin, and no UV light is employed, it appears to be safe, and has been cleared for marketing by the U. S. FDA.

Since Etruscan literature has not survived, the meaning of the scenes in which he appears can only be interpreted by comparison to Greek and Roman myths, through information about Etruscan myths preserved by Greek and Latin literature, or through conjectural reconstructions based on other Etruscan representations.

In 2008 the club celebrated what was claimed to be the 150th anniversary of the first meeting of its founding members, published " Melbourne FC – Since 1858 – An Illustrated History " and commemorated its formation by naming " 150 Heroes " as well as a birthday logo which appears on its official jersey.

Since the Second Vatican Council ( 1962 – 65 ), the liturgy for the conferral of the pallium as it appears in the liturgical books is to take place at the beginning of the Mass in which the archbishop takes possession of his see ; however, the practice of Pope John Paul II and Pope Benedict XVI has actually been to summon all new metropolitans to Rome to receive the pallium directly from the hands of the pope on the Feast of Saints Peter and Paul.

Since the mid 1990s, Billie Godfrey has worked with the band as a backing vocalist and appears with them at concerts.

Since BFS appears to cause no actual nerve damage ( at least as seen on the EMG ), patients will likely exhibit a completely normal EMG ( or one where the only abnormality seen is fasciculations ).

Since no one intervenes during the incident, such behaviour appears to have been expected of him.

Since Mrs. Voorhees, the killer in the original Friday the 13th, appears onscreen only during the final scenes of the film, Manfredini had the job of creating a score that would represent the killer in her absence.

Since it appears that Shūzō's mother, Hatsu, was already pregnant when she fell in love with Okakura Kakuzō ( 岡倉 覚三 ), otherwise known as Okakura Tenshin ( 岡倉 天心 ), a protégé of her husband's ( a notable patron of the arts ), the rumour that Okakura was Kuki's father would appear to be groundless.

Since Julia appears on the South Frieze, it is more likely that this figure is Octavia Minor.

Since her retirement from politics, she appears infrequently at space-related events, and appears to be content with being out of the limelight.