He and the Blob tracked down the X-Men, and they fought the united forces of Spider-Man and the original X-Men.

After he stole a formula that Spider-Man needed to cure his Aunt May, Spider-Man tracked Octopus ' gang to their base.

Spider-Man and the Human Torch eventually tracked down his base, save the captive J. Jonah Jameson Sr. ( May's fiancee ), Carlie Cooper, and Norah Winters, and finally destroyed Doctor Octopus ' hold over the city.

King tracked Garth to New York where he was assisted by Spider-Man in rescuing Garth from Lilith, the daughter of Dracula.

After being confined in an asylum, Alistair released himself and took several other inmates with him in order to construct a new series of spider-slayers that tracked Spider-Man across the city.

His crowning achievement of evil was the near-fatal beating of Spider-Man's then-partner, the Black Cat, which led to Spider-Man beating Doc Ock to within an inch of his life.

During a prolonged battle with Octavius and Spider-Man, Carlyle was defeated when Doc Ock ripped open his suit, allowing Spider-Man to fill Carlyle's suit with webbing, although Doc Ock informed his enemy that he only did this to hurt Carlyle rather than to help Spider-Man.

In Spider-Man: India, Dr. Octopus is featured as a minion / meek doctor who is transformed by Nalin Oberoi into a mystical version of Doc Ock.

* Doc Ock is one of the bosses in The Amazing Spider-Man for the Game Boy.

In the next level, Doc Ock pulls a heist on the bank, like he did in the movie and the main console version, and after Spider-Man defeats several of Ock's crooks and saves several security guards and civilians, he confronts Ock in the bank's basement.

* Doc Ock has been recreated in action figure form multiple times, first as part of Mattel's Secret Wars line, then later many times by Toy Biz in their Spider-Man and Marvel Legends series, and finally by Hasbro as part of their Spider-Man: Origin series.

The character reappears as a memory in the mind of the Hulk ; battles Doc Samson and Spider-Man ; and again as an illusion by the entity Glorian.

In " Group Therapy ", he escapes from Ryker's Island with Doc Ock, Shocker, Fancy Dan and Ox, Sandman, Vulture and Electro ; all the villains team up to take down Spider-Man as ( the Daily Bugle dubs them ) the Sinister Six, where he rekindles his partnership with Flint Marko, who has now become Sandman.

The final release to feature this was the DVD edition of Spider-Man vs. Doc Ock in 2004.

The first 3 ( X-Men vs. the Brotherhood, Spider-Man vs. Doc Ock, and Batman vs. the Joker ) drew all their cards from other expansion sets.

Spider-Man 2 movie poster of Doc Ock

And just before he is defeated, Rhino charges at Spider-Man one last time, escapes the laser field but accidentally rams into a gas station that blows up and knocks him several blocks away from the explosion, where Doc Ock takes his unconscious form.

There, Puma finally surrenders in his fight against Spider-Man, but gleefully tells him that he was merely a distraction for Spider-Man while Doc Ock kidnapped Mary Jane.

Then Spider-Man leaves OsCorp through an elevator to continue his search for Doc Ock on OsCorp's rooftop before he finds himself in a New York literally torn out of the ground and into the sky by the machinations of the supervillain Mysterio, who has done this to further Ock's plans.

Spider-Man takes the final fight to Doc Ock through the subways, fighting past the remainder of Ock's cronies, saving Mary Jane and battling Doc Ock in a final showdown at his fusion reactor.

* Director of the Spider-Man films, Sam Raimi, has stated that Ock was intended to appear in the first film, teaming up with Green Goblin, but wasn't included because Raimi thought it " wouldn't do the movie justice to have a third origin in there.

Ock robs the first national bank of Manhattan, but is interrupted by Spider-Man.

After a skirmish with the somewhat-debilitated Spider-Man, Ock abandons the bank heist and abducts Aunt May for use as a hostage.

Spider-Man wins the day, but Ock avoids capture.

Ock easily captures the now exhausted Spider-Man after he saves the speeding train.

There, Ock is stealing much gold and money in a vault and after Spider-Man solves a puzzle that opens the large triple door that is separating them, they battle.

Ock escapes, and Spider-Man is forced to let him go to save his Aunt May from three crooks who have decided to kidnap her and place her in their van.

Later, after Spider-Man defeats the supervillain Puma at a construction site, Puma reveals to Spider-Man he was merely a distraction for Spider-Man while Ock kidnapped his girlfriend, Mary Jane Watson, which Ock did.

Spider-Man took care of all those, but Ock counted on Mysterio to distract the vigilante with an illusion of New York literally torn up out of the ground.

In early 1963, with the success of Spider-Man in Amazing Fantasy, The Incredible Hulk, The Mighty Thor, Iron Man, and The Fantastic Four, creator Stan Lee devised the series title after Marvel publisher Martin Goodman turned down the initial name, " The Mutants ", stating that readers would not know what a " mutant " was.

He is also a supporting character in the Ultimate Spider-Man episode " Field Trip ", where he forges magical weapons for Spider-Man's team to take down Loki in support of Thor.

The following issue, when Peter took Aunt May and Mary Jane to a sleazy motel for refuge, a prostitute witnessed Peter check into his room, and now knowing that Peter is Spider-Man, called up a crime organizer named ' Lucille ' and put Peter's name down as a hit.

Following an attack on Peter by Puma, she breaks down and admits her knowledge of Peter's secret identity in The Amazing Spider-Man vol.

During the events of the 2006-2007 " Civil War " storyline, when Peter and Mary Jane's apartment and Aunt May's house are burned down by Charlie Weiderman, and Spider-Man joins the New Avengers, Mary Jane and Aunt May accompany him to live in Stark Tower.

Despite his violent actions and dark nature, the Punisher has enjoyed some mainstream success ( although toned down ) on television, making guest appearances on Spider-Man: The Animated Series and even The Super Hero Squad Show.

* Vladimir Kravinoff took up the name " Grim Hunter " and decided to hunt down Spider-Man and several of his foes.

In the TV show, he hunts down dangerous animals, and intends to hunt and kill Spider-Man on live television in order to boost his ratings.

" His hunt is initially interrupted by Punisher who intends to kill Spider-Man, but the two eventually work together to track down Spider-Man and restore him to his human form with Dr. Crawford's help.

He became May Parker's tenant, then got close enough to use the Nullifier on Spider-Man ; although he had hoped that it would merely nullify Spider-Man's web-shooters, the radiation in Spider-Man's blood resulted in the Nullifier's interaction with Spider-Man's unique biology rendering him amnesiac, Doctor Octopus subsequently tricking Spider-Man into helping him before Spider-Man's own better nature resulted in him turning against his ' partner ' despite his memory loss long enough for John Jameson to use the Nullifier to shut down his tentacles.

Spider-Man was forced to let his nemesis beat him in combat so as to allow Octavius to break free of his fears and recruit him to save New York City from an exploding nuclear reactor ; Octavius had been planning to detonate the reactor to kill Spider-Man indirectly, but after his out-of-control arms beat Spider-Man seemingly senseless, Spider-Man convinced him to shut down the reactor to ensure that there were witnesses to his ' great triumph '.

Doctor Octopus talks with Chameleon stating that he had placed an Octo-Tracker on Spider-Man in order to track him down.

Norman Osborn then contacts Doctor Octopus stating to take down Spider-Man or he will terminate him.

The tentacle part of Doctor Octopus breaks free and tries to attack them until Spider-Man and Iron Man took the tentacle part down.

Once Spider-Man finally defeats Ock, he realizes the error of his ways like he did in the movie, and sacrifices himself by pulling his machine down into the river as Spider-Man saves Mary Jane.