* Substance P is an undecapeptide responsible for transmission of pain from certain sensory neurons to the central nervous system.

* Substance P

Examples of such transmitters include non-peptides: ATP, GABA, dopamine, NO, and peptides: neuropeptide Y, VIP, GnRH, Substance P and CGRP.

* Substance P antagonist, a term used in biochemistry

* Substance P, a neuropeptide

Substance P and its closely related neuropeptide neurokinin A ( NKA ) are produced from a polyprotein precursor after differential splicing of the preprotachykinin A gene.

Substance P is released from the terminals of specific sensory nerves, it is found in the brain and spinal cord, and is associated with inflammatory processes and pain.

Substance P and the NK1 receptor are widely distributed in the brain and are specifically found in brain regions that regulate emotion ( hypothalamus, amygdala, and the periaqueductal gray ).

Substance P is an important element in pain perception.

Substance P coexists with the excitatory neurotransmitter glutamate in primary afferents that respond to painful stimulation.

Substance P has been associated with the regulation of mood disorders, anxiety, stress, reinforcement, neurogenesis, respiratory rhythm, neurotoxicity, nausea / emesis, pain and nociception.

Substance P and other sensory neuropeptides can be released from the peripheral terminals of sensory nerve fibers in the skin, muscle and joints.

Substance P receptor antagonists may have important therapeutic applications in the treatment of a variety of stress-related illnesses, in addition to their potential as analgesics.

Substance P antagonist ( SPA ) aprepitant is available in the market in the treatment of chemotherapy-induced nausea / emesis.

Substance P is involved in nociception, transmitting information about tissue damage from peripheral receptors to the central nervous system to be converted to the sensation of pain.

Substance P increases glutamate activity ( NMDA ) in central nervous system, and it is associated with the development of brain edema and functional deficits after traumatic brain injury.

Substance P has been known to stimulate cell growth in culture, and it was shown that substance P could promote wound healing of non-healing ulcers in humans.

Substance P injected into pancreatic nerves has been shown to reverse diabetes in mice but effects to insulin secretion seems to be species dependent.

Substance P also has effects as a potent vasodilator.

Substance P is involved in the axon reflex-mediated vasodilatation to local heating and wheal and flare reaction.

cs: Substance P

fr: Substance P

NGF is known to up-regulate neuropeptides, especially substance P. Substance P has been found to have an important role in inducing pain ; however, there is no confirmation that substance P directly causes acute sensitization.

Substance Z, an active urinary peptide, was purified by extraction in organic solvents and repeated column chromatography ; ;

] When he had done eating, he usually took a Kind of Chocolate, made after the Manner of the Country, that is, the Substance of the Nut beat up with the Mill till the Cup was filled more with Froth than with Liquor ; after which he used to smoak Tobacco perfum'd with liquid Amber.

Substance was an important album in collecting the group's 12-inch singles onto CD for the first time and featured new versions of " Temptation " and " Confusion "— referred to as " Temptation ' 87 " and " Confusion ' 87 ".

In the US, the track listing was altered to set it apart from Substance as well as the UK release of The Best of New Order which had been available months prior.

The two-disc release was an updated version of the Substance collection and contained every single released from their 1981 debut all the way through to " Waiting for the Sirens ' Call ".

The notion of a static unchanging Form and its identity with Substance represents the metaphysical view that has come to be held as an assumption by the vast majority of the Western philosophical tradition since Plato and Aristotle, as it was something they agreed on.

Simpson during his criminal trial for murder, Downey was sentenced to a three-year prison term at the California Substance Abuse Treatment Facility and State Prison in Corcoran, California ( a. k. a. " Corcoran II ").

After spending nearly a year in California Substance Abuse Treatment Facility and State Prison in Corcoran, California, Downey, on condition of posting $ 5, 000 bail, was unexpectedly freed when a judge ruled that his collective time in incarceration facilities ( spawned from the initial 1996 arrests ) had qualified him for early release.

Spinoza, who changed the anthropomorphic concept of God into that of an abstract, vague, underlying Substance, was praised by Hegel whose concept of Absolute fulfilled a similar function.

Substance and Shadow, published in Punch, 1843, the first use of the word cartoon to refer to a satirical drawingIt was in work for the wood-engravers that Leech was most prolific and individual.

In 1995, the touring exhibition The Art of Mary Pratt: The Substance of Light was organized by the Beaverbrook Art Gallery in Fredericton.

Konami has also released 4 " scale blind-box figures based on MGS2 released in Japan, Sons of Liberty in 2002 and Substance shortly after in 2003 ; the Substance series was eventually brought to the US and UK markets packaged on card rather than blind boxed.

Her debut novel, A Woman of Substance, was published in 1979 and has sold over 32 million copies worldwide.

Substance 1989 is the video version of Substance that first appeared in 1989 on VHS ; it was released on LaserDisc in Japan in 1991.

No Substance was anticipated by both music critics and fans as a result of the band's previous worldwide successes with their 1994 major label debut Stranger Than Fiction and its 1996 follow up The Gray Race.

To this was annexed a tract (" Matter not a Cogitative Substance ") to demonstrate the impossibility of thinking or perception being the result of any combination of the parts of matter and motion.

Its release was followed by an expanded edition, Metal Gear Solid 2: Substance for Xbox, PlayStation 2 and Microsoft Windows.

The game's music was released via 4 CDs: Metal Gear Solid 2: Sons of Liberty Original Soundtrack, Metal Gear Solid 2: Sons of Liberty Soundtrack 2: The Other Side, Metal Gear Solid 2: Substance Limited Sorter ( Black Edition ) and Metal Gear Solid 2: Substance Ultimate Sorter ( White Edition ).

The disc was included in the European PlayStation 2 version of Metal Gear Solid 2: Substance, but was not available at retail in that region.