Thalidomide () is a sedative drug introduced in the late 1950s that was used to treat morning sickness and to aid sleep.

Thalidomide was developed by German pharmaceutical company Grünenthal in Stolberg near Aachen.

Thalidomide, launched by Grünenthal on 1 October 1957, was found to act as an effective tranquilizer and painkiller, and was proclaimed a " wonder drug " for insomnia, coughs, colds, and headaches.

This compensation, which is distributed by the Thalidomide Trust in the UK, was substantially increased by Diageo in 2005.

The result was followed by more favorable experiences for the actual leprosy itself, and he followed by getting a Thalidomide clinical trial for leprosy.

Thalidomide was later reported to be effective against multiple myeloma, particularly in combination with dexamethasone.

Thalidomide was originally developed and prescribed as a cure for morning sickness in West Germany, but its use was discontinued when it was found to cause birth defects.

Starkweather was also featured in Billy Joel's song " We Didn't Start the Fire ", referenced in the first part of the line " Starkweather homicide, children of Thalidomide.

One such report was about the plight of hundreds of British Thalidomide children who had never had any compensation for severe birth defects some had suffered.

In November 1961, Thalidomide was taken off the market due to massive pressure from the press and public.

As a result of the Thalidomide scandal, the Health Law in Germany was strengthened and new requirements for pharmaceutical testings were created ; and the Federal Ministry of Health was established in 1962.

The lawsuit alleged that Chemie Grünenthal was negligent in the testing of Thalidomide, and that they failed to warn of its effects on unborn children.

By this time the company stated that Thalidomide was not recommended for use during pregnancy as such.

It was used in hindsight to strengthen the argument that doctors would interpret the word to mean that Thalidomide was safe during the final stage of pregnancy only.

This turned into a campaign for the newspaper's Insight investigative team, and Evans himself took on the drug companies responsible for the manufacture of Thalidomide, pursuing them through the English courts and eventually gaining victory in the European Court of Human Rights.

Thalidomide is a drug, first prepared in 1957 in Germany, prescribed for treating morning sickness in pregnant women.

The company invented and marketed Thalidomide as Contergan in 1957.

Thalidomide became an over the counter drug in Germany around 1960, and could be purchased without a prescription.

Experts estimate that the drug Thalidomide led to the death of approximately 2, 000 children and serious birth defects in more than 10, 000 children, about 5, 000 of them in Western Germany.

* The International Contergan Thalidomide Alliance website

Thalidomide is currently used for the treatment of other diseases, notably cancer and leprosy.

* July 30 – Damages totalling £ 485, 528 are awarded to 28 Thalidomide victims.

The UK Government gave survivors a grant of £ 20 million, to be distributed through the Thalidomide Trust, in December 2009.

Thalidomide has been used by Brazilian physicians as the drug of choice for the treatment of severe ENL since 1965.

Thalidomide is available to only a small number of patients in the UK, in general in specialist cancer treatment centres where research trials are taking place and where specialist doctors have experience in its use.

Thalidomide may reduce the levels of TNFα, and it is possible that the drug's effect on ENL is caused by this mechanism.

Thalidomide also has potent anti-inflammatory effects that may help ENL patients.

Thalidomide has also been found to be effective in treating actinic prurigo, an autoimmune skin disease.

Thalidomide has been used in chronic bullous dermatosis of childhood ( CBDC ) with encouraging results.

Thalidomide also inhibits the growth of new blood vessels ( angiogenesis ); this inhibition, which is suspected as a prime cause of the inhibition of normal development and growth of limbs, may be useful in treating macular degeneration and other diseases.

Thalidomide may be able to fight painful, debilitating aphthous lesions in the mouth and esophagus of AIDS patients that prevent them from eating.

The FDA formed a Thalidomide Working Group in 1994 to provide consistency between its divisions, with particular emphasis on safety monitoring.

Thalidomide is also being investigated for treating prostate cancer, glioblastoma, lymphoma, arachnoiditis, Behçet's disease, and Crohn's disease.

Thalidomide has been tested in humans as a single agent for the treatment of multiple myeloma due to its antiangiogenic activity.

Thalidomide may also cause side effects, such as polyneuropathy, fatigue, skin rash, and venous thromboembolism ( VTE ), or blood clots, which could lead to stroke or myocardial infarction.

Thalidomide is racemic – it contains both left-and right-handed isomers in equal amounts.

Thalidomide binds to and inactivates the protein cereblon, which is important in limb formation and leads to a teratogenic effect on fetal development.

* Thalidomide monograph from Chemical and Engineering News.

For example, he captured some persons from York County, who with teams were taking to Philadelphia the furniture of a man who had just been released from prison through the efforts of his wife, and who apparently was helpless to prevent the theft of his household goods.

The kiss outraged our friends but it was done and meanwhile had released in me all the remote, exciting premonitions of lust, all the mysterious sensations that I had imagined a truly consummated kiss would convey to me.

By the time the film was released we were three million dollars over-spent, war was imminent and the public apparently had forgotten all about Mother Cabrini.

A copy was released to the press.

Fuchs, after nine and a half years, was released, being given time off for good behavior.

The verdict brought vindication to the dead woman's stepson, Vincent Hengesbach, 54, who was tried for the same crime in December, 1958, and released when the jury failed to reach a verdict.

Although his respect for Aristotle was diminished as his travels made it clear that much of Aristotle's geography was clearly wrong, when the old philosopher released his works to the public, Alexander complained " Thou hast not done well to publish thy acroamatic doctrines ; for in what shall I surpass other men if those doctrines wherein I have been trained are to be all men's common property?

The radio broadcast of the September 8, 1937 Hollywood Bowl George Gershwin Memorial Concert, in which An American in Paris, also conducted by Shilkret, was second on the program, was recorded and was released in 1998 in a two-CD set.

In 1996, a tenth anniversary edition was released.

A port was in development for the 5200 and advertised as a launch title but never officially released, although an unofficial release was produced by AtariAge.

( This package was released for the PC a year earlier under the title Atari: 80 Classic Games in One.

Asteroids was released via Xbox Live Arcade for the Xbox 360 on November 28, 2007, with an option for special revamped HD graphics and a high-speed " throttle monkey " mode.

Rashomon, which premiered in Tokyo in August 1950, and which also starred Mifune, became, on September 10, 1951, the surprise winner of the Golden Lion at the Venice Film Festival and was subsequently released in Europe and North America.

The discovery was kept secret and only released to the public in November 1945.

However, no new edition was released before Guardians of Order went out of business in 2006.

Arista's refusal to release the album had two known effects: the negotiations led to a renewed contract and the album was never released.

In 2010 Eye to Eye: Alan Parsons Project Live in Madrid was released on CD.

An optional board providing a cassette interface for storage was later released at a cost of $ 72.

A software-compatible clone of the Apple I ( Replica 1 ), produced using modern components, was released in 2003 at a price of around $ 200.

The initial funds were released in September, and the 11-tube prototype was first demonstrated in October, 1939.