The N-terminal tails of histones H3 and H2B pass through a channel formed by the minor grooves of the two DNA strands, protruding from the DNA every 20 bp.

The molecule folds into 2 domains, an N-terminal catalytic domain, which contains the catalytic and cofactor binding sites, and comprises a central 9-stranded beta-sheet, surrounded by 5 helices ; and a C-terminal DNA recognition domain, which is formed by 4 small beta-sheets and 8 alpha-helices.

DNA binding occurs via an N-terminal helix-turn-helix structural motif and is targeted to one of several operator DNA sequences ( known as O < sub > 1 </ sub >, O < sub > 2 </ sub > and O < sub > 3 </ sub >).

The N-terminal " head domain " binds DNA.

Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle.

Polypeptide C-terminal thioesters produced by recombinant DNA techniques can be reacted with an N-terminal Cys containing polypeptide by the same native ligation chemistry to provide very large semi-synthetic proteins.

The recognition and binding to DNA by helix-turn-helix proteins is done by the two α helices, one occupying the N-terminal end of the motif, the other at the C-terminus.

Copper fist is an N-terminal domain involved in copper-dependent DNA binding.

It binds sites with single-strand breaks through its N-terminal zinc fingers and will recruit XRCC1, DNA ligase III, DNA polymerase beta, and a kinase to the nick.

In addition to C-terminal ligand-binding domains, these nuclear receptors contain a highly-conserved, N-terminal zinc-finger that mediates specific binding to target DNA sequences, termed ligand-responsive elements.

In common with other steroid receptors, the progesterone receptor has a N-terminal regulatory domain, a DNA binding domain, a hinge section, and a C-terminal ligand binding domain.

NTD = N-terminal domain, DBD = DNA binding domain.

In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine amino acid, which has been shown to be involved in ATP binding.

After binding to the receptors reelin is internalized by endocytosis, and the N-terminal fragment of the protein is re-secreted.

The active site is situated in the N-terminal half of the sequence, which includes a conserved Pro-Trp dipeptide ; the tryptophan has been shown to be involved in the binding of substrate by the enzyme.

For example, it has been shown to interact with fibrin, heparin, tenascin, TNF-α, BMP-1, rotavirus NSP-4, and many fibronectin binding proteins from bacteria ( like FBP-A ; FBP-B on the N-terminal domain ).

These enzymes contain a conserved motif Asp / Asn-Pro-Pro-Tyr / Phe in their N-terminal section, this conserved region could be involved in substrate binding or in the catalytic activity.

The N-terminal domain is conserved between dinoflagellate luciferase and luciferin binding proteins ( LBPs ).

A loop serving as the binding site for SAM links the N-terminal and the C-terminal domains of the Dot1 catalytic domain.

There is an N-terminal Zn ++ binding domain ( residues 1-110 ) where a zinc ion is tetrahedrally coordinated between one histidine and three cysteine residues, which may play a role in recognizing ssDNA.

The N-terminal tyrosine of dynorphin A is necessary to activate opioid receptors such as KOR, but is unnecessary in binding to bradykinin receptors.

The removal of the N-terminal residues ( Helicase and, RecQ-Ct domains ) impairs both helicase and ATPase activity but has no effect on the binding ability of RecQ implying that the N-terminus functions as the catalytic end.

The N-terminal EGF domain has been shown to at least in part be responsible for binding Tissue factor.

** e. g. repeat 6 of the ligand binding domain ( N-terminal, extracellular fluid ) is deleted.

Each KAR subunit begins with a 400 residue extracellular N-terminal domain, which plays a key role in assembly, followed by the 1st segment of the neurotransmitter binding cleft called S1.

They reported that acetylation of Lys5 near the N-terminal region and Lys29 in the beta-turn region led to substantial decreases in DTX-I binding affinity.

These results, along with many others, have implicated that the positively-charged lysines in the N-terminal half, particularly Lys5 in the 3 < sub > 10 </ sub >- helix, play a very important role in the dendrotoxin binding to their potassium channel targets.

The class C GPCRs are distinguished by their large N-terminal tail, which also contains a ligand-binding domain.

Ubiquitin-receptor proteins have an N-terminal ubiquitin-like ( UBL ) domain and one or more ubiquitin-associated ( UBA ) domains.

The critical event leading to the activation of p53 is the phosphorylation of its N-terminal domain.

The N-terminal transcriptional activation domain contains a large number of phosphorylation sites and can be considered as the primary target for protein kinases transducing stress signals.

Steroid receptors, on the other hand, may be repressive on gene expression when their transactivation domain is hidden ; activity can be enhanced by phosphorylation of serine residues at their N-terminal as a result of another signal transduction pathway, a process called crosstalk.

* an N-terminal HH-CC zinc-binding domain ( a three-helical bundle stabilised by coordination of a Zn ( II ) cation )

The New York Academy of Sciences corroborated the acceptance of these receptors stating that " Recent molecular biological studies have now identified strong candidates for umami receptors, including the heterodimer T1R1 / T1R3, and truncated type 1 and 4 metabotropic glutamate receptors missing most of the N-terminal extracellular domain ( taste-mGluR4 and truncated-mGluR1 ) and brain-mGluR4.

* Flavohaemoglobins ( FHb ): chimeric, with an N-terminal globin domain and a C-terminal ferredoxin reductase-like NAD / FAD-binding domain.

* Globin-coupled sensors: chimeric, with an N-terminal myoglobin-like domain and a C-terminal domain that resembles the cytoplasmic signalling domain of bacterial chemoreceptors.

* Protoglobin: a single domain globin found in archaea that is related to the N-terminal domain of globin-coupled sensors.

Type II and III are anchored with a signal-anchor sequence, with type II being targeted to the ER lumen with its C-terminal domain, while type III have their N-terminal domains targeted to the ER lumen.

Type IV is subdivided into IV-A, with their N-terminal domains targeted to the cytosol and IV-B, with an N-terminal domain targeted to the lumen.

Researchers are trying to target the ligand-binding domain and N-terminal domain of androgen receptors.

Compared to the X-ray crystal structure, the C-terminal domain solution structure is similar while the EF hands of the N-terminal domain are considerably less open.

HDV recognizes its receptor via the N-terminal domain of the large hepatitis B surface antigen, HBsAg.