All three known members of the selectin family ( l -, e -, and p-selectin ) share a similar cassette structure: an N-terminal, calcium-dependent lectin domain, an epidermal-growth-factor ( EGF )- like domain, a variable number of consensus repeat units ( 2, 6, and 9 for l -, e -, and p-selectin, respectively ), a transmembrane domain ( TM ) and an intracellular cytoplasmic tail ( cyto ).

The class C GPCRs are distinguished by their large N-terminal tail, which also contains a ligand-binding domain.

Ubiquitin-receptor proteins have an N-terminal ubiquitin-like ( UBL ) domain and one or more ubiquitin-associated ( UBA ) domains.

In the N-terminal extremity of the catalytic domain there is a glycine-rich stretch of residues in the vicinity of a lysine amino acid, which has been shown to be involved in ATP binding.

The critical event leading to the activation of p53 is the phosphorylation of its N-terminal domain.

The N-terminal transcriptional activation domain contains a large number of phosphorylation sites and can be considered as the primary target for protein kinases transducing stress signals.

Steroid receptors, on the other hand, may be repressive on gene expression when their transactivation domain is hidden ; activity can be enhanced by phosphorylation of serine residues at their N-terminal as a result of another signal transduction pathway, a process called crosstalk.

The N-terminal DNA binding domain ( labeled ) of lac repressor | lac repressor binds the its target DNA sequence ( gold ) in the major groove using a helix-turn-helix motif.

* an N-terminal HH-CC zinc-binding domain ( a three-helical bundle stabilised by coordination of a Zn ( II ) cation )

The New York Academy of Sciences corroborated the acceptance of these receptors stating that " Recent molecular biological studies have now identified strong candidates for umami receptors, including the heterodimer T1R1 / T1R3, and truncated type 1 and 4 metabotropic glutamate receptors missing most of the N-terminal extracellular domain ( taste-mGluR4 and truncated-mGluR1 ) and brain-mGluR4.

* Flavohaemoglobins ( FHb ): chimeric, with an N-terminal globin domain and a C-terminal ferredoxin reductase-like NAD / FAD-binding domain.

* Globin-coupled sensors: chimeric, with an N-terminal myoglobin-like domain and a C-terminal domain that resembles the cytoplasmic signalling domain of bacterial chemoreceptors.

* Protoglobin: a single domain globin found in archaea that is related to the N-terminal domain of globin-coupled sensors.

For example, it has been shown to interact with fibrin, heparin, tenascin, TNF-α, BMP-1, rotavirus NSP-4, and many fibronectin binding proteins from bacteria ( like FBP-A ; FBP-B on the N-terminal domain ).

Type II and III are anchored with a signal-anchor sequence, with type II being targeted to the ER lumen with its C-terminal domain, while type III have their N-terminal domains targeted to the ER lumen.

Type IV is subdivided into IV-A, with their N-terminal domains targeted to the cytosol and IV-B, with an N-terminal domain targeted to the lumen.

Researchers are trying to target the ligand-binding domain and N-terminal domain of androgen receptors.

Compared to the X-ray crystal structure, the C-terminal domain solution structure is similar while the EF hands of the N-terminal domain are considerably less open.

HDV recognizes its receptor via the N-terminal domain of the large hepatitis B surface antigen, HBsAg.

The N-terminal tail of histone H4, on the other hand, has a region of highly basic amino acids ( 16-25 ), which, in the crystal structure, forms an interaction with the highly acidic surface region of a H2A-H2B dimer of another nucleosome, being potentially relevant for the higher-order structure of nucleosomes.

: The N-terminal methionine usually found after translation has an N-terminus blocked with a formyl group.

This has a hexameric structure built from right-handed 4-helix bundles, each containing N-terminal hooks that chelate a Ni ion.

It also has been shown that the N-terminal region of reelin, a site distinct from the region of reelin shown to associate with VLDLR / ApoER2 binds to the alpha-3-beta-1 integrin receptor.

The active site is situated in the N-terminal half of the sequence, which includes a conserved Pro-Trp dipeptide ; the tryptophan has been shown to be involved in the binding of substrate by the enzyme.

Each PRMT has a unique N-terminal region and a catalytic core.

The N-terminal fragment 1-34 of parathyroid hormone ( PTH ) has been crystallized and the structure has been refined to 0. 9 Å resolution.

The N-terminal domain of the non structural protein 5 ( NS5 ) has both the N7-methyltransferase and guanylyltransferase activities necessary for forming mature RNA cap structures.

Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle.

The N-terminal has a multi-helical structure that forms an orthogonal bundle.

The N-terminal fragment of parathyroid hormone ( PTH 1-34 ) has full biological activity.

NS3 is 67 kDa protein whose N-terminal has serine protease activity and whose C-terminal has NTPase / helicase activity.

In fact, in mammals, the peroxisomal enzyme has an extra N-terminal domain that is not present in the mitochondrial counterpart.

The origin of the spring-loaded mechanism lies within the exposed gp41, which has two heptad repeat repeats located at the N-terminal ( HR1 ) as well as the C-terminal ( HR2 ) side of the protein.

Because the Edman degradation proceeds from the N-terminus of the protein, it will not work if the N-terminal amino acid has been chemically modified or if it is concealed within the body of the protein.

The removal of the N-terminal residues ( Helicase and, RecQ-Ct domains ) impairs both helicase and ATPase activity but has no effect on the binding ability of RecQ implying that the N-terminus functions as the catalytic end.

Because the Edman degradation proceeds from the N-terminus of the protein, it will not work if the N-terminal amino acid has been chemically modified or if it is concealed within the body of the protein.

Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum.

This technique allows for access to much larger proteins, as only the N-terminal portion of the resulting protein has to be chemically synthesized.

Intracellular recognition of viral double-stranded ( ds ) and single stranded RNA has been shown to be mediated by a group of RNA Helicases which in turn recruit factors via twin N-terminal CARD domains to activate antiviral gene programs.

CDR3 is the main CDR responsible for recognizing processed antigen, although CDR1 of the alpha chain has also been shown to interact with the N-terminal part of the antigenic peptide, whereas CDR1 of the β-chain interacts with the C-terminal part of the peptide.

In another patient, it was shown that CAIS was the result of a deficit in the transmission of a transactivating signal from the N-terminal region of the normal androgen receptor to the basal transcription machinery of the cell.

Most thylakoid proteins encoded by a plant's nuclear genome need two targeting signals for proper localization: An N-terminal chloroplast targeting peptide ( shown in yellow in the figure ), followed by a thylakoid targeting peptide ( shown in blue ).