In September 2009, Pfizer pleaded guilty to the illegal marketing of the arthritis drug Bextra for uses unapproved by the FDA, and agreed to a $ 2. 3 billion settlement, the largest health care fraud settlement at that time.

Pfizer lost nearly $ 1 billion invested developing the failed drug, and the market value of the company plummeted in the aftermath.

** Varenicline tartrate is a prescription drug marketed by Pfizer as Chantix in the U. S. ( under FDA approval ) and as Champix outside the U. S. Synthesized as an improvement upon cytisine, varenicline decreases the urge to smoke and reduces withdrawal symptoms .< ref > Two systematic reviews and meta-analyses supported by unrestricted funding from Pfizer, one in 2006 and one in 2009, found varenicline more effective than NRT or bupropion.

Key orphan drug developers including Synageva BioPharma Corp., Swedish Orphan Biovitrum, Shire plc, GlaxoSmithKline, Pfizer, Novartis, Genzyme, Lundbeck, Prosensa and BioMarin are leading the way in this growing industry.

Atorvastatin ( INN ) (), marketed by Pfizer as a calcium salt under the trade name Lipitor, is a member of the drug class known as statins, used for lowering blood cholesterol.

Pfizer also packages the drug in combination with other drugs, such as with Caduet.

The drug was at the core of a major patent dispute that was resolved in Searle's favor ( later Pfizer ) in 2004.

Daniel L. Simmons of Brigham Young University, who discovered the COX-2 enzyme, is suing Pfizer to be credited with discovery of the technique in 1989 that eventually led to the drug, and for $ 1 billion USD.

The drug was originally researched as a treatment for cardiovascular diseases such as hypertension and angina, but focus quickly shifted to ED with the success of another PDE5 inhibitor, sildenafil ( Viagra ), which had been developed by Pfizer.

An example is the Taiwanese Mandarin word 威而剛 wēiérgāng ( weiergang ), which literally means " powerful and hard " and refers to Viagra, the drug for treating impotence in men, manufactured by Pfizer.

The CFPPC was particularly concerned with $ 15, 000 Marin received from the drug company Pfizer in 2007 which was simultaneously lobbying the Board of Pharmacy, a regulatory panel under her jurisdiction, and $ 13, 500 from Bristol-Myers Squibb in 2008 when it was likewise lobbying agencies she oversaw.

At the time, Pfizer was preparing to release its drug Chantix ( Varenicline ) into the Middle Eastern market.

This has been highly value generating: for example PA created a third-generation mobile phone business called UbiNetics which was sold in two tranches for a total of $ 133 million in 2005 ; and Meridica-a drug delivery system company-was valued at time of sale to Pfizer at $ 125 million in 2004.

In 2004, Pfizer " admitted that Parke-Davis aggressively marketed Neurontin by illicit means for unrelated conditions including bipolar disorder, pain, migraine headaches, and drug and alcohol withdrawal ", and consented to $ 430 million dollars in penalties although it claimed the violations originated in 1996, well before Pfizer's acquisition of Warner-Lambert.

Pfizer subsidiary Warner-Lambert illegally used scientific activities, including continuing medical education and research, to commercially promote gabapentin, so that within 5 years the drug was being widely used for the off-label treatment of pain and psychiatric conditions-conditions that had not been approved by FDA.

SSRI drugs, which have an important use as antidepressants, are considered to cause physical dependence, although it is considered mild compared to drugs like opioids and GABA modulators, but they engender a discontinuation syndrome, which was originally called " SSRI withdrawal " until a 1997 symposium sponsored by Pfizer and Eli Lilly ( the producers of several anti-depressants including Prozac and Effexor ) was held, with the drug representative attendees concluding that " discontinuation syndrome " sounded less threatening than " withdrawal "; however, " SSRI discontinuation syndrome " is a withdrawal syndrome upon discontinuation of SSRI / SNRI drugs, just as " heroin discontinuation syndrome " is a synonym for " heroin withdrawal ".

Dr. Reddy ’ s Para 4 application strategy for generic business received a severe setback when Reddy ’ s lost the patent challenge in the case of Pfizer ’ s drug Norvasc ( amlodipine maleate ), a drug indicated for the treatment of hypertension and angina.

Because of this, diphenoxylate is manufactured and marketed as a combination drug with atropine ( Lomotil, Pfizer ) as an abuse deterrent.

In 1996, Eisai received approval from the United States Food and Drug Administration ( USFDA ) for Aricept ( donepezil ), a drug discovered in the company's labs and co-marketed with Pfizer.

* FDA advisors have recommended that Pfizer be required to place a boxed warning on their non-steroidal anti-inflammatory drug Celebrex ( celecoxib ) for cardiovascular and gastrointestinal risks.

Pfizer described in an SEC filing that the drug could be used to treat epilepsy, post-herpetic neuralgia, diabetic peripheral neuropathy and fibromyalgia.

At Pfizer, Tweddell worked on drug development and medical relations.

The pharmaceutical company Pfizer was founded in Brooklyn in 1869 and had a manufacturing plant in the borough for many years that once employed thousands of workers, but the plant shut down in 2008.

World War I caused a shortage of calcium citrate that Pfizer imported from Italy for the manufacture of citric acid, and the company began a search for an alternative supply.

The discovery and commercialization of Terramycin ( oxytetracycline ) by Pfizer in 1950 moved the company on the path of change from a manufacturer of fine chemicals to a research-based pharmaceutical company.

The local economy has benefited from significant investment by Pfizer UK, the British subsidiary of the multinational pharmaceuticals company Pfizer, which has built a research and development centre near Sandwich, employing over 3, 000 people.

He worked for many years for the large pharmaceutical company Parke Davis, which was later acquired by Pfizer.

The pharmaceutical company Pfizer also has operations located there, which in recent years has caused much controversy due to layoffs.

The group had to overcome initial bureaucratic reluctance to pursue sertraline development, as Pfizer was considering licensing an antidepressant candidate from another company.

* Cadbury Adams, confectionery company acquired by Cadbury from Pfizer in 2003

The Bjork – Shiley heart valve was manufactured by Pfizer after they bought the Shiley company in 1979.

He is currently a lobbyist for Pfizer and chairman of QTC Management, a company that works on contracts for the Veterans Affairs Department.

* Warner-Lambert, now merged with Pfizer, a pharmaceutical company

Some years later, Shiley decided to sell his company to Pfizer, and retired.

" The 2008 award was instead given to Jeff Kindler, chief executive of pharmaceutical company Pfizer.

German immigrant, chemist Charles Pfizer founded Pfizer Pharmaceutical in Williamsburg, and the company maintained an industrial plant in the neighborhood through 2007, although its headquarters were moved to Manhattan in the 1960s.

It was co-promoted by Monsanto Company ( parent company of Searle ) and Pfizer under the brand name Celebrex.

The pharmaceutical company Pfizer is also a major employer.

Pfizer is one of the world ’ s largest pharmaceutical companies, and the company maintains a research and development facility in Groton.

He then practiced law as a patent attorney for more than a decade, spending the last six years of his legal career at the pharmaceutical company Pfizer.

Every major company selling the drugs — Bristol-Myers Squibb, Eli Lilly, Pfizer, AstraZeneca and Johnson & Johnson — has either settled recent government cases, under the False Claims Act, for hundreds of millions of dollars or is currently under investigation for possible health care fraud.