However, depletion of HAUSP does not result to a decrease in p53 levels but rather increases p53 levels due to the fact that HAUSP binds and deubiquitinates Mdm2.

The symptoms of esophageal spasm, erectile dysfunction, and abdominal pain are attributed to the fact that hemoglobin released during hemolysis binds with circulating nitric oxide, a substance that is needed to relax smooth muscle.

In fact, it has been shown that Swi6 ( the homolog of HP-1 in S. pombe ) binds to methylated Lys 9 of histone H3 and promotes the binding of cohesin to the centromeric repeats in S. pombe.

I am in fact in no way more important than is the typesetter for my books, the man who works the mill ; ... no more important than the man who binds my books and the woman who wraps them and the scrubwoman who cleans up the office.

In fact almost anything that binds a given target with high affinity can be used as an antigen recognition region.

Its name derives from the fact that it directly tests the presence of an antigen with the tagged antibody, unlike western blotting, which uses an indirect method of detection, where the primary antibody binds the target antigen, with a secondary antibody directed against the primary, and a tag attached to the secondary antibody.

The Sierra Miwok preferentially exploited acorns from the California Black Oak, Quercus kelloggii ; in fact, the modern-day extent of the California Black Oak forests in some areas of Yosemite National Park is partially due to preferential cultivation by Miwok tribes.

The photochemical reaction cells consisted of 10 mm. i.d. Pyrex tubing, 5.5 cm. long, diffraction effects being minimized by the fact that the light passed through only liquid-glass interfaces and not gas-glass interfaces.

In fact agglutination of Af cells in saline could be produced by the insoluble material from sera containing `` only '' incomplete antibody activity.

According to bundle theory, an object consists of its properties and nothing more: thus neither can there be an object without properties nor can one even conceive of such an object ; for example, bundle theory claims that thinking of an apple compels one also to think of its color, its shape, the fact that it is a kind of fruit, its cells, its taste, or at least one other of its properties.

The prominence of the Nissl substance can be explained by the fact that nerve cells are metabolically very active, and hence are involved in large amounts of protein synthesis.

Despite the fact that all are nerve cells, only the retinal ganglion cells and few amacrine cells create action potentials.

* Coelomic metaplasia: This theory is based on the fact that coelomic epithelium is the common ancestor of endometrial and peritoneal cells and hypothesizes that later metaplasia ( transformation ) from one type of cell to the other is possible, perhaps triggered by inflammation.

The values shown in the cells of the table are not without controversy, for the precise meanings of some of the concepts involved are unclear and, in fact, are themselves at the center of the controversy surrounding the given interpretation.

The two types are differentiated by the fact that the hyphae of ectomycorrhizal fungi do not penetrate individual cells within the root, while the hyphae of endomycorrhizal fungi penetrate the cell wall and invaginate the cell membrane.

The original hypothesis, that the protein is a stop signal for the migrating cells, is supported by its ability to induce the dissociation, its role in asserting the compact granule cell layer in the hippocampus, and by the fact that migrating neuroblasts evade the reelin-rich areas.

That fact facilitates spreading of tumors cells through these lymphatics in cases of cancers of the stomach and particularly of the esophagus.

Low Earth orbit satellites take advantage of the fact that certain polar orbits set near the terminator do not suffer from eclipse, therefore their solar cells are continuously lit by sunlight.

This fact gave rise to the idea that spontaneous autoimmunity may result when the binding of antibody to certain antigens leads to aberrant signals being fed back to parent B cells through membrane bound ligands.

( Note that the idea that all cells come from pre-existing cells had in fact already been proposed by Robert Remak ; it has been suggested that Virchow plagiarised Remak.

This fact, combined with a fluorescence readout capability and their ubiquitous presence in biology laboratories, suggests that DNA sequencers may be used to study temperature dependent events in cells.

More importantly for biomaterials research, however, is the fact that, when dried, the mucin provides a suitable substrate for the attachment of living cells.

This finding was published in the journals Science ( 2008 ) and Genes and Development ( 2007 ) together with the fact that endothelial progenitor cells are critical for metastasis and angiogenesis.

The fact that malignant cells could be seen under the microscope was first pointed out in a book on diseases of the lung, by Walter Hayle Walshe ( 1812 – 92 ), professor and physician to University College Hospital, London, in 1843.

The light weight of the wood derives from the fact that the tree has large cells that contain water.

The cells in Bowen's are often highly atypical under the microscope, and may in fact look more unusual than the cells of some invasive squamous cell carcinomas.

In fact Pinot meunier has been shown to be a chimerical mutation ( in the epidermal cells ) which makes the shoot tips and leaves prominently hairy-white and the vine a little smaller and early ripening.

In fact it has caused us to give serious thought to moving our residence south, because it is not easy for the most objective Southerner to sit calmly by when his host is telling a roomful of people that the only way to deal with Southerners who oppose integration is to send in troops and shoot the bastards down.

While the pattern is uneven, some having gained more than others, nationalism has in fact served the Western peoples well.

according to many critics, in fact, the South has led the North in literature since the Civil War, both quantitatively and qualitatively.

In fact, the recent warnings about the use of X-rays have introduced fears and ambiguities of action which now require more detailed understanding, and thus in this instance, science has momentarily aggravated our fears.

Whether historically a fact or not, the legend has a certain symbolic value.

This sentence would have most of the characteristics of a question, but it has some of the characteristics of a statement because the questioner has conveyed the fact that he has no faith in his own timepiece or the one attached to his car.

`` We were possessed by visions of a new civilization to come, very pure and elevated '', he has said, `` in fact some ideal form of socialism such as we had dreamed of since the war of 1914-1918 ''.

That is not to deny that he has been aware of traditions, of course, that he is steeped in them, in fact, or that he has dealt with them, in his books.

The fact that he has cast over those materials the light of a skeptical mind does not make him any the less Southern, I rather think, for the South has been no more solid than other regions except in the political and related areas where patronage and force and intimidation and fear may produce a surface uniformity.

His point is simply that the Tories have showered him with personal satire, despite the fact that as a private subject he has a right to speak on political matters without affronting the prerogative of the Sovereign.

In fact, modern scholarly opinion in the main has not retreated all the way back to the destructive scepticism of the first half of the nineteenth century.

Because of the means of publication -- science-fiction magazines and cheap paperbacks -- and because dystopian science fiction is still appearing in quantity the full range and extent of this phenomenon can hardly be known, though one fact is evident: the science-fiction imagination has been immensely fertile in its extrapolations.

No good can come of contemplating the sad, inevitable fact that once youth has passed `` a worse and worse time still succeeds the former ''.

He has shown considerable ingenuity in adapting his earliest symbols and devices to the new work, and the fact that he has kept a body of constant symbols through all of his experiments gives an unexpected continuity to his poetry.

They insisted on the `` fundamental fact '' that `` the whole of Berlin has a quadripartite status ''.

But if anything can bring home to Mr. Khrushchev the idea that he will not really get much enjoyment from watching this Braddock-against-the-Indians contest, it will probably be the fact that SEATO forces are ready to attempt it -- plus the fact that Moscow has something to lose from closing off disarmament and other bigger negotiations with Washington.

The main question raised by the incident is how much longer will UN bury its head in the sand on the Congo problem instead of facing the bitter fact that it has no solution in present terms??

In fact, over the years, the American farmer's capacity to over-produce has cost the taxpayers a large dollar.

But more than one conscientious researcher has been inhibited from completely frank discussion of the available evidence by the less excusable fact that fallout has been made a political issue as well as a scientific problem.