In pregnant women, ACE inhibitors taken during the first trimester have been reported to cause major congenital malformations, stillbirths, and neonatal deaths.

Their use in the first trimester is also associated with a risk of major congenital malformations, particularly affecting the cardiovascular and central nervous systems.

Lamellar bone, which makes its first appearance in the fetus during the third trimester, is stronger and filled with many collagen fibers parallel to other fibers in the same layer ( these parallel columns are called osteons ).

Love claimed she was misquoted, and asserted that she immediately quit using the drug during her first trimester after she discovered she was pregnant.

Chemotherapy is potentially teratogenic during pregnancy, especially during the first trimester, to the extent that abortion usually is recommended if pregnancy in this period is found during chemotherapy.

For instance, if a state fatwā council made abortion acceptable in the first trimester without any medical reason, that would have direct impact on official procedures in hospitals and courts in that country.

The mothers themselves suffer from exacerbated myasthenia in a third of cases, and in those for whom it does worsen, it usually occurs in the first trimester of pregnancy.

However, one meta-analysis looking at the outcome of pregnancies involving Quinolone use in the first trimester found no increased risk of malformations.

This condition, however, usually results in spontaneous miscarriage in the first trimester.

Approximately 99 percent of all fetuses with Turner syndrome result in spontaneous termination during the first trimester.

The mother and fetus are also usually imaged in the first trimester of pregnancy.

This is done to predict problems with the mother ; confirm that a pregnancy is present inside the uterus ; estimate the gestational age ; determine the number of fetuses and placentae ; evaluate for an ectopic pregnancy and first trimester bleeding ; and assess for early signs of anomalies.

X-rays and computerized tomography ( CT ) are not used, especially in the first trimester, due to the ionizing radiation, which has teratogenic effects on the fetus.

Instead, obstetric ultrasonography is the imaging method of choice in the first trimester and throughout the pregnancy, because it emits no radiation, is portable, and allows for realtime imaging.

Obstetric ultrasonography is routinely used for dating the gestational age of a pregnancy from the size of the fetus, the most accurate dating being in first trimester before the growth of the fetus has been significantly influenced by other factors.

Development of the maternal blood supply to the placenta is complete by the end of the first trimester of pregnancy ( approximately 12 – 13 weeks ).

The statistic was given that “ 50 percent of the mothers with deformed children had taken thalidomide during the first trimester of pregnancy .” Throughout Europe, Australia, and the United States, 10, 000 cases were reported of infants with phocomelia ; only 50 % of the 10, 000 survived.

The myofibroblasts are absent in the first trimester in the embryonic stage ; damage then heals scar free ; small incisional or excision wounds less than 2 mm also heal without scarring ; and in adult unwounded tissues where the fibroblast in itself is arrested ; however, the myofibroblast is found in massive numbers in adult wound healing which heals with a scar.

The use of sertraline during the first trimester of pregnancy was associated with increased odds of the following birth defects: omphalocele ( six-fold ), anal atresia and limb reduction defects ( four-fold ), and septal defects ( two-fold ); however these specific defects themselves are rare and therefore the absolute risks are small.

In vanishing twin pregnancies with a second gestational sac with a dead fetus, first trimester screening should be based solely on the maternal age and the nuchal translucency scan as biomarkers are significantly altered in these cases.

The aerosolized route of administration is particularly suited for pregnant women in their first trimester ( when TMP-SMX is contraindicated ).

" Going into the absolute cold of Between during the first trimester of pregnancy usually causes a miscarriage ; therefore any female dragonrider risks aborting before she even knows she is with child.

Even the knowledge that she was losing another boy, as a mother always does when a marriage is made, did not prevent her from having the first carefree, dreamless sleep that she had known since they dropped down the canyon and into Bear Valley, way, way back there when they were crossing those other mountains.

And that is the way I first saw her when my Uncle brought her into his antique store.

Why, in the first place, call himself a liberal if he is against laissez-faire and favors an authoritarian central government with womb-to-tomb controls over everybody??

Life is further characterized, in antithesis to Piepsam, as animal: the image of a dog, which appears at several places, is first given as the criterion of amiable, irrelevant interest aroused by life considered simply as a spectacle: a dog in a wagon is `` admirable '', `` a pleasure to contemplate '' ; ;

In the first instance, `` mimesis '' is here used to mean the recalling of experience in terms of vivid images rather than in terms of abstract ideas or conventional designations.

This is the primary function of the imagination operating in the absence of the original experiential stimulus by which the images were first appropriated.

The first half of The Charles Men, ending on the climax of the battle of Poltava in 1709, is more dramatically coherent than the second.

He is, first and foremost, a defender of public morals, a servant of society.

The first of two possible variations on this theme is symbolized by Mickey Spillane's Mike Hammer.

Noting such evidence is the first step ; ;

So it is that we relive his opening statement in the first television address with the dramatic immediacy of the present.

and it is surely clear that the first of these is the result of the way in which the individual's command of language interacts with the other two.

The first thing to do is get her some money by a temporary but definite adjustment pending a final disposition of the case.

When I take over Taliesin, the first thing I'll do is fire you ''.

If `` Jack the Courtier '' is really to be taken as Swift, the following remark is obviously Steele's comment on Swift's change of parties and its effect on their friendship: `` I assure you, dear Jack, when I first found out such an Allay in you, as makes you of so malleable a Constitution, that you may be worked into any Form an Artificer pleases, I foresaw I should not enjoy your Favour much longer ''.

At this point a working definition of idea is in order, although our first definition will have to be qualified somewhat as we proceed.

`` History has this in common with every other science: that the historian is not allowed to claim any single piece of knowledge, except where he can justify his claim by exhibiting to himself in the first place, and secondly to any one else who is both able and willing to follow his demonstration, the grounds upon which it is based.

We saw it frequently afterward, but our suggestion for the very first encounter is near sunset.

Master Gorton, having foully abused high and low at Aquidneck is now bewitching and bemaddening poor Providence, both with his unclean and foul censures of all the ministers of this country ( for which myself have in Christ's name withstood him ), and also denying all visible and external ordinances in depth of Familism: almost all suck in his poison, as at first they did at Aquidneck.