The general acceptance of the idea of governmental ( i.e., societal ) responsibility for the economic well-being of the American people is surely one of the two most significant watersheds in American constitutional history.

As symptomatic of the common man's malaise, he is most significant: a liberal and a Catholic, elected by the skin of his teeth.

Of all the Whig tracts written in support of the Succession, The Crisis is perhaps the most significant.

One of the most significant advancements in design of plastics signs is the so-called trans-illuminated billboard, now being produced by several large sign manufacturers such as Advance Neon Sign Co., Los Angeles, and Industrial Electric Inc., New Orleans, La..

Other than this very significant result, most of the information now available about the radio emission of the planets is restricted to the intensity of the radiation.

Statistically, the most significant data have been collected from the sensors on 1958 Alpha ( Explorer 1 ), 1958 Delta 2 ( Sputnik 3 ), and 1959 Eta ( Vanguard 3 ).

Such conversation quickly reveals an ethically significant ambivalence in the self-images held by most realtors.

Aristotle not only studied almost every subject possible at the time, but made significant contributions to most of them.

The group of elements is more diverse than the lanthanides and therefore it was not until 1945 that Glenn T. Seaborg proposed the most significant change to Mendeleev's periodic table, by introducing the actinides.

Alpha, both as a symbol and term, is used to refer to or describe a variety of things, including the first or most significant occurrence of something.

Among Poirot's most significant personal attributes is the sensitivity of his stomach:

In the Southwest, mountain ranges, rivers and, most obviously, the Grand Canyon can be significant barriers for human communities, likely reducing the frequency of contact with other groups.

The lives of numerous abbots make up a significant contribution to Christian hagiography, one of the most well-known being the Life of St. Benedict of Nursia by St. Gregory the Great.

The basic design remained unchanged for centuries, with the most significant changes being to the overall proportions, and a move from wooden stocks to those of iron.

Historic Swabia was eventually replaced by today's Baden-Württemberg, but it had been the most significant territory of mediaeval Alamannia, comprising all Germania Superior and territory east to Bavaria.

Hence, if a dish contains significant amounts of any of these ingredients, it has most likely been Americanized.

The most significant moderate proposal was the Fourteenth Amendment, also written by Trumbull.

The most significant of these is the story about Ambrosius, Vortigern, and the two dragons beneath Dinas Emrys, " Fortress of Ambrosius " in Chapters 40 – 42.

On the subject of charity Andrew Carnegie's actions diverged in the most significant and complex manner from Herbert Spencer's philosophies.

Although the hardware is limited to four separate sound channels, software such as OctaMED uses software mixing to allow eight or more virtual channels, and it was possible for software to mix two hardware channels to achieve a single 14-bit resolution channel by playing with the volumes of the channels in such a way that one of the source channels contributes the most significant bits and the other the least.

Naamani Tarkow has written: " If one is to make sweeping statements, one may say that, save Magna Carta ( more truly, its implications ), the Act of Settlement is probably the most significant statute in English history ".

Dunn, who was tied for the major league lead with 32 home runs, was expected to provide a significant boost to an offense that has struggled to score runs for most of the season.

Sunday family dinner is considered the most significant meal of the week, whose highlights often include asado or pasta.

From the 1960s through the 1980s, " by far the most significant developments in the design and construction of acoustic guitars " were made by the Ovation Guitar Company.

Moreover, these combination analgesics can often result in significant adverse events, including accidental overdoses, most often due to confusion which arises from the multiple ( and often non-acting ) components of these combinations.

The league workers search out the pros and cons of the most complex issues and make them available to the public.

From the very beginning the electoral discussions raised fundamental issues in Moroccan politics, precisely the type of questions that were most difficult to resolve in the new government.

All too often its conception of parish ministry and pastoral care includes no responsibility for them in their relation to issues of the most desperate urgency for the life of mankind.

Germany and Norway are the countries that showed the most division and conflict between scholars focusing on domestic socio-cultural issues and scholars focusing on " other " societies ..

Thus most Affidavits now require to be Apostilled if used for cross border issues.

Among the many volumes of the holy Rabbi Yitzchak Luria ( known as the " Ari "), most of which come downfrom the pen of his primary disciple, Rabbi Chaim Vital, are profound insights explaining issues related to reincarnation.

This can have important consequences when dealing with issues such as consensual sadomasochistic sexual activity, the most notable case being the Operation Spanner case.

Wallace was a prolific author who wrote on both scientific and social issues ; his account of his adventures and observations during his explorations in Indonesia and Malaysia, The Malay Archipelago, was one of the most popular and influential journals of scientific exploration published during the 19th century.

A review of the methods used in trials of antipsychotics, despite stating that the overall quality is " rather good ," reported issues with the selection of participants ( including that in schizophrenia trials up to 90 % of people who are generally suitable do not meet the elaborate inclusion and exclusion criteria, and that negative symptoms have not been properly assessed despite companies marketing the newer antipsychotics for these ); issues with the design of trials ( including pharmaceutical company funding of most of them, and inadequate experimental " blinding " so that trial participants could sometimes tell whether they were on placebo or not ); and issues with the assessment of outcomes ( including the use of a minimal reduction in scores to show " response ," lack of assessment of quality of life or recovery, a high rate of discontinuation, selective highlighting of favorable results in the abstracts of publications, and poor reporting of side-effects ).

At its most recent meeting, November 27 – December 1, 2006, the Conference of the Parties of the Basel Agreement focused on issues of electronic waste and the dismantling of ships.

Moreover, as with most engineers, they often deal with management, economic and legal issues.

Regulatory issues are of particular concern to a biomedical engineer ; it is among the most heavily-regulated fields of engineering, and practicing biomedical engineers must routinely consult and cooperate with regulatory law attorneys and other experts.

The broad field of animal communication encompasses most of the issues in ethology.

* the standard of review and degree of deference given by an appellate tribunal to the decision of the lower tribunal under review ( issues of law are reviewed de novo, that is, " as if new " from scratch by the appellate tribunal, while most issues of equity are reviewed for " abuse of discretion ," that is, with great deference to the tribunal below ).

It also participates in most international conferences on economic and political issues.

Verbal report is widely considered to be the most reliable indicator of consciousness, but it raises a number of issues.

Two of the most popular are Penny Arcade, focused primarily on video gaming, and User Friendly, which bases its humor on the Internet and other computer-user issues.

In most cases, the Council votes on issues by qualified majority voting, meaning that there must be a minimum of 255 votes out of 345 ( 73. 9 %) and a majority of member states ( sometimes a two – third majority ).

For example, most law students in the United States are required to take a class in Constitutional Law during their first year, and several law journals are devoted to the discussion of constitutional issues.

It should be noted, however, that the Class Action Fairness Act contains carve-outs for, ' inter alia ', shareholder class actions covered by the Private Securities Litigation Reform Act of 1995 and those concerning internal corporate governance issues ( the latter typically being brought as shareholder derivative actions in the state courts of Delaware, the state of incorporation of most large corporations ).

By 1850, Parliament had enacted several statutes on a case-by-case basis to deal with issues regularly faced by certain types of organizations, like joint-stock companies, and with the impetus for most types of group litigation removed, it went into a steep decline in English jurisprudence from which it never recovered.

It is usually at the retreat where, isolated from their advisers, the heads resolve the most intransigent issues: leading to the Gleneagles Agreement in 1977, the Lusaka Declaration in 1979, the Langkawi Declaration in 1989, the Millbrook Programme in 1995, and the Aso Rock Declaration in 2003.