This binding serves to seal off the end grain of the top and back.

The Court of Final Appeal now serves as the highest judicial authority in the jurisdiction, although, as confirmed by the Court of Appeal, decisions of the Privy Council before 1 July 1997 on appeals from Hong Kong ' continue to be binding since the resumption of sovereignty on all courts of Hong Kong, save for the Court of Final Appeal ' i. e. these decisions remain part of the common law of the Hong Kong SAR unless and until overturned by the Court of Final Appeal.

Lear ’ s contest of love serves as the binding agreement ; his daughters will get their inheritance provided they care for him, especially Cordelia, whose " kind nursery " he will greatly depend on.

The cysteine residue at 302 in ALDH1 and 200 in ALDH2 is implicated as a disulfiram binding site on the enzyme and serves as a disfulfiram sensitive thiol site.

In the chloroplasts of the unicellular algae Chlamydomonas reinhardtii the PDI RB60 serves as a redox sensor component of an mRNA binding protein complex implicated in the photo-regulation of the translation of psbA, the RNA encoding for the photosystem II core protein D1.

The hydrophobic N-terminus of Sar1-GTP then locates it to the membrane, where it serves as the binding site for the Sec23 / Sec24 protein coat complex.

E1 serves as the fusogenic subunit and that E2 acts as the receptor binding protein.

This serves to improve the skin's moisture binding capacity, which is beneficial in the treatment of dry skin.

Both the N-and C-terminal domains contain heparin binding sites distal to the lipid binding sites ; LPL therefore serves as a bridge between the cell surface and lipoproteins.

It is applied to the wells just before adding samples, and serves to eliminate interference or non-specific binding that may occur due to the specimen matrix.

* The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures.

This positive regulatory binding of downstream targets to GAP serves as a negative feedback loop which eventually turns off the signaling that was originally activated.

The owner of the document took a lump of soft clay ; he affixed the clay to the string binding the document and then stamped it with his seal.

Restraint imposed on a vendor of business must be reasonable and is binding if there is a genuine seal of goodwill.

To secure the initial stitches of a knitted fabric, a method for casting on is used ; to secure the final stitches in a wale, one uses a method of binding off.

Vertical and horizontal edges can be introduced within a knitted fabric, e. g., for button holes, by binding off and re-casting on again ( horizontal ) or by knitting the fabrics on either side of a vertical edge separately.

Casting ( or " binding ") off loops the stitches across each other so they can be removed from the needle without unravelling the item.

Crochet hooks and a darning needle are often useful in binding off or in joining two knitted pieces edge-to-edge.

Production of cI leads to the binding of cI to the OR1 and OR2 sites in the P < sub > R </ sub > promoter, turning off cro and other early gene expression.

After the effects of the drug wear off, one might feel depressed because of the decreased probability of the neurotransmitter binding to a receptor.

Kinases are turned on or off by phosphorylation ( sometimes by the kinase itself-cis-phosphorylation / autophosphorylation ), by binding of activator proteins or inhibitor proteins, or small molecules, or by controlling their location in the cell relative to their substrates.

However, on November 14, 2009, the New York Times announced that " President Obama and other world leaders have decided to put off the difficult task of reaching a climate change agreement ... agreeing instead to make it the mission of the Copenhagen conference to reach a less specific " politically binding " agreement that would punt the most difficult issues into the future ".

In 1978 the bellicose Argentine dictatorship abrogated the binding Beagle Channel Arbitration and started the Operation Soberania in order to invade Chile but called off the operation a few hours later due to military and political reasons.

Sarah scares off Bonnie and Rochelle and defeats Nancy, binding her power to prevent her from doing harm.

The energy given off during either nuclear fusion or nuclear fission is the difference between the binding energies of the " fuel ", i. e., the initial nuclide ( s ), and the fission or fusion products.

The immobilized protein is purified and released from the beads by cleaving off the chitin binding domain.

The tightness of the binding meant that the circulation in the feet was faulty, and the circulation to the toes was almost cut off, so any injuries to the toes were unlikely to heal and were likely to gradually worsen and lead to infected toes and rotting flesh.

Regulatory proteins are often needed to be bound to a regulatory binding site to switch a gene on ( activator ) or to shut off a gene ( repressor ).

The library will gather and set aside their volumes which they want library bound, and then box and ship off these books to a library binding company.

Generally for this sort of a technique, histidine binding is titrated using pH instead of imidazole binding — at a high pH histidine binds to nickel or cobalt but at low pH (~ 6 for cobalt and ~ 4 for nickel ) histidine becomes protonated and is competed off of the metal ion.

Backcountry sleds, with the binding system and padding, may also be used for freestyle moves such as spins and flips off jumps and rail slides.

The SANB ( still a cultural association at the core ) risked having its funding from the Government of Canada cut off before it explained that the convention produced no consensus and was not binding.

We are the only Southern Hemisphere country with binding legal obligations under Kyoto and giants like China and India have got off scot free .”

Conversely, in the lungs, where oxygen concentration is high, binding of oxygen causes hemoglobin to release protons, which combine with bicarbonate to drive off carbon dioxide in exhalation.

If a large number of proteins bind to sites in a small volume such that there the fluorescence signal is dominated by the signal from bound proteins, and if this binding is all in a single state with an off rate k < sub > off </ sub >, then the fluorescence as a function of time is given by

Since this loop constitutes the " lid " that covers the top of the ligand binding site, this conformational difference highlights the difficulties in constructing homology models of other GPCRs based only on the rhodopsin structure.

Traditional quilting is a six-step process that includes: 1 ) selecting a pattern, fabrics and batting ; 2 ) measuring and cutting fabrics to the correct size to make blocks from the pattern ; 3 ) piecing ( sewing cut pieces of fabric together using a sewing machine or by hand to make blocks ) blocks together to make a finished " top "; 4 ) layering the quilt top with batting and backing, to make a " quilt sandwich "; 5 ) quilting by hand or machine through all layers of the quilt sandwich ; and 6 ) squaring up and trimming excess batting from the edges, machine sewing the binding to the front edges of the quilt and then hand-stitching the binding to the quilt backing.

If binding around a not fully convex, or square-edged object, arrange the knot so the overhand knot portion is stretched across a convex portion, or a corner, with the riding turn squarely on top of it.

Four binding post s depicted at the top.

The guitar is a modified Telecaster Thinline with laminated top of figured maple, set neck with deep carved heel, birdseye maple fingerboard with 22 jumbo frets, ivoroid pickguard and binding, gold hardware, abalone Tuff Dog Tele peghead inlay, 2-Colour Sunburst finish and a pair of Fender Texas Special Tele single-coil pickups with custom-wired 4-way pickup switching.

Legal pads usually have a gum binding at the top as opposed to a spiral or stitched binding.

* 000-1: Slightly smaller in all dimensions than a dreadnought guitar ( the " standard " acoustic guitar ), solid Sitka spruce top, solid mahogany back, laminated mahogany sides, tortoiseshell binding, rosewood fingerboard.

* D-28: Dreadnought guitar, solid Sitka spruce top, solid East Indian rosewood ( Brazilian rosewood before 1969 ) back and sides, ebony fingerboard, black and white binding and ornamentation with 5 / 16 " non-scalloped braces.

* NIS ( Nordic Integrated System ) is the latest incarnation of NNN, unveiled by Rossignol, Madshus, Rottefella, and Alpina in January 2005 ; The new system features integrated binding plate on the top of the ski to which the bindings attach, allowing easy installation of bindings and even adjusting them on-the-fly depending on weather and snow conditions.

This would only work if the sole was held very firmly down on the pins, so the binding also introduced a metal clip that was forced down onto the top of the sole of the boot, forcing it onto the pins.

A system for estimating the prion-binding capacity of soil on farms using simple soil analysis may allow an estimate of the prion risk in the environment, and whether prion binding by the use of soil amendments or top dressings may help to mitigate the infectious prions.

The SG also lacks the carved maple top and body binding of the Les Paul.

The colors of the coat of arms and other elements of the state flag shall be the following: Husbandman, trousers of gray brown, shirt of red, hat and hilling hoe of brown ; rifleman, suit of green, binding, bag and leggings of buff, hat of brown, powder flask and feather of gray ; shield, frame of shaded yellow, top panel of orange, center panel of blue, lower panel of white, ox of red brown, grass and corn of green, wheat and branches underfoot of yellow, heraldic wreath to be blue and silver ( twisted ); ship under full sail to have a dark hull and white sails ; date, December 7, 1787, to be white ; cord and tassels to be blue and gold.

The binding was removed and various nicks and dents in the top were repaired.

CREB ( top ) is a transcription factor capable of binding DNA ( bottom ) and regulating gene expression.

It featured a carved maple top with hand scraped edges and cream binding, a set-neck maple neck ( bolt-on on some models ), a sleek mahogany body ( many Showmaster guitars are made from basswood or alder ; later models such as the Showmaster Elite, employ more exotic timbres such as lacewood and spalted maple for the top and back ), HSS or HH pickup configurations which consisted of Seymour Duncan ' 59 Trembucker humbucking pickups coupled with a pair of Fender Custom Shop Fat ' 50s single-coils.

The main distinguishing feature of Fender Showmasters — with the exception of the Flat Head — from other superstrats is the luxurious carved ( quilted and flamed ) maple top with the hand-scraped edges and cream binding.

First, the attachment of the voulge blade to the shaft was usually done by binding the lower two thirds of the blade to the side of the pole ; the glaive would often have a socket built into the blade itself and was mounted on top of the pole.