Noradrenergic and specific serotonergic antidepressants ( NaSSAs ) form a newer class of antidepressants which purportedly work to increase norepinephrine ( noradrenaline ) and serotonin neurotransmission by blocking presynaptic alpha-2 adrenergic receptors while at the same time blocking certain serotonin receptors.

It is proposed that DMT and other endogenous hallucinogens mediate their neurological abilities by acting as neurotransmitters at a sub class of the trace amine receptors ; a group of receptors found in the CNS where DMT and other hallucinogens have been shown to have activity.

Of class A GPCRs, over half of these are predicted to encode olfactory receptors while the remaining receptors are liganded by known endogenous compounds or are classified as orphan receptors.

Ligands may also bind elsewhere, however, as is the case for bulkier ligands ( e. g., proteins or large peptides ), which instead interact with the extracellular loops, or, as illustrated by the class C metabotropic glutamate receptors ( mGluRs ), the N-terminal tail.

Rather, it depends on the class of chemical receptors present on the postsynaptic neuron.

However, neighboring target neurons called ON bipolar cells are instead inhibited by glutamate, because they lack the typical ionotropic glutamate receptors and instead express a class of inhibitory metabotropic glutamate receptors.

Valerian extracts appear to have some affinity for the GABA < sub > A </ sub > receptor, a class of receptors on which benzodiazepines are known to act .< ref >

A new class of medication, the " vaptan " drugs has been specifically developed to inhibit the action of vasopressin on its receptors ( V1A, V1B, and V2 ).

Cannabinoids are a class of diverse chemical compounds that activate cannabinoid receptors.

The CD4 receptors borne by naive helper T cells ligate MHC class II while the epitope — within the MHC class II molecule — imprints the T cell receptor ( TCR ) of the naive helper T cell, memorizing that epitope.

Regular cells express MHC class 1 and therefore are recognised by KIR receptors and NK cell killing is inhibited.

These inhibitory receptors recognize MHC class I alleles, which could explain why NK cells kill cells possessing low levels of MHC class I molecules.

* Adrenergic Receptor, a class of G protein-coupled receptors

The adrenergic receptors ( or adrenoceptors ) are a class of metabotropic G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine ( noradrenaline ) and epinephrine ( adrenaline ).

* Phenylaminotetralin, class of organic compounds, some of which have novel activity at histamine receptors

This class of receptors includes the metabotropic glutamate receptors, muscarinic acetylcholine receptors, GABA < sub > B </ sub > receptors, and most serotonin receptors, as well as receptors for norepinephrine, epinephrine, histamine, dopamine, neuropeptides and endocannabinoids.

Monogamy is the vice from which the abjectly fearful middle class continue to suffer, whereas the beatnik has the courage to break out of that prison of respectability.

And it is precisely in this poorer economic class that one finds, and has always found, the most racial friction.

Was it supposed, perchance, that A & M ( vocational training, that is ) was quite sufficient for the immigrant class which flooded that part of the New England world in the post-Civil War period, the immigrants having been brought in from Southern Europe, to work in the mills, to make up for the labor shortage caused by migration to the West??

By virtue of his self-reliance, his individualism and his freedom from external restraint, the private eye is a perfect embodiment of the middle class conception of liberty, which amounts to doing what you please and let the devil take the hindmost.

At the same time, because the personal code of the detective coincides with the legal dictates of his society, because he likes to catch criminals, he is in middle class eyes a virtuous man.

Since a civilizational crisis involves also a crisis in private interests and in the ruling class, reaction is normally found among those who feel themselves to be among the ruling class.

The concept of labor as a special class is outmoded, and in the task confronting America as bastion of the free world, labor must learn to put the national interest first if it is itself to survive.

The soldiers themselves cannot stage a successful rebellion, it is assumed: but will their discontent spread to the officer class??

Therefore, under our longstanding allocation rules, on some of these channels no station other than the dominant ( class 1 ) -- A ) station is permitted to operate at night, so that the 1, -- A station can render service, interference free, wherever it can be received.

Such additional daytime class 2, assignments are appropriate if optimum use is to be made of these frequencies, and the Commission has over the years made a large number of them.

Staley Hanover ( Knight Dream-Sweetmite Hanover ) is a little on the small side but a very compact colt and looks like one to stand training and many future battles with colts in his class.

Consultation with architects, clients, real estate men, fabric houses and furniture companies is essential to the proper development of class problems just as in actual work.

As is well known, detergent actives belong to the chemical class consisting of moderately high molecular weight and highly polar molecules which exhibit the property of forming micelles in solution.

This is particularly true of highly charged ions, especially those ions which fall into the class of polyelectrolytes.

The class of the congruence is Af, since an arbitrary plane meets **zg in K points.

The congruence of its secants is therefore of order Af and class Af.

A final class of exceptional lines is identifiable from the following considerations: Since no two generators of Af can intersect, it follows that their image curves can have no free intersections.

Therefore, the congruence of its secants, that is the image of a general plane field of lines, is of order Af and class Af.

Finally, the image of a general bundle of lines is a congruence whose order is the order of the congruence of invariant lines, namely Af and whose class is the order of the image congruence of a general plane field of lines, namely Af.

Another great danger is that the emerging middle class will feel itself increasingly alienated from the political leaders who still justify their dominance by reference to the struggle for independence or the early phase of nationalism.

The class of grammar-based codes are recently noticed because they can extremely compress highly repetitive text, for instance, biological data collection of same or related species, huge versioned document collection, internet archives, etc.

In the past decade, Hobart International Airport received a huge upgrade, with the airport now being a first class airport facility.

The story about a poor bootblack's rise to middle class respectability was a huge success.

Small farms in this situation often went bankrupt and were bought up by the wealthy upper class, forming huge private estates.

This system had a huge influence on both society and culture in Imperial China and was directly responsible for the creation of a class of scholar-bureaucrats irrespective of their family pedigree.

In the late nineteenth century, the ruling class having been granted huge Jagirs became rich and started constructing huge mansions with sprawling lawns.

After an interpretive dance to Cyndi Lauper's hit " Time After Time " that receives huge applause from the rest of the class, he escorts them to his helicopter and the three prepare to fly away together.

However, it seems that much of the startup time is sometimes due to IO-bound operations rather than JIT compilation ( for example, the rt. jar class data file for the Java Virtual Machine is 40 MB and the JVM must seek a lot of data in this contextually huge file ).

< blockquote class =" toccolours " style =" text-align: left ; width: 27 %; float: right ; margin: 10px 10px 5px 5px ; padding: 10px ; display: table ;">" In my naïvety, I thought people who were in rock ' n ' roll bands were great artists, and it was a huge shock to the system to realise that they weren't, that they didn't even aspire to be, really.

Lucy's focus shifted somewhat to class struggles around poverty and unemployment, and she organized the Chicago Hunger Demonstrations in January 1915, which pushed the American Federation of Labor, the Socialist Party, and Jane Addams ' Hull House to participate in a huge demonstration on February 12.

The massive tourism, triggered by the welfare politics of Perón and the surge of the middle class marked a huge growth in the city's economy.

The aliens in the school included Gilda Gossip, the girl with the big mouth or mouths, Booey Bubblehead, who has a bubble for a head and is absent-minded, Milo De Venus, the six armed class president, Beef and the Bonk Bunch who bully Doyle ( and just about every student at Galaxy High ), and The Creep, a small alien who resembled something between a very fat cherub and a marshmallow and had a huge crush on Aimee which would often reveal itself as he serenaded like a Las Vegas lounge singer.

In the Napoleonic period Britain built huge numbers of brig sloops of the Cruizer class ( 18 guns ) and the Cherokee class ( 10 guns ).

Their middle class status contrasted with the huge estate of his paternal grandparents in Staffordshire.

In June 2012 Denham publicly admitted that Labour knew immigration was causing huge problems for working class people in England as early as 2005.

The PRR decapod, class I1s, was unlike the Russian decapod ; it was huge, taking advantage of the PRR's heavy trackage and high axle loading, with a fat, free-steaming boiler that earned the type the nickname of ' Hippos ' on the PRR.

The class covers a huge variety of professions, from knights to bandits.

ProNites are especially a huge success with a large number of top class artists coming and performing on one stage.

Remembering the days of 1985 Nagarjuna, another big star of Telugu film industry says " by the time i entered films, he was already a very big star-a man who had mass appeal and a huge fan following .. without absolutely anybody's backing, he made it to the top in the telugu film industry becoming the most popular hero-admired by both the masses and the class audience.

* its huge trading volume representing the largest asset class in the world leading to high liquidity ;

Orthogastropoda was a major taxonomic grouping of snails and slugs, an extremely large subclass within the huge class Gastropoda according to the older taxonomy of the Gastropoda ( Ponder & Lindberg, 1997 ).

Kevin J. Flynn's book The Silent Brotherhood described The Spotlight as regularly featuring " articles on such topics as Bible analysis, taxes and fighting the IRS, bankers and how they bleed the middle class, and how the nation is manipulated by the dreaded Trilateral Commission and Council on Foreign Relations ", adding " the paper attracted a huge diversity of readers ".