Topoisomerases are essential enzymes that maintain the topology of DNA.

Topoisomerases ( type I:, type II: ) are enzymes that regulate the overwinding or underwinding of DNA.

Topoisomerases are isomerase enzymes that act on the topology of DNA.

Topoisomerases catalyze and guide the unknotting or unkinking of DNA by creating transient breaks in the DNA using a conserved Tyrosine as the catalytic residue.

Topoisomerases introduce both single-and double-strand breaks in the course of changing the DNA's state of supercoiling, which is especially common in regions near an open replication fork.

** Topoisomerases reduce supercoiling of DNA in the cell.

`` I can fix him something later in the afternoon when we get home ''.

`` If you can fix it up with the undertaker '', returned the politician, `` it's all right with me ''.

that can be combined together to accomplish a task, much as one might use multiple hand tools to fix a physical object.

But these synonyms can at least help us to get a fix on the concept we are talking about.

They can be used to catch crackers or fix vulnerabilities.

Blending is most easily done with a medium that does not immediately fix itself, such as graphite, chalk, or charcoal, although freshly applied ink can be smudged, wet or dry, for some effects.

Some women who identified as lesbian following colonization have been submitted to the curative effort of rape in the mindset that sex with men can fix lesbianism.

If it is not possible to fix the broken ligament, other procedures such as the Brunelli procedure can correct the instability.

By determining the intersection of the two hyperbolic curves identified by this method, a geographic fix can be determined.

Maatkit can be used to prove replication is working correctly, fix corrupted data, automate repetitive tasks, and speed up servers.

As some microorganisms can fix nitrogen, they are a vital part of the nitrogen cycle, and recent studies indicate that airborne microbes may play a role in precipitation and weather.

Standards ( Ethernet, for example ) can fix the size of an MTU ; or systems ( such as point-to-point serial links ) may decide MTU at connect time.

For a nonzero vector of finite norm in, one can assume that is nonzero, or to fix ideas.

Nitrogen fixation by cyanobacteria in coral reefs can fix twice the amount of nitrogen than on land — around 1. 8 kg of nitrogen is fixed per hectare per day.

Plasmids can also provide bacteria with the ability to fix elemental nitrogen or to degrade recalcitrant organic compounds that provide an advantage when nutrients are scarce.

* It can induce growth arrest by holding the cell cycle at the G < sub > 1 </ sub >/ S regulation point on DNA damage recognition ( if it holds the cell here for long enough, the DNA repair proteins will have time to fix the damage and the cell will be allowed to continue the cell cycle ).

For a given choice of those parameters, one could make sense of the theory, but since we can never do infinitely many experiments to fix the values of every parameter, we do not have a meaningful physical theory:

More people can review the details of such algorithms, identify flaws, and fix the flaws sooner.

If the management ethos is to reward the number of bugs fixed, then some developers may quickly write sloppy code knowing they can fix the bugs later and be rewarded for it, whereas careful, perhaps " slower " developers do not get rewarded for the bugs that were never there.

# Lack of an open standard can also become problematic for the customers, as in case of the original vendor's inability to fix a certain problem that is an artifact of technical limitations in the original product.

A radio fix on two stations can be found in exactly the same way.

This allows the player to control squares of both colors, allows the bishop to move freely among the pawns, and helps fix enemy pawns on squares on which they can be attacked by the bishop.

* If we fix a homomorphism of abelian groups, we can consider the category consisting of all pairs where is an abelian group and is a group homomorphism with.

# Other processes: In addition, the formation of NO from N < sub > 2 </ sub > and O < sub > 2 </ sub > due to photons and especially lightning, can fix nitrogen.

A patch is a file that can be loaded to fix problems or provide extensions to a particular version of a system.

And no messages can be transmitted on these circuits until senders and receivers authenticate in advance, by special codes, that the messages actually come from their purported sources.

We have staved off a war and, since our behavior has involved all these elements, we can only keep adding to our ritual without daring to abandon any part of it, since we have not the slightest notion which parts are effective.

Underlying these conceptions of mimesis are certain presuppositions concerning the nature of primary human experience which require some exposition before the main argument can proceed.

We feel uncomfortable at being bossed by a corporation or a union or a television set, but until we have some knowledge about these phenomena and what they are doing to us, we can hardly learn to control them.

The men who speculate on these institutions have, for the most part, come to at least one common conclusion: that many of the great enterprises and associations around which our democracy is formed are in themselves autocratic in nature, and possessed of power which can be used to frustrate the citizen who is trying to assert his individuality in the modern world ''.

The Axioms required to make the theoretical machinery operate are set out tersely and powerfully, so that all permissible operations within the theory can be traced rigorously back to these axioms, rules, and primitive notions.

But when these expectations are once too often ground into the dust, innocence can falter, since its strength is according to the strength of him who possesses it.

As a nation we can successfully pursue these objectives only from a position of broadly based strength.

A contrast of the scripture reading of, let us say, St. Augustine, John Bunyan, and Thomas Jefferson, all three of whom found in such study a real source of enlightenment, can tell us a great deal about these three men and the age that each represented and helped bring to conscious expression.

Within the fixed frame of these aspirations, they can afford to place a high value on the expressive and people-oriented aspects of occupation and to minimize the instrumental-reward values of power, prestige, and wealth.

How effectively these warnings can be presented is seen in Pohl and Kornbluth's The Space Merchants, Vonnegut's Player Piano and Wyndham's Re-Birth.

Perhaps the moralities of world law are not advanced by stealing American diplomatic papers and planes, but the Kennedy administration can always file a demurrer to the effect that, but for its own incompetence in protecting American interests, these things would not happen.

After all, where else can the public see a wagon these days??

The demand for these lots can be met for some time to come.

Visitors are welcome to come see what these dedicated mothers can do.

On these they feel they can rely.

He merely said, `` Any good decorator these days can make you a tasteful home ''.

You can do anything with these dumb fucks if you know how.

`` See, Argiento, if you control the way these folds are bunched, like this, or made to flow, you can enrich the body attitudes.

It all began on an autumn afternoon -- and who, after all these centuries, can describe the fineness of an autumn day??

In several significant cases, such as India, a decade of concentrated effort can launch these countries into a stage in which they can carry forward their own economic and social progress with little or no government-to-government assistance.

and now, therefore, do I, John A. Notte, Jr., governor of the State of Rhode Island and Providence Plantations, proclaim the week of april 29th to may 7th, 1961, as Rhode Island Heritage Week, advising our citizens that throughout this week many historic houses and beautiful gardens will be open to visitors as well as industrial plants, craft shops, museums and libraries and I earnestly urge all to take advantage of these opportunities to see as many of these places as they can during this outstanding week.

A study of the hydrogen line profiles indicates that a measurement of these profiles can be used to calculate a temperature for the arc plasma that is reliable to about Af percent.