Upon antigen binding, they cluster in large patches, which can exceed 1 micrometer in diameter, on lipid rafts that isolate the BCRs from most other cell signaling receptors.

Upon its confirmation, the plan becomes binding and identifies the treatment of debts and operations of the business for the duration of the plan.

Upon binding, the complex is taken into the cell via receptor-mediated endocytosis.

Upon GTP binding, both G < sub > α </ sub >- GTP and G < sub > βγ </ sub > separate from both the receptor and from each other.

Upon binding, the ligand induces a change in the conformation of the inside part of the receptor.

Upon bombardment with slow neutrons, its uranium-235 isotope will most of the time divide into two smaller nuclei, releasing nuclear binding energy and more neutrons.

Upon steroid binding, the androgen receptor ( AR ) undergoes a conformational change and releases heat shock proteins ( hsps ).

Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A.

Upon recruitment of U2 snRNP, the branch binding protein SF1 in the commitment complex is displaced since the binding site of U2 snRNA and SF1 are mutually exclusive events.

Upon steroid binding, many kinds of steroid receptor dimerize: Two receptor subunits join together to form one functional DNA-binding unit that can enter the cell nucleus.

Upon injection of the sample, solute molecules will exchange with the buffer ions as each competes for the binding sites on the resin.

Upon hormone binding, the receptor can initiate multiple signaling pathways which ultimately lead to changes in the behaviour of the target cells.

# Upon strong binding, myosin and actin undergo an isomerization ( myosin rotates at the myosin-actin interface ) extending an extensible region in the neck of the myosin head.

Upon drug binding, receptors can elicit their normal action ( agonist ), blocked action ( antagonist ), or even action opposite to normal ( inverse agonist ).

Upon binding to clots, or to the cell surface, plasminogen adopts an open form that can be converted into active plasmin by a variety of enzymes, including tissue plasminogen activator ( tPA ), urokinase plasminogen activator ( uPA ), kallikrein, and factor XII ( Hageman factor ).

Upon binding of gp120 to the CD4 receptor and coreceptor, a number of conformational changes in the structure leads to the dissociation of gp120 and to the exposure of gp41 and at the same time to the fusion peptide sequence located at the N-terminus of gp41 to anchor into the host cell.

Upon binding to DNA ( the " Gyrase-DNA " state ), there is a competition between DNA wrapping and dissociation, where increasing DNA tension increases the probability of dissociation.

Upon activation by PDGF, these receptors dimerise, and are " switched on " by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway.

Upon entering as a student, each man pledges that he will not lie, cheat, steal, nor tolerate those who do ; this pledge is binding for life.

Upon binding by the hormone the receptor undergoes a conformational change, the hsp come off, and the receptor together with the bound hormone enter the nucleus to act upon transcription.

Upon ATP binding and hydrolysis, AAA enzymes undergo conformational changes in the AAA-domains as well as in the N-domains.

Upon binding to Apo-CII and lipid in the lipoprotein, the C-terminal domain presents the lipid substrate to the lid region.

Upon binding with cGMP PDE, RGS9-1 GAP activity is enhanced.

Upon reusing these healthy chickens, Pasteur discovered he could not infect them, even with fresh bacteria ; the weakened bacteria had caused the chickens to become immune to the disease, though they had caused only mild symptoms.

Upon exposure to gliadin, the enzyme tissue transglutaminase modifies the protein, and the immune system cross-reacts with the bowel tissue, causing an inflammatory reaction.

Upon challenge with endotoxin, these cells form a broad spectrum of immune mediators such as cytokines, nitric oxide, and eicosanoids.

Upon examining the upper respiratory tissue from mice exposed to both bacteria, an extraordinarily large number of neutrophil immune cells were found.

Upon examining the upper respiratory tissue from mice exposed to both bacteria species, an extraordinarily large number of neutrophils ( immune cells ) was found.

Upon the isomorphic substitution of metal atoms close in properties crystalline complexes of variable composition are formed.

Upon the expiration of a period deemed adequate for demonstration purposes for each plant, but not to exceed such twelve-year period, the Secretary shall proceed as promptly as practicable to dispose of any plants so constructed by sale to the highest bidder, or as may otherwise be directed by Act of Congress.

Choreographed by Mr. Nagrin, the work filled the second half of a program that also offered the first New York showing of Miss Tamiris' `` Once Upon A Time '' as well as her `` Women's Song '' and Mr. Nagrin's `` Indeterminate Figure ''.

* Upon his adoption by Caesar, he took Caesar's name and become Gaius Julius Caesar Octavianus in accordance with Roman adoption naming standards.

Upon his assumption into immortality on Olympus, Heracles is given ambrosia by Athena, while the hero Tydeus is denied the same thing when the goddess discovers him eating human brains.

A Fire Upon the Deep is a science fiction novel by American writer Vernor Vinge, a space opera involving superhuman intelligences, aliens, variable physics, space battles, love, betrayal, genocide, and a conversation medium resembling Usenet.

A Fire Upon the Deep won the Hugo Award in 1993 ( tied with Doomsday Book by Connie Willis ).

A Fire Upon the Deep shared the 1993 Hugo Award for Best Novel with Doomsday Book, by Connie Willis.

Upon landing in al-Andalus, Abd al-Rahman was greeted by clients Abu Uthman and Ibn Khalid and an escort of 300 cavalry.

Chapter 17 of William Bates ' 1920 book Perfect Sight Without Glasses, in which the author argues that observation of the sun is beneficial to those with poor vision, includes a figure of somebody " Focussing the Rays of the Sun Upon the Eye of a Patient by Means of a Burning Glass.

Upon sporulation, B. thuringiensis forms crystals of proteinaceous insecticidal δ-endotoxins ( called crystal proteins or Cry proteins ), which are encoded by cry genes.

Upon the return from Babylonia and the restoration of the Temple, YHWH will once again dwell in the new Temple as he had in the Temple built by Solomon.

A Married Women ( Restraint Upon Anticipation ) Act was passed in 1949 “ to equalise, to render inoperative any restrictions upon anticipation or alienation attached to the enjoyment of property by a woman ,” while the Married Women ( Maintenance ) Act of 1949 was enacted with the intention of improving the adequacy and duration of financial benefits for married women.

Upon activating the amulet, the player is informed of his / her past by his / her dead father, after which the player is transported to the town of Crossroads, and Part I ends.

Upon Mercer's departure, Verne Lundquist joined the network, and became their play-by-play announcer by 1977, serving eight years in that capacity before handing those chores permanently over to Brad Sham, who joined the network in 1977 as the color analyst and occasional fill-in for Lundquist.

Upon completion of his Presidential term, his commission was reactivated by Congress and Eisenhower again was commissioned a five-star general in the United States Army.

Upon his accession, Domitian revalued the Roman currency by increasing the silver content of the denarius by 12 %.

Upon the death of Domitian, Nerva was proclaimed Emperor by the Roman Senate | Senate.

Upon disconnecting, the IP address is returned to the pool for use by another computer.

Roger Ebert approves of the use of the label in unsuccessful films that had been tampered with by studio executives, such as Sergio Leone's original cut of Once Upon a Time in America, and the moderately successful theatrical version of Daredevil, which were altered by studio interference for their theatrical release.

Upon orbital insertion around Jupiter, however, David Bowman is confronted with a huge, black featureless monolith with the exact proportions of 1 by 4 by 9 ( the squares of the first three positive integers ).

Upon Ivan's death, he was succeeded by his simple-minded son Feodor.