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Upon antigen binding, they cluster in large patches, which can exceed 1 micrometer in diameter, on lipid rafts that isolate the BCRs from most other cell signaling receptors.
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Upon and antigen
Upon subsequent encounters with a given antigen, memory T cells are re-activated using the same TCR pathways.
Upon immunisation with an antigen, more of these receptors are formed, and they are then shed from the cells to circulate in the blood.
Upon activation they rapidly uptake MHC class I / II proteins and quickly become efficient antigen presenters.
Upon a later encounter with the same antigen, these memory cells quickly differentiate into effector cells, dramatically shortening the time required to mount an effective response.
Upon activation, B cells produce antibodies, each of which recognizes a unique antigen, and neutralize specific pathogens.
Upon interaction with a previously encountered antigen, the appropriate memory cells are selected and activated.
Upon and binding
Upon its confirmation, the plan becomes binding and identifies the treatment of debts and operations of the business for the duration of the plan.
Upon binding, the complex is taken into the cell via receptor-mediated endocytosis.
Upon GTP binding, both G < sub > α </ sub >- GTP and G < sub > βγ </ sub > separate from both the receptor and from each other.
Upon binding, the ligand induces a change in the conformation of the inside part of the receptor.
Upon bombardment with slow neutrons, its uranium-235 isotope will most of the time divide into two smaller nuclei, releasing nuclear binding energy and more neutrons.
Upon steroid binding, the androgen receptor ( AR ) undergoes a conformational change and releases heat shock proteins ( hsps ).
Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A.
Upon recruitment of U2 snRNP, the branch binding protein SF1 in the commitment complex is displaced since the binding site of U2 snRNA and SF1 are mutually exclusive events.
Upon steroid binding, many kinds of steroid receptor dimerize: Two receptor subunits join together to form one functional DNA-binding unit that can enter the cell nucleus.
Upon injection of the sample, solute molecules will exchange with the buffer ions as each competes for the binding sites on the resin.
Upon hormone binding, the receptor can initiate multiple signaling pathways which ultimately lead to changes in the behaviour of the target cells.
# Upon strong binding, myosin and actin undergo an isomerization ( myosin rotates at the myosin-actin interface ) extending an extensible region in the neck of the myosin head.
Upon drug binding, receptors can elicit their normal action ( agonist ), blocked action ( antagonist ), or even action opposite to normal ( inverse agonist ).
Upon binding to clots, or to the cell surface, plasminogen adopts an open form that can be converted into active plasmin by a variety of enzymes, including tissue plasminogen activator ( tPA ), urokinase plasminogen activator ( uPA ), kallikrein, and factor XII ( Hageman factor ).
Upon binding of gp120 to the CD4 receptor and coreceptor, a number of conformational changes in the structure leads to the dissociation of gp120 and to the exposure of gp41 and at the same time to the fusion peptide sequence located at the N-terminus of gp41 to anchor into the host cell.
Upon binding to DNA ( the " Gyrase-DNA " state ), there is a competition between DNA wrapping and dissociation, where increasing DNA tension increases the probability of dissociation.
Upon activation by PDGF, these receptors dimerise, and are " switched on " by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway.
Upon entering as a student, each man pledges that he will not lie, cheat, steal, nor tolerate those who do ; this pledge is binding for life.
Upon binding by the hormone the receptor undergoes a conformational change, the hsp come off, and the receptor together with the bound hormone enter the nucleus to act upon transcription.
Upon ATP binding and hydrolysis, AAA enzymes undergo conformational changes in the AAA-domains as well as in the N-domains.
Upon the binding of C1 to immune complexes by virtue of the affinity of C1q for immunoglobulins ( to be specific, IgM and IgG ), the controlling action of C1-In is overcome, and C1q effects activation of C1r2s2.
Upon binding to Apo-CII and lipid in the lipoprotein, the C-terminal domain presents the lipid substrate to the lid region.
Upon binding with cGMP PDE, RGS9-1 GAP activity is enhanced.
Upon and they
Upon arriving at the rim of North Ray Crater, they were away from the LM.
“ Upon her children I will have no pity, because they are children of whoredom ” ( Hosea 2: 4 ).
Upon his ejection, Mr. Sianis uttered, " The Cubs, they ain't gonna win no more.
Upon reaching Salzburg, however, they found that he was not available and, disillusioned, returned to the United States after spending only 15 days of their planned three years in Europe.
Upon arriving at Archduke Franz Ferdinand's country seat, château Konopiště, on a semi-official visit, they promptly proceeded to do away with one of the Austro-Hungarian heir presumptive's priceless golden pheasants, thereby almost causing an international incident.
Upon further examination, it was concluded that if the marks were bite marks, they did not match the teeth of any of the three convicted.
Upon observation, researchers discovered users unconsciously assuming ELIZA's questions implied interest and emotional involvement in the topics discussed, even when they consciously knew that ELIZA did not simulate emotion.
Upon his arrival in Hollywood, Lang joined the MGM studio and directed the crime drama Fury, starring Spencer Tracy as a man wrongly accused of a crime and then attacked by lynch mob who burn down the jail where he is awaiting trial and it is assumed they killed him in the flames, but did not.
Upon reaching the Cap Rock section of the park, they attempted to cremate Parsons ' corpse by pouring five gallons of gasoline into the open coffin and throwing a lit match inside.
" Upon completing, they may stop collecting, expand the collection to include related items, or begin an entirely new collection.
Upon his return to the astronaut corps in Houston, he played a key role in training Apollo crews to be geologic observers when they were in lunar orbit and competent geologic field workers when they were on the lunar surface.
Upon examining DNA from the moa, they believe that the kiwi is more closely related to its Australian cousins.
Upon reusing these healthy chickens, Pasteur discovered he could not infect them, even with fresh bacteria ; the weakened bacteria had caused the chickens to become immune to the disease, though they had caused only mild symptoms.
Upon gaining 75 % pass marks, they can proceed to the next level.
Upon seeing a chemist's shop, Cleese pondered whether the shop would sell cheese, to which Chapman responded that if they did it would be medicinal cheese and that Cleese would need a prescription to buy some.
Upon arriving in Diriyah, Muhammad bin Saud and Muhammad ibn ʿAbd al-Wahhab concluded an agreement that, together, they would bring the Arabs of the peninsula back to the " true " principles of Islam as they saw it.
Upon Escher's death, his three sons dissolved the Foundation, and they became partners in the ownership of the art works.
Upon the Spaniards ' arrival to the Philippines, they were dismayed to find such a strong Muslim presence on the island, having just expelled the Moors from Spain after centuries of fighting.
Upon leaving the White House, the couple returned to California, where they purchased a home in the wealthy East Gate Old Bel Air neighborhood of Bel Air, Los Angeles, dividing their time between Bel Air and the Reagan Ranch in Santa Barbara, California ; Ronald and Nancy regularly attended Bel Air Presbyterian Church as well.
Upon their arrival in Puerto Rico, they were received by 18, 000 people.
* Upon calling the athlete's name, they have sixty seconds to commence the throwing motion.
Upon activation, they assign proteins to specific membrane subdomains where they participate in signaling.
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