When studied outside the cell, the slowest folding proteins require many minutes or hours to fold primarily due to proline isomerization, and must pass through a number of intermediate states, like checkpoints, before the process is complete.

When this leucine is replaced with a proline residue the alpha helix is broken, introducing a conformational change to the C-Terminal domain, separating it from the N-Terminal domain enough to promote higher activity of the protein.

When Heidegger and Sartre speak of a contrast between being and existence, they may be right, I don't know, but their language is too philosophical for me.

When they express themselves it is incandescent hatred that shines forth, the rage of repudiation, the ecstasy of negation.

When I try to work out my reasons for feeling that this passage is of critical significance, I come up with the following ideas, which I shall express very briefly here and revert to in a later essay.

When the proprietor dies, the establishment should become a corporation until it is either acquired by another proprietor or the government decides to drop it.

When the reactionary response is thus bolstered by an intellectual defense, the characteristics of that defense are explicable only in terms of the basic attitudes of unanalyzed reaction.

When I take over Taliesin, the first thing I'll do is fire you ''.

When someone in the audience rose and asked how does it feel to be a celebrity, Carl said, `` A celebrity is a fellow who eats celery with celerity ''.

When decision makers act within this frame they determine whether a claim put forward in the name of religion is to be accepted by the larger community as appropriate to religion.

When we consider the disorganized state of the world community, and the legacy of predispositions adversely directed against all who are identified as Jews, it is obvious that the struggle for the minds and muscles of men needs to be prosecuted with increasing vigor and skill.

When we turn to Aristotle's ideas on the moral measure of literature, it is at once apparent that he is at times equally concerned about the influence of the art.

When their faith in civil liberties is tested against strong pressures of social expediency in specific issues, e.g., suppression of `` dangerous ideas '', many waver and give in.

There is, of course, nothing new about dystopias, for they belong to a literary tradition which, including also the closely related satiric utopias, stretches from at least as far back as the eighteenth century and Swift's Gulliver's Travels to the twentieth century and Zamiatin's We, Capek's War With The Newts, Huxley's Brave New World, E. M. Forster's `` The Machine Stops '', C. S. Lewis's That Hideous Strength, and Orwell's Nineteen Eighty-Four, and which in science fiction is represented before the present deluge as early as Wells's trilogy, The Time Machine, `` A Story Of The Days To Come '', and When The Sleeper Wakes, and as recently as Jack Williamson's `` With Folded Hands '' ( 1947 ), the classic story of men replaced by their own robots.

When I first came across Samuel Johnson's pronouncement, `` the remedy for the ills of life is palliative rather than radical '', it seemed to me to sum up the profoundest of political and social truths.

When all else fails, it is argued that open sessions slow down governmental operations.

When a person has thoughtlessly or deliberately caused us pain or hardship it is not always easy to say, `` Just forget it ''.

When a person meets God's requirements for the experience of forgiveness he is forgiven.

When I hold my son he stiffens his whole body in my arms until he is as straight and stiff as a board.

When different colors are used, she is just as likely to color trees purple, hair green, etc..

When we become firm enough to stand for those ideals which we know to be right, when we become hard enough to refuse to aid nations which do not permit self-determination, when we become strong enough to resist any more drifts towards socialism in our own Nation, when we recognize that our enemy is Communism not war, and when we realize that concessions to Communists do not insure peace or freedom, then, and only then will we no longer be `` soft ''.

When one powerful nation strives to emulate the success of another, it is only natural.

When a man is laid to rest, he is entitled to stay put.

When I talked to Ching about it, he said, Everyone can learn, if he is not a Reactionary or lazy.

When, during his discourses, he recounts his experiences as a young aspirant, he regularly uses the phrase " When I was an unenlightened bodhisatta ..." The term therefore connotes a being who is " bound for enlightenment ", in other words, a person whose aim is to become fully enlightened.

When a principle becomes customary law is not clear cut and many arguments are put forward by states not wishing to be bound.

When Loki, god of mischief and strife, murdered Baldr, god of beauty and light, he was punished by being bound in a cave with a poisonous serpent placed above his head dripping venom.

When the group of covalently bound atoms bears a net charge, the group is referred to more properly as a polyatomic ion or a complex ion.

When the gods knew that Fenrir was fully bound, they took a cord called Gelgja ( Old Norse " fetter ") hanging from Gleipnir, inserted the cord through a large stone slab called Gjöll ( Old Norse " scream "), and the gods fastened the stone slab deep into the ground.

When his woman dies, he seeks another woman ; to woman he is bound.

When oxygen is not bound, a very weakly bonded water molecule fills the site, forming a distorted octahedron.

When using delayed evaluation, an expression is not evaluated as soon as it gets bound to a variable, but when the evaluator is forced to produce the expression's value.

When merging two lists of length m, there is a lower bound of 2m − 1 comparisons required in the worst case.

The emphasis on the salvific nature of the Resurrection continued in Christian theology in the next centuries, e. g., in the 8th century Saint John of Damascus wrote that: "... When he had freed those who were bound from the beginning of time, Christ returned again from among the dead, having opened for us the way to resurrection " and Christian iconography of the ensuing years represented that concept.

When his woman dies, he seeks another woman ; to woman he is bound.

When determining the legal obligations of states, one party to the original treaty and one a party to the amended treaty, the states will only be bound by the terms they both agreed upon.

When the gods saw that Fenrir was bound they all rejoiced, except Tyr, who had his right hand bitten off by the wolf.

When Lyudmila Shestakova, the sister of Mikhail Glinka, learned of Mussorgsky's plans, she presented him with a volume of Pushkin's dramatic works, interleaved with blank pages and bound, and using this Mussorgsky began work in October 1868 preparing his own libretto.

When the binary encountered Neptune, it interacted in such a way that orbital energy was transferred from Triton to its companion ; the latter was expelled, while Triton became bound to Neptune.

When he heard their beautiful song, he ordered the sailors to untie him but they bound him tighter.

When ownership of a digital signature secret key is bound to a specific user, a valid signature shows that the message was sent by that user.

De amore lists such rules as " Marriage is no real excuse for not loving ", " He who is not jealous cannot love ", " No one can be bound by a double love ", and " When made public love rarely endures ".

When the river Amasenus blocked his path, he bound her to a spear and promised Diana that Camilla would be her servant if she would safely transported to the opposite bank.

When meat is in its raw state, the iron atom is in the + 2 oxidation state, and is bound to a dioxygen molecule ( O < sub > 2 </ sub >).

When nucleons bind together to form a nucleus, they must lose a small amount of mass, i. e., there is mass change, in order to stay bound.

When Jacob confronted the redcoats, they bound him to a tree with a bridle bit in his mouth.