When a ligand activates the G protein-coupled receptor, it induces a conformational change in the receptor that allows the receptor to function as a guanine nucleotide exchange factor ( GEF ) that exchanges GDP for GTP on the G < sub > α </ sub > subunit.

When blood flow is suppressed, glutamate is released from presynaptic neurons causing NMDA and AMPA receptor activation moreso than would normally be the case outside of stress conditions, leading to elevated Ca < sup > 2 +</ sup > and Na < sup >+</ sup > entering the post synaptic neuron and cell damage.

When a signal comes down an axon, the synaptic vesicles fuse with the cell membrane releasing the neurotransmitter so that it can be detected by receptor molecules on the next nerve cell.

When light falls on a receptor it sends a proportional response synaptically to bipolar cells which in turn signal the retinal ganglion cells.

When a ligand binds to a G protein-coupled receptor ( GPCR ) that is coupled to a Gq heterotrimeric G protein, the α-subunit of Gq can bind to and induce activity in the PLC isozyme PLC-β, which results in the cleavage of PIP < sub > 2 </ sub > into IP < sub > 3 </ sub > and DAG.

When the vrll membrane receptor and insulin bind, the cell takes up glucose ( sugar ) from the blood and can use it for energy.

When accelerated growth is present, it is thought to result from the duplication of the IGF1 receptor gene.

When the synapse releases glutamate onto the postsynaptic cell, it opens ionotropic glutamate receptor channels.

When the inducer binds the receptor, it activates transcription of certain genes, including those for inducer synthesis.

When acetylcholine binds to an already depolarized receptor, it cannot cause further depolarization.

When GPIIb / IIIa receptor is dysfunctional, fibrinogen cannot cross-link platelets, which inhibits primary hemostasis.

When prolactin binds to the receptor, it causes it to dimerize with another prolactin receptor.

When transmural pressure increases, sphingosine kinase 1 phosphorylates sphingosine to S1P, which binds to the S1P2 receptor in plasma membrane of cells.

When THG reaches the nucleus of a cell, it binds to the androgen receptor at the ligand-binding pocket.

When an ionotropic receptor is activated, it opens a channel that allows ions such as Na < sup >+</ sup >, K < sup >+</ sup >, or Cl < sup >-</ sup > to flow.

When a ligand ( the neurotransmitter ) binds to the receptor ( the transducer ) the latter activates a primary effector via the G-protein, which can go on to activate secondary messengers or have other effects.

When NMDA receptor antagonists are given to rodents in large doses, they can cause a form of brain damage called Olney's Lesions.

When there is high-frequency NMDA receptor activation, there is an increase in the expression of a protein PSD-95 that increases synaptic capacity for AMPA receptors.

When the virus comes in contact with the membrane of a host cell, it binds to a receptor site and triggers a folding-in of the membrane.

When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell ( e. g., to erythroid precursors in the bone marrow ), it binds to it and, as a consequence, is transported into the cell in a vesicle by receptor-mediated endocytosis.

When glutamate binds to the AMPA receptor, the membrane depolarizes.

When he comes to his senses, covered in blood, and realizes what he has done, with diminished honor he decides that he prefers to kill himself rather than to live in shame.

When the throat chakra settles and energy is distributed evenly between the head and the heart chakras, one is able to truly contact one's senses and touch real feelings.

When O ' Shaughnessy contacts Spade, he senses a connection between her and Cairo, and casually mentions that he has spoken to Cairo.

When the boy flees the scene and Valjean comes to his senses, remembering what the bishop had done for him, he is horribly ashamed of what he has done and searches for the boy in vain.

When feeling motion but not seeing it ( for example, in a ship with no windows ), the inner ear transmits to the brain that it senses motion, but the eyes tell the brain that everything is still.

* pun: When a word or phrase is used in two ( or more ) different senses

When worship involves the use of the entire body, and all the senses, the Orthodox believe this becomes very helpful in learning to actively love God with all their " mind, soul, heart and strength " as God commands.

* When confronted with objects of the six senses, he or she has equanimity and is not confused, seeing only what is seen, and hearing only what is heard, not mental projections and elaborations such as attachment, desire, and aversion ;

When there is an excess of hormone Y, gland X " senses " this and inhibits its release of hormone X.

When Lily Kimble, who used to be in Halliday's employ, reads an advertisement, placed by Gwenda, seeking information about Helen, she senses there could be money in it ; and after a second advertisement appears looking for her personally, she writes to Dr Kennedy asking for his advice.

When big-game hunter Sergei Kravinoff is attacked and nearly killed by Hyenas, he is saved by the administration of a miracle drug which, in addition to curing his wounds, grants him heightened senses and physical abilities.

When he reaches the point of envying the pigs he is looking after, he finally comes to his senses:

When they fall deeply in love, Robert senses the doomed nature of such a relationship, flees to Mexico under the guise of pursuing a nameless business venture.

When His own people heard of this, they went out to take custody of Him ; for they were saying, " He has lost His senses.

When there is a demand for hot water ( e. g. a hot water tap is opened for a sink, shower, tub, or washing machine ) the tankless water heater's water flow turbine senses the flow and starts the heating process.

When the Control Trac 4x4 system senses rear wheels slipping, it transfers power to the front wheels.

“ People are more likely to believe that the first things they learn are the truth .” When the other person or group is absorbing the message they are focused on the entire environment around them, meaning, the other person uses all five senses in the interaction.

When our bodily senses shut down temporarily, and we descend into dream or somnambulic trance, our soul " wakes up " to the larger world whence it has come and where it really belongs.

" When ," declared Sunderland, " a ” magnetic “ relation is once established between an operator and his patient ..., corresponding changes may be induced in the nervous system of the latter ( awake or entranced ) by mere volition, and by suggestions addressed to either of the external senses .” Sunderland published the revue “ The Magnet ”.

" When asked about her experiences working with different nationalities and cultures on set, Lusha was quoted as saying: " As actors, we dug so deep into our senses, our country's borders and cultures blurred into one pot of emotion, and we performed above the complexities of language and formality.

When an investor asks a broker to purchase securities on margin, hypothecation can occur in two senses.

When she comes to her senses and releases him, his suit is destroyed and he is clearly traumatized almost close to death.

When a runner senses a car coming towards them, they must look for cover and hide themselves in a nearby yard in order to avoid being caught.

When he regains his senses, he says that he is saved and that he has accepted Jesus as his savior.