They are often portrayed as children with Williams syndrome ( which was not recognised as a medical condition but some specialist believe that people were enchanted with their character and appearance that they believed to be magical ), usually with fair hair.

In 2011, Williams was forced to withdraw from the US Open before her second-round match, following a Sjögren's syndrome diagnosis.

* Williams syndrome, a rare neurodevelopmental disorder

Williams syndrome ( WS or WMS ; also Williams – Beuren syndrome or WBS ) is a rare neurodevelopmental disorder characterized by a distinctive, " elfin " facial appearance, along with a low nasal bridge, an unusually cheerful demeanor and ease with strangers ; developmental delay coupled with strong language skills ; and cardiovascular problems, such as supravalvular aortic stenosis and transient hypercalcaemia.

The syndrome was first identified in 1961 by Dr. J. C. P. Williams of New Zealand and has an estimated prevalence of 1 in 7, 500 to 1 in 20, 000 births.

Williams syndrome was first described by Dr. J. C. P.

K. Jones and D. Smith conducted a large-scale report on numerous patients with Williams syndrome, ranging in age from infancy to adulthood, and described the behavioral and observable physical symptoms in greater detail than previously recorded.

Williams syndrome is caused by the deletion of genetic material from the region q11. 23 of chromosome 7.

, ELN,,, and are among the genes that are typically deleted in people with Williams syndrome.

Additionally, there is evidence that the loss of several of these genes, including CLIP2, may contribute to the unique behavioral characteristics, learning disabilities, and other cognitive difficulties seen in Williams syndrome.

Williams syndrome has historically been estimated to occur in roughly 1 in every 20, 000 live births.

As an increasing body of evidence suggests that Williams syndrome is more common than originally noted ( approximately 6 % of all genetic cases of developmental disability ), researchers have begun to theorize past under-diagnosis of the disorder.

One theorized reason for the increase in epidemiological estimates is that there exists a substantial minority of individuals with the genetic markers of Williams syndrome who lack the characteristic facial features or the diminished IQ considered to be diagnostic of the disorder, who often are not immediately recognized as people with the syndrome.

According to the Williams Syndrome Association, diagnosis of Williams syndrome begins with recognition of physical symptoms and markers, which is followed by a confirmatory genetic test.

The physical signs that often indicate a suspected case of Williams syndrome include puffiness around the eyes, a long philtrum, and a stellate pattern in the iris.

Physiological symptoms that often contribute to a Williams syndrome diagnosis are cardiovascular problems, particularly aortic or pulmonary stenosis, as well as feeding disturbance in infants.

If a physician suspects a case of Williams syndrome, the diagnosis is confirmed using one of two possible genetic tests: micro-array analysis or the fluorescent in situ hybridization ( FISH ) test.

Since 98-99 % of individuals with Williams syndrome lack half of the 7q11. 23 region of chromosome # 7, where the elastin gene is located, the presence of only one copy of the gene is a strong sign of the disorder.

This confirmatory genetic test has been validated in epidemiological studies of the disorder, and has been demonstrated to be a more effective method of identifying Williams syndrome than previous methods, which often relied on the presence of cardiovascular problems and facial features ( which, while common, are not always present ).

Some diagnostic studies suggest that reliance on facial features to identify Williams syndrome may cause a misdiagnosis of the condition.

G. Mennen Williams is learning the difficulties of diplomacy rapidly.

`` Last year your Tennessee Williams told our Dilys Powell, in a television program, that it is the task of the playwright to throw light into the dark corners of the human heart.

You know where Tim is, don't you, Mrs. Williams ''??

Williams is a defensive coach.

A teenage girl, Abigail Williams, is being sharply questioned by her minister uncle, the Reverend Samuel Parris, about a wild night affair in the woods in which she and some other girls had seemed to have had contact with these evil beings.

The present incumbent is Rowan Williams.

Several biographical programs have been made, such as the 2004 BBC television programme entitled Agatha Christie: A Life in Pictures, in which she is portrayed by Olivia Williams, Anna Massey, and Bonnie Wright.

Raymond Williams argues that there is no unique and or individual aesthetic object which can be extrapolated from the art world, but that there is a continuum of cultural forms and experience of which ordinary speech and experiences may signal as art.

The current archbishop is the Most Reverend Rowan Williams.

The current archbishop, the Most Reverend and Right Honourable Rowan Douglas Williams, is the 104th Archbishop of Canterbury.

Examples include Edward Elgar's Great is the Lord ( 1912 ) and Give unto the Lord ( 1914 ) ( both with orchestral accompaniment ), Benjamin Britten's Rejoice in the Lamb ( 1943 ) ( a modern example of a multi-movement anthem and today heard mainly as a concert piece ), and, on a much smaller scale, Ralph Vaughan Williams ' O taste and see ( 1952 ) ( written for the coronation of Queen Elizabeth II ).

Continuing from Evil Dead II, Ash Williams is trapped in the Middle Ages and battles the undead in his quest to return to the present.

After being pulled through a time portal, Ash Williams lands in 1300 AD, where he is almost immediately captured by Lord Arthur's men, who suspect him to be an agent for Duke Henry, with whom Arthur is at war.

This is a tour of American music — jump blues, slow blues, rockabilly, Tin Pan Alley ballads, Country Swing — that evokes the sprawl, fatalism and subversive humor of Dylan's sacred text, Harry Smith's Anthology of American Folk Music, the pre-rock voicings of Hank Williams, Charley Patton and Johnnie Ray, among others, and the ultradry humor of Groucho Marx.

The record for the highest career OBP by a hitter, based on over 3000 plate appearances, is. 482 by Ted Williams.

Jefferson's earnings reputedly enabled him to buy a car and employ chauffeurs ( although there is debate over the reliability of this as well ); he was given a Ford car " worth over $ 700 " by Mayo Williams, Paramount's connection with the black community.

Guitarist Christopher Parkening is quoted in the book Classical Gas: The Music of Mason Williams as saying that it is the most requested guitar piece besides Malagueña and perhaps the best known instrumental guitar piece today.

Public discourse ranged in tone from organized arguments by tobacconist and medical practitioner John Williams, who posited that " several arguments proving that inoculating the smallpox is not contained in the law of Physick, either natural or divine, and therefore unlawful ," to more slanderous attacks, such as those put forth in a pamphlet by Dr. William Douglass of Boston entitled The Abuses and Scandals of Some Late Pamphlets in Favour of Inoculation of the Small Pox ( 1721 ), on the qualifications of inoculation's proponents.

" However, and Williams questioned whether the smallpox " is not one of the strange works of God ; and whether inoculation of it be not a fighting with the most High.

The game cover itself is a parody of Army of Darkness, while Duke poses as Ash Williams.

* Bruce Campbell as Ashley " Ash " Williams: Ash is the last survivor of the group and the main protagonist of the film.

Vermont historian Samuel Williams called it " an act which for its savage barbarity is probably without parallel in the legislation of any civilized country ".