Without kinase activity, EGFR is unable to activate itself, which is a prerequisite for binding of downstream adaptor proteins.

Without balanced job complexes, most workers would most likely end up merely ratifying the proposals of empowered workers, and would have little reason to attend meetings.

Without this power we lay open any American industry which the Europeans may find it economically profitable to destroy to the will of others.

Without comment he opened the closet and from its shelves constructed a highboard around the egg case which he had placed on the floor inside.

A true university, like most successful marriages, is a unity of diversities Without forcing all components into a single pattern, the preparation of a master plan is an opportunity to consider interrelation of knowledge at its highest level, which a university -- in contrast to a multiversity -- should stand for.

Without further discussion he appeared the next morning with a pile of boards sticking over the end of his light truck and proceeded with the paneling, which he then stained and waxed according to his taste.

Without taking off his coat, he sat in the blue chair which still faced the closed bedroom door.

`` Without any officious and improper interference on the subject, the price of labor or the wages of mechanics will be regulated by the demand for the manufactured article and the value of that which is paid for it ; ;

" Without a clear Sinhala connection, they suggest one from the Tamil language instead: anai-kondra ( anaik-konda ), meaning " which killed an elephant .” Per National Geographic, the word anaconda comes from the Tamil word anaikolra, which means elephant killer.

Chapter 17 of William Bates ' 1920 book Perfect Sight Without Glasses, in which the author argues that observation of the sun is beneficial to those with poor vision, includes a figure of somebody " Focussing the Rays of the Sun Upon the Eye of a Patient by Means of a Burning Glass.

Without a television station to subsidize the newspaper, the Herald Traveler was no longer able to remain in business, and the newspaper was sold to Hearst Corporation, which published the rival all-day newspaper, the Record American.

Without firing a shot, by the mere display of military force, he has achieved a dominating position in Europe which Germany failed to win after four years of war.

Without nurturing feelings of the heart a subtle form of anxiety arises which results in the self reaching out for experience.

According to Tibor R. Machan, " Without a market in which allocations can be made in obedience to the law of supply and demand, it is difficult or impossible to funnel resources with respect to actual human preferences and goals.

* Discordian texts and scriptures include Principia Discordia, Black Iron Prison, Zen Without Zen Masters, Liber Malorum, Book 5 ( The Zenarchist's Cookbook ), Zenarchy Unapologia, The Book of the Apocalypso, The Book of Eris, The Book of Inconveniences, The Honest Book of Truth ( portions of which are used in Principia Discordia ), Jonesboria Discordia, Metaclysmia Discordia, Novus Ordo Discordia, Principia Harmonia, Aeturnus Ille Discordia, The Wise Book of Baloney, The Book of Life, The Book of Chaos and Its Virtue, Chao Te Ching, Summa Discordia, Voices of Chaos, The Book of Chaos, Apocrypha Discordia, Principia Entropius, etc.

" Without these questions there is no clear fulcrum on which to balance law, politics, and the practice of arbitration — in fact, no common assumptions of all participants — so the ability to formulate the questions are prior to rights balancing.

The scene in which Lee states that his style was the style of " Fighting Without Fighting " and then lures Parsons into boarding a dinghy is based upon a famous anecdote involving the 16th century samurai Tsukahara Bokuden.

* 1808 – Without a previous declaration of war, Russian troops cross the border to Sweden at Abborfors in eastern Finland, thus beginning the Finnish war, in which Sweden will lose the eastern half of the country ( i. e. Finland ) to Russia.

Lord Goldsmith, the then Attorney General, then pressed forward with the Fraud ( Trials Without a Jury ) Bill in Parliament, which sought to abolish jury trials in major criminal fraud trials.

The band's American breakthrough came with the third album, Travelling Without Moving in 1996, which yielded two big hits, " Virtual Insanity " and " Cosmic Girl ".

In November, Kid Rock released Cocky, which was marketed as the official follow up to Devil Without a Cause.

Without this capacity, which is often the case in practice, to produce a representation with lower resolution or lower fidelity than a given one, one needs to start with the original source signal and encode, or start with a compressed representation and then decompress and re-encode it ( transcoding ), though the latter tends to cause digital generation loss.

Without the 24 hour dredging, the Mouth would silt up and close, cutting the supply of fresh sea-water into the Coorong, which would then warm up, stagnate and die.

Without the commissions, the appointees were unable to assume the offices and duties to which they had been appointed.

Without breaking entirely from the past, Marx established the principles which would be used by the future revolutionaries of the 20th century namely Vladimir Lenin, Mao Zedong, Ho Chi Minh and Fidel Castro.

The first single from Spellbound was the ballad, " Rush, Rush ," which topped the Billboard Hot 100 chart for five consecutive weeks, and was noted for its music video and Rebel Without a Cause motif featuring Keanu Reeves in the James Dean role.

Without saying or seeming to say that in portraying the Sartoris and the Compson families Faulkner's chief concern is social criticism, we can say nevertheless that through those families he dramatizes his comment on the planter dynasties as they have existed since the decades before the Civil War.

Without a precise knowledge of Germanic philology, however, it is debatable whether their use was not more often a source of confusion and error than anything else.

Without such forward planning, investment funds are wasted because manufacturing facilities are completed before there is power to operate them or before there is transport to service them ; ;

Without losing the distinctive undertow of Brahmsian rhythm, the pacing is firm and the over-all performance has a tightly knit quality that makes for maximum cumulative effect.

Without such a declaration, Paine concluded, “ he custom of all courts is against us, and will be so, until, by an independence, we take rank with other nations .”

Without this money creation benefit, it is actually more expensive to outsource the IT operations as the outsourcing adds a layer of management and increases overhead.

Without a freewheel, coasting is impossible, so when the rear wheel is moving, the cranks are moving.

Without diagnosis and treatment, the infection can be fatal in one to six days ; mortality in untreated cases is approximately 100 %.

Without clear documentation, software can be hard to use — especially if it is very specialized and relatively complex like Photoshop or AutoCAD.

Without protected memory, it is possible that a bug in one program will alter the memory used by another program.

Without salvation from sin ( see below ), a person's separation from God is permanent, causing such a person to enter Hell in the afterlife.

Guided by Arkyn, Corum, Rhalina and companion Jhary-a-Conel cross the planes and encounter the King Without A Country, the last of his people who in turn is seeking the City in the Pyramid.

: Without doubt this is the most important work on general algebra that the Annalen has ever published.

Without experience of meditation, one's knowledge of the world is too limited to fully understand dukkha, as required by the first noble truth, and proceed to enlightenment.

Without a price mechanism, socialism lacks the means to relate consumer satisfaction to economic activity, it is argued.

Without this suffix, a countable noun is understood to be singular.