In 1859, Nobel's father left his factory in the care of the second son, Ludvig Nobel ( 1831 – 1888 ), who greatly improved the business.

* 1888 – Herbert Spencer Gasser, American physiologist, Nobel Prize laureate ( d. 1963 )

* 1888 – Frits Zernike, Dutch physicist, Nobel Prize laureate ( d. 1966 )

* 1888 – Selman Waksman, Ukrainian-born American biochemist, Nobel Prize laureate ( d. 1973 )

* 1888 – Sir C. V. Raman, Indian physicist, Nobel Prize laureate ( d. 1970 )

* 1888 – Eugene O ' Neill, American writer, Nobel Prize laureate ( d. 1953 )

* 1888 – Frans Eemil Sillanpää, Finnish author, Nobel Prize laureate ( d. 1964 )

* June 3 – Frans Eemil Sillanpää, Finnish writer, Nobel Prize laureate ( b. 1888 )

** Otto Stern, German physicist, Nobel Prize laureate ( b. 1888 )

* May 11 – Herbert Spencer Gasser, American physiologist, Nobel Prize laureate ( b. 1888 )

** Frits Zernike, Dutch physicist, Nobel Prize laureate ( b. 1888 )

** Selman Waksman, Ukrainian-born biochemist, recipient of the Nobel Prize in Physiology or Medicine ( b. 1888 )

Eugene Gladstone O ' Neill ( October 16, 1888 – November 27, 1953 ) was an American playwright and Nobel laureate in Literature.

Frits Zernike (; July 16, 1888 – March 10, 1966 ) was a Dutch physicist and winner of the Nobel prize for physics in 1953 for his invention of the phase contrast microscope, an instrument that permits the study of internal cell structure without the need to stain and thus kill the cells.

* Chandrasekhara Venkata Raman ( 1888 – 1970 ), was an Indian physicist and Nobel laureate in physics.

* Otto Stern ( 1888 – 1969 ), physicist and Nobel laureate

* August 17-Otto Stern ( born 1888 ), German physicist, Nobel laureate in Physics in 1943.

* 21 November-C. V. Raman, physicist, awarded the 1930 Nobel Prize in Physics ( b. 1888 ).

* Shmuel Yosef Agnon ( 1888 – 1970 ), Nobel Prize-winning author

Herbert Spencer Gasser ( July 5, 1888 – May 11, 1963 ) was an American physiologist, and recipient of the Nobel Prize for Physiology or Medicine in 1944 for his work with action potentials in nerve fibers while on the faculty of Washington University in St. Louis, awarded jointly with Joseph Erlanger.

A few months later he joined the Nobel's mechanical factory owned by a Swede named Ludvig Nobel ( 1831 – 1888 ), brother of Alfred Nobel of Nobel Prize fame, where he worked until 1877.

Ludvig Immanuel Nobel ( phonetic: ) ( Stockholm, 27 July 1831 – Cannes, March 1888 ( or 12 April 1888: sv: Ludvig Nobel )) was an engineer, a noted businessman and a humanitarian.

The first result of Heidenstam's long sojourn abroad was a volume of poems, Pilgrimage And Wander-Years ( Vallfart och Vandringsar ), published in 1888.

After correspondence with Miss Packard and to the joy of Miss Packard and Miss Giles, she came to Atlanta, in the fall of 1888, to help wherever needed, although there was then no money available to pay her a salary.

One of the enduringly influential early resolutions of the conference was the so-called Chicago-Lambeth Quadrilateral of 1888.

Amos Bronson Alcott ( November 29, 1799 – March 4, 1888 ) was an American teacher, writer, philosopher, and reformer.

As he was bedridden at the end of his life, Alcott's daughter Louisa May came to visit him at Louisburg on March 1, 1888.

The Concord School of Philosophy, which closed following Alcott's death in 1888, was reopened almost 90 years later in the 1970s.

He was the third of the four children of farmer Hugh Fleming ( 1816 – 1888 ) from his second marriage to Grace Stirling Morton ( 1848 – 1928 ), the daughter of a neighbouring farmer.

From the end of 1888, the Amir spent eighteen months in his northern provinces bordering upon the Oxus, where he was engaged in pacifying the country that had been disturbed by revolts, and in punishing with a heavy hand all who were known or suspected to have taken any part in rebellion.

An école normale ( an institute for training primary school teachers ) was founded in Barcelonnette in 1833, and remained there until 1888 when it was transferred to Digne.

An identical expression to Einstein's formula for the diffusion coefficient was also found by Walther Nernst in 1888 in which he expressed the diffusion coefficient as the ratio of the osmotic pressure to the ratio of the frictional force and the velocity to which it gives rise.

The first patent on a ballpoint pen was issued on 30 October 1888, to John Loud, a leather tanner, who was attempting to make a writing instrument that would be able to write on his leather products, which then-common fountain pens could not do.

In 1888, when he was seven, his father ( the director of an agricultural school ) died suddenly.

Bundaberg rum was first produced in 1888, production ceased from 1907 to 1914 and from 1936 to 1939 after fires, the second of which caused rum from the factory to spill into the nearby Burnett River.

In 1888, all production was moved, by Edward Drummond Libbey, to Toledo, Ohio, where it continues today under the name Owens Illinois.

First published in The San Francisco Examiner on June 3, 1888, it was later popularized by DeWolf Hopper in many vaudeville performances.

The text is filled with references to baseball as it was in 1888, which in many ways is not far removed from today's version.

The Cottage was lived in by Edward Bulwer-Lytton ( who wrote The Last Days of Pompeii ) and other somewhat notable ( and moneyed ) persons until it was destroyed by fire in May 1888.

Of particular note, was Ranelagh House, Fulham's palatial home from 1886 – 1888.

The Kingdom of Rarotonga was established in 1858 and in 1888 it became a British protectorate by the request of Queen Makea Takau, mainly to thwart French expansionism.

In the United Kingdom the original Board of Trade carat was exactly (≈ 3. 170 ) grains ; in 1888, the Board of Trade carat was changed to exactly (≈ 3. 168 ) grains.

From 1888, block printing was limited to short run specialist jobs.