However, after enough carbamazepine has been presented to the liver tissue, the CYP3A4 activity increases, speeding up drug clearance and shortening the half-life.

( However, the colloquial form written as em ", as in " up and at ' em ", may well represent a spoken survival of " hem " rather than a shortening of the Norse-derived " them ".

However, because of DNA replication mechanisms, oxidative stress, and, because TERT expression is very low in many types of human cells, the telomeres of these cells shrink a little bit every time a cell divides, although, in other cellular compartments that require extensive cell division, such as stem cells and certain white blood cells, TERT is expressed at higher levels and telomere shortening is partially or fully prevented.

However, the practicality of this solution is limited by the resulting high recharge current through the equivalent series resistance ( ESR ) of the capacitors ; the ESR will dissipate some of the recharge current, generating heat within the capacitors and potentially shortening their lifetime.

However, shortening the CCC creates its own risks: while a firm could even achieve a negative CCC by collecting from customers before paying suppliers, a policy of strict collections and lax payments is not always sustainable.

However, this shortening of / o :/ / ø :/ / a :/ / æ :/ is not general.

However in unilateral cases ( e. g. post traumatic ), there may be shortening, leading to a short limb gait characterised by limp which is seen as a vertical dip on the affected side during the stance phase ( as opposed to a lurch characterised in a Trendelenburg gait ).

However, the novel depicted the process as shortening the star's lifespan precipitously rather than extending it.

However, the propeller required shortening before trials commenced because of its " greatly excessive vibration.

However, on a rotating planet, it must also be taken into account that the receiver moves during the transit time of the signal, shortening or lengthening the transit time compared to what it would be in the situation of a non-rotating planet.

However, the interconnects ( metal and poly pitch ) continue to shrink, thus reducing chip area and chip cost, as well as shortening the distance between transistors, leading to higher performance devices of greater complexity when compared with earlier nodes.

However, after long discussion among students and staff, the school decided not to adopt the schedule proposed by the current principal, due to other problems in the proposed schedule, such as shortening of Family Group and Committee meetings and difficulty in scheduling some classes.

However, the stirrup, which made the ' shock cavalry ' lance charge possible, was not introduced to the Frankish kingdom until the late eighth century.

However, this placement actually puts the stirrup on the arch of the foot, in a weaker position that leads to tension in the leg, stiffness in the knee and decreases the flexibility of the ankle, and therefore the shock-absorbing ability of the rider ; paradoxically increasing the risk of a fall.

However much football has been over-emphasized, the public likes to measure its collegiate favorites by the scoreboard, so, while Yale need never give its record a thought again since outscoring its opponents 694 to 0 in the season of 1888, Dartmouth had to wait until its championship team of 1925 for national recognition.

However, it did not come into general use until Joseph Greenberg ( 1963 ) formally proposed its adoption.

However, these scripts either count di-and tri-graphs as separate letters, as Spanish did with ch and ll until recently, or uses diacritics like Slovak č.

However, they will often use the same den as their mother until the next breeding season.

However, this was not successful, for according to Gregory of Tours, Amalaric pressured her to forsake her Roman Catholic faith and convert to Arian Christianity, at one point beating her until she bled ; she sent to her brother Childebert I, king of Paris a towel stained with her own blood.

However, he continued his slave trading career until 1754 or 1755, when he ended his seafaring altogether and began studying Christian theology.

" However, he did not begin his philanthropic work in all earnest until 1881, with the gift of a library to his hometown of Dunfermline, Scotland.

However, until the Revolution, many considered whiskey to be a coarse alcohol unfit for human consumption, as many believed that it caused the poor to become raucous and unkempt drunkards.

However, other scholars have argued that though 80 % of al-Andalus converted to Islam, it did not truly occur until near the 10th century.

However, Beethoven did not retain this version, and kept rewriting until he had found its final form, with the words < em lang =" de ">" O Freunde, nicht diese Töne "</ em > (" O friends, not these tones ").

However infection at an intermediate stage, before the fetal immune system is fully developed, may result in a chronic infection that lingers until the first months after birth of the lamb.

However, the parting was amicable as Kahn remained on the Borland board until November 7, 1996, when he resigned from that position.

However, with the Franco-Bavarian commanders reluctant to fight until their numbers were deemed sufficient, the Duke enacted a policy of plundering in Bavaria designed to force the issue.

However, Marlborough would have to wait until Eugene was in position before the general engagement could begin.

However, it was not until 21: 00 that the Marquis de Blanzac, who had taken charge in Clérambault's absence, reluctantly accepted the inevitability of defeat, and some 10, 000 of France's best infantry had laid down their arms.

However, no borough was actually created under law until 2005 – 2006, when Neve Monosson and Maccabim-Re ' ut, both communal settlements ( Heb: yishuv kehilati ) founded in 1953 and 1984, respectively, were declared to be autonomous municipal boroughs ( Heb: vaad rova ironi ), within their mergers with the towns of Yehud and Modi ' in.

However, the French did not consolidate their control over the area until 1903, after having defeated the forces of Rabih in the battle of Kousséri, and established colonial administration throughout the territory.

" However, the first operational British A Bomb was not detonated until October 1952, about one year after Attlee had left office.

However, another observer cannot benefit until the results of that measurement have been relayed to him, at less than or equal to the speed of light.

However, the holiday was not established statutorily until 1879, when it was designated as Dominion Day, in reference to the designation of the country as a Dominion in the British North America Act.

However, such factories are unlikely to achieve " full closure " until the cost and flexibility of automated machinery comes close to that of human labour and the manufacture of spare parts and other components locally becomes more economical than transporting them from elsewhere.

However, since primogeniture and the Salic Law provided for the succession of the French throne for most of French history, here is a list of all the predecessors of the French monarchy, all the French kings from Hugh until Charles, and all the Legitimist pretenders thereafter.

However, the council was delayed until 1545 and, as it happened, convened right before Luther's death.

However, an Assyrian king Ashur-uballit II held out at the Assyrian city of Harran, resisting until 605 BC, when the remnants of the Assyrian Army and an Egyptian force were defeated at Karchemish.

However, this rivalry did not begin to grow until, when the Brewers moved from the American League Central Division to the NL Central.

However, in the sprint event the rider's position is more extreme compared with a road rider.

However, if the rider mistimes his cue to the horse and the horse breaks the barrier before it releases, a 10-second penalty will be added to his time.

However, this depends on water conditions, the weight of the rider, their proficiency in the sport as well as a preference matter of the rider.

However, the rider also has the challenge of staying on over the fence and controlling the horse through rapid changes of pace and direction, so still needs some length of leg for stability.

However, the evolution of very low rider torso positions to reduce aerodynamic drag for time trial racing and triathlon cycling can also affect crank selection for such events.

However, a rider will almost always feel some degree of gentle side-to-side motion in the horse's hips as each hind leg reaches forward.

However, a camel is much taller than a horse and so even at relatively fast speeds, a rider can follow the rocking motion of a camel.

However, the option does exist to add a " Return of Premium " rider which pays back to the insured all premiums less claims paid out if the plan is never actually used.

However, the program suffered from perennially low membership and rider usage rates, as well as a limited number of bike rental stations.

However, during the withdrawal two Australians were left behind and were subsequently captured by the Chinese: Private Robert Parker, the battalion despatch rider, and Private Horace Madden, one of the signallers.

However, crash bracelets can also potentially harm the rider ; if the rider falls from a great height, the sudden stop can cause arm and shoulder injuries.

However, single-track and streams ( like in mountain biking ) are also sometimes part of the course, depending on the location, both of which require rider experience and technique.

However, this may be misleading ; the horn is not meant to be a handle for the rider to hang onto, and the high cantle and heavy stirrups are not for forcing the rider into a rigid position.

However, the practice is highly dangerous to both dragon and rider and is severely restricted.

However, the horse also has a bit of a spring in its motion as it switches diagonal pairs of legs with each beat, and thus can be rough for a rider, and jostles about packs or weaponry to a considerable degree.

However, her rider, Baron Sanci, arrives late.

However, by watching a variety of riders test out the new product, there emerged a rider who took to the sport more like a surfboard than a skateboard.

However, instead of sitting above the wheel, the rider sits either within it or next to it.

However, ridership had " increased 30 percent since it began, and every new V rider, as lonely as he or she might be, relieves crowding on the.

However, Lane's father, Clyde Frost, was on the rodeo circuit as a saddle bronc and bareback rider, and Lane's mother, Elsie, went to stay with her parents in Kim, Colorado, while she waited for Lane to arrive.