* Pope Adrian VI ( 1459 – 1523 ), Dutch pope

* 1421 – 1459: Stephan Bodecker

* 1459 – Adolf VIII, Duke of Southern Jutland ( b. 1401 )

* 1525 – Jakob Fugger, German banker ( b. 1459 )

* 1380 – Gian Francesco Poggio Bracciolini, Italian humanist ( d. 1459 )

* 1508 – Conrad Celtes, German humanist scholar ( b. 1459 )

* Maximilian ( 1459 – 1519 ), Holy Roman Emperor, married

Maximilian I, Holy Roman Emperor ( 1459 – 1519 ) is often referred to as the last true knight.

* Pienza, possibly as consultant ( 1459 – 62 )

* 1389 – Saint Antoninus of Florence, Archbishop of Florence ( d. 1459 )

* 1459 – Pope Adrian VI ( d. 1523 )

* 1459 – Jakob Fugger, German banker ( d. 1525 )

* 1459 – Maximilian I, Holy Roman Emperor ( d. 1519 )

* 1459 – Martin Behaim, German navigator and geographer ( d. 1507 )

Pope Adrian VI (, ), born Adriaan Florenszoon Boeyens ( 2 March 1459 – 14 September 1523 ), served as the 218th Pope of the Catholic Church from 9 January 1522 until his death on 14 September 1523, 1 year and 248 days later.

* 1459 – Battle of Blore Heath, the first major battle of the English Wars of the Roses, is fought at Blore Heath in Staffordshire.

* February 11 – Gian Francesco Poggio Bracciolini, Italian humanist ( d. 1459 )

** February 11 – Gian Francesco Poggio Bracciolini, Italian humanist ( d. 1459 )

* October – Edward Poyning, Lord Deputy to King Henry VII of England ( b. 1459 )

* January 12 – Lorenzo di Credi, Florentine painter and sculptor ( b. 1459 )

* January 12 – Maximilian I, Holy Roman Emperor ( b. 1459 )

* February 6 – Lorenz von Bibra, Prince-Bishop of the Bishopric of Würzburg ( b. 1459 )

* February 25 – Cem Sultan, pretender to the Ottoman throne ( b. 1459 )

* September 14 – Pope Adrian VI ( b. 1459 )

His father had been carver and sword-bearer to Jack Cade, and was killed at the Second Battle of St Albans on 17 February 1461 ; his mother, who was born on 1 July 1429, and married Poynings in December 1459, inherited her husband's property in Kent, in spite of opposition from her brother-in-law, Edward Poynings, master of Arundel College ; before 1472 she married a second husband, Sir George Browne of Betchworth, Surrey, by whom she had a son Matthew and a daughter.

* 1472: Abu Abdallah sheikh Muhammad ibn Yahya, one of the two Wattasid vizirs surviving the 1459 massacre, installs himself in Fes, where he founds the Wattasid dynasty.

The Lancastrian forces captured Ludlow in 1459, but at the end of the conflict in 1461 the castle became property of the Crown and passed to Richard's son, Edward IV.

Afterwards, in 1458, he helped to reconcile the contending parties, but when the war was renewed in 1459 he appears as a decided Yorkist ; he crowned King Edward IV in June 1461, and four years later he crowned the queen, Elizabeth Woodville.

Holstein on the other hand, after the death of Adolphus IV in 1261, was split up into several countships by his sons and again by his grandsons ( 1290 ): the lines of Holstein-Kiel ( 1261 – 1390 ), Holstein-Pinneberg and Schaumburg ( 1290 – 1640 ) south of the Elbe, Holstein-Plön ( 1290 – 1350 ), Holstein-Rendsburg ( 1290 – 1459 ), and at times also Holstein-Itzehoe ( 1261 – 1290 ) and Holstein-Segeberg ( 1273 – 1315 ), and again 1397 – 1403 ), all named after the comital residential cities.

* John IV of Trebizond ( c. 1403 – 1459 )

John IV ( 1429 – 1459 ) could not help but see his Empire would soon share the same fate as Constantinople had suffered in 1453.

" ( IV, CLXIII, 161-163 ; 1459 – 67 ).

Oaths of allegiance were exacted from Lords, by Henry IV and Henry VI in 1455 and 1459, and oath of supremacy was introduced under Henry VIII in 1534.

* 1454 – 1459: Johannes von Baysen ( Jan Bażyński ), war-time governor

* 1459 – 1480: Stibor ( Tiburcius ) von Baysen / Ścibor Bażyński

Martin ( von ) Behaim ( 6 October 6, 1459 – 29 July 1507 ), ( also known as Martinho da Boémia, Martin Bohemus, Martin Behaim von Schwarzbach, or ) was a German mariner, artist, cosmographer, astronomer, philosopher, geographer and explorer in service to the King of Portugal.

* Helmich von Mallinkrodt 1459 – 68

In May of 1459, a controversy arose when Diether von Isenburg was elected as Archbishop of Mainz, yet failed to pay the required annates, and so, Adolph von Nassau was given the position.

* Eskender, Emperor of Ethiopia ( 1472 – 1494 )

* 1434 – Janus Pannonius, Hungarian bishop, poet, and diplomat ( d. 1472 )

* 1472 – 1485: Arnold von Burgsdorff

* House of Artois ( 1237 – 1472 )

* 1472 – Orkney and Shetland are pawned by Norway to Scotland in lieu of a dowry for Margaret of Denmark.

* 1404 – Leon Battista Alberti, Italian painter and philosopher ( d. 1472 )

Fra Bartolomeo or Fra Bartolommeo ( di Pagholo ) ( March 28, 1472 – October 6, 1517 ), also known as Baccio della Porta, was an Italian Renaissance painter of religious subjects.

# 1494 Bianca Maria Sforza ( 1472 – 1510 ), daughter of Duke of Milan Galeazzo Maria Sforza

Lucas Cranach the Elder ( 1472 – 1553 ), the great painter patronized by the electors of Wittenberg, was a close friend of Luther, and illustrated Luther's theology for a popular audience.

Leon Battista Alberti ( February 18, 1404 – April 20, 1472 ) was an Italian author, artist, architect, poet, priest, linguist, philosopher, cryptographer and general Renaissance humanist polymath.

* 1465 – 1472: Mohammed ibn Ali, chief of the Chorfas of Fès, proclaimed sultan in 1465, could impose his rule outside of Fes

* 1472 – 1504: Abou Abd Allah el-Cheikh Mohammed ben Yahya ( fondateur de la dynastie )

The first printed book on pediatrics was in Italian ( 1472 ) – Bagallarder's Little Book on Disease in Children.

The emergence of these thinkers was attributed to the then rising notion in Renaissance Italy expressed by one of its most accomplished representatives, Leon Battista Alberti ( 1404 – 1472 ): that " a man can do all things if he will.

**** daughter Bianca Maria ( 1472 – 1510 ), second wife of Holy Roman Emperor Maximilian I

* Leon Battista Alberti ( 1404 – 1472 ) was an Italian author, artist, architect, poet, linguist, philosopher, and cryptographer, and general Renaissance humanist polymath.

* Hayne van Ghizeghem ( – 1472 or possibly later ; New Grove says he died between 1472 and 1497 ), Flemish composer of the early Renaissance Burgundian School.

* November 19 – Anne de Mowbray, 8th Countess of Norfolk ( b. 1472 )

* December 28 – Piero di Lorenzo de ' Medici, ruler of Florence ( b. 1472 )

* According to Wang Yangming ( 1472 – 1529 ), the Ming Dynasty philosopher and governor of Jiangxi, China, he intends to use fo – lang – ji cannons in suppressing the rebellion of Prince Zhu Chenhao in this year.

Lucas Cranach the Elder ( 1472 – 1553 ), the great painter patronized by the electors of Wittenberg, was a close friend of Luther, and illustrated Luther's theology for a popular audience.