* 1503 – King James IV of Scotland marries Margaret Tudor, daughter of King Henry VII of England at Holyrood Abbey in Edinburgh, Scotland.

* 1503 – Christian III of Denmark ( d. 1559 )

* 1503 – The Battle of Cerignola is fought.

Around 1503 – 1505 he produced the first seventeen of a set illustrating the Life of the Virgin, which he did not finish for some years.

* House of Bourbon ( 1268 – 1503 )

Coming from modest beginnings in Savona, Liguria, the family rose to prominence through nepotism and ambitious marriages arranged by two Della Rovere popes, Francesco della Rovere, who ruled as Pope Sixtus IV ( 1471 – 1484 ) and his nephew Giuliano ( Pope Julius II, 1503 – 1513 ).

* 1503 – Nostradamus, French astrologer ( d. 1566 )

* 1471 – Piero di Lorenzo de ' Medici, Italian ruler ( d. 1503 )

* 1503 – Disfida di Barletta – famous challenge between 13 Italian and 13 French knights near Barletta.

* 1466 – Elizabeth of York, wife of Henry VII of England ( d. 1503 )

* Ferdinand I, Holy Roman Emperor ( 1503 – 1564 )

# Gumprecht ( 16 July 1503, Ansbach – 25 June 1528, Naples ), a canon in Bamberg.

* Andrzej Frycz Modrzewski ( 1503 – 1572 )

# Agnes ( b. Dresden, 7 January 1503 – d. Dresden, 16 April 1503 ).

Mai Ali Gazi ibn Dunama ( c. 1475 – 1503 ) defeated the Bilala, reestablishing complete control of Kanem.

* Ippolita Gonzaga ( 13 November 1503 – 16 March 1570 ), a nun.

* 1503 – Parmigianino, Italian artist ( d. 1540 )

* 1503 – Wilhelm von Grumbach, German adventurer ( d. 1567 )

* 1503 – Anne of Bohemia and Hungary ( d. 1547 )

The Mona Lisa, Leonardo da Vinci, oil on panel, 1503 – 19, probably completed while the artist was at the court of Francis I of France | Francis I.

Mona Lisa or La Gioconda ( 1503 – 1505 / 1507 )— Louvre, Paris, France

* 1446 – Margaret of York, wife of Charles I, Duke of Burgundy ( d. 1503 )

* 1503 in art-Birth of Agnolo di Cosimo

Agnolo di Cosimo ( November 17, 1503 – November 23, 1572 ), usually known as Il Bronzino, or Agnolo Bronzino ( mistaken attempts also have been made in the past to assert his name was Agnolo Tori and even Angelo ( Agnolo ) Allori ), was an Italian Mannerist painter from Florence.

* Bronzino ( proper name Agnolo di Cosimo ), ( 1503 – 1572 ), Florentine painter

The first such recorded example is that of Ludovico di Varthema of Bologna in 1503.

* February 15 – Piero di Lorenzo de ' Medici, ruler of Florence ( d. 1503 )

* August 4 – Lorenzo di Pierfrancesco de ' Medici, Italian patron of the arts ( d. 1503 )

Among these were Hermann, " bacalaurio in medicina ", astrologist Baptista de Vesentio, Maestro Zoano barbero from Genoa ( in 1468 ), Isaac Beg ( in 1473 ), Don Antonio Branca ( skilled in fixing cut noses ), Mateo Muriano from Venice ( in 1502 ), and Hieronimo di Cesena from Venice ( in 1503 ).

* Piero di Lorenzo de ' Medici ( 1471 – 1503 ) ( the Unfortunate, also Piero II de ' Medici ), son of Lorenzo the Magnificent

Lorenzo di Pierfrancesco de ' Medici ( August 4, 1463 – May 20, 1503 ), nicknamed the Popolano, was an Italian banker and politician, and the brother of Giovanni il Popolano.

However, he was defeated in the battle of Ruvo di Puglia ( 1503 ) and made prisoner by Gonzalo Fernández de Córdoba.

In 1503 it was the location of the disfida di Barletta (" Joust of Barletta "), a battle during which 13 Italian knights commanded by Ettore Fieramosca challenged and defeated an equal number of French knights who were at the time prisoners of war, in a joust held near Andria.

Although Burton was not the first non-Muslim European to make the Hajj ( that distinction belonging to Ludovico di Barthema in 1503 ), his pilgrimage is the most famous and the best documented of the time.

# Bianca ( b. Rome, March 1478-d. after 1522 ), married firstly in 1494, Astorre III Manfredi, Lord of Faenza ( d. 1502 ), and secondly in 1503, Troilo Rossi ( d. 1521 ), the first Marchese di San Secondo.

The Travels of Ludovico di Varthema in Egypt, Syria, Arabia Deserta and Arabia Felix, in Persia, India, and Ethiopia, A. D. 1503 to 1508.

The travels of Ludovico di Varthema in Egypt, Syria, Arabia Deserta and Arabia Felix, in Persia, India, and Ethiopia, A. D. 1503 to 1508 ( 1863 ).

The term was first coined by the Florentine explorer Amerigo Vespucci, in a letter written to his patron Lorenzo di Pier Francesco de ' Medici in the Spring of 1503, and published ( in Latin ) in 1503-04 under the title Mundus Novus.

* Cosimo Bartoli ( 1503 – 1572 ), Italian diplomat and humanist

* 1503 – Antonio Francesco Grazzini, Italian writer ( d. 1583 )

The first of them was Rodrigo de Borja (" Borgia " in Italian ), that later became Pope Alexander VI ( 1492 – 1503 ), infamous for his alleged corruption and immorality.

* August 24 – Girolamo Francesco Maria Mazzola, Italian artist ( b. 1503 )

* November 14 – Giovanni della Casa, Italian poet ( b. 1503 )

Iovianus Pontanus ( Italian Giovanni Gioviano Pontano ) ( 1426 – September 17, 1503 ) was an Italian humanist and poet.

* February 18-Antonio Francesco Grazzini, Italian prose writer ( born 1503 )

* Alvise Vivarini ( Italian, 1445 – 1503 )

* Parmigianino ( Italian, 1503 – 1540 ) Mannerist painter / etcher from Parma

* Angelo Bronzino ( Italian, 1503 – 1572 )

At the beginning of the 16th century, during the guerilla war between the French and the Spanish over possession of Southern Italy, the city was the theater of a historical victory of Italian knights over French prisoners, in what became known as the Challenge of Barletta ( 13 February 1503 ).

* Ettore Fieramosca ( 1476 – 1515 ), head of the Italian knights participating in the famous Joust of Barletta in 1503.

Alvise or Luigi Vivarini, ( 1442 / 1453 – 1503 / 1505 ), was an Italian painter, the leading Venetian artist before Giovanni Bellini.

Italian Renaissance painting saw a great increase in military art by the leading artists, battle paintings often featuring near-contemporary scenes such as the huge set of three canvases of The Battle of San Romano ( c. 1445 ) by Paolo Uccello, and the abortive Battle of Cascina ( 1504 – 06 ) by Michelangelo and Battle of Anghiari by Leonardo da Vinci ( 1503 – 06 ), which were intended to be placed opposite each other in the Palazzo Vecchio in Florence, but neither of which were completed.

Antonio Francesco Grazzini ( March 22, 1503 – February 18, 1584 ) was an Italian author.

Antonio Bonfini ( Latin variant: Antonius Bonfinius ) ( 1434 – 1503 ) was an Italian humanist and poet who spent the last years of his career as a court historian in Hungary with King Matthias Corvinus .< ref >