* 1503 – King James IV of Scotland marries Margaret Tudor, daughter of King Henry VII of England at Holyrood Abbey in Edinburgh, Scotland.

* 1503 – Christian III of Denmark ( d. 1559 )

* 1503 – The Battle of Cerignola is fought.

Around 1503 – 1505 he produced the first seventeen of a set illustrating the Life of the Virgin, which he did not finish for some years.

* House of Bourbon ( 1268 – 1503 )

Coming from modest beginnings in Savona, Liguria, the family rose to prominence through nepotism and ambitious marriages arranged by two Della Rovere popes, Francesco della Rovere, who ruled as Pope Sixtus IV ( 1471 – 1484 ) and his nephew Giuliano ( Pope Julius II, 1503 – 1513 ).

* 1503 – Nostradamus, French astrologer ( d. 1566 )

* 1471 – Piero di Lorenzo de ' Medici, Italian ruler ( d. 1503 )

* 1503 – Disfida di Barletta – famous challenge between 13 Italian and 13 French knights near Barletta.

* 1466 – Elizabeth of York, wife of Henry VII of England ( d. 1503 )

* Ferdinand I, Holy Roman Emperor ( 1503 – 1564 )

# Gumprecht ( 16 July 1503, Ansbach – 25 June 1528, Naples ), a canon in Bamberg.

* Andrzej Frycz Modrzewski ( 1503 – 1572 )

# Agnes ( b. Dresden, 7 January 1503 – d. Dresden, 16 April 1503 ).

Mai Ali Gazi ibn Dunama ( c. 1475 – 1503 ) defeated the Bilala, reestablishing complete control of Kanem.

* Ippolita Gonzaga ( 13 November 1503 – 16 March 1570 ), a nun.

* 1503 – Parmigianino, Italian artist ( d. 1540 )

* 1503 – Wilhelm von Grumbach, German adventurer ( d. 1567 )

* 1503 – Anne of Bohemia and Hungary ( d. 1547 )

The Mona Lisa, Leonardo da Vinci, oil on panel, 1503 – 19, probably completed while the artist was at the court of Francis I of France | Francis I.

Mona Lisa or La Gioconda ( 1503 – 1505 / 1507 )— Louvre, Paris, France

* 1446 – Margaret of York, wife of Charles I, Duke of Burgundy ( d. 1503 )

In 1501, the Spanish monarchs, Ferdinand I and Isabella, first granted permission to the colonists of the Caribbean to import African slaves, which began arriving to the island in 1503.

After the fall of the Byzantine Empire, the legitimate heir to the throne, Andreas Palaiologos, willed away his claim to Ferdinand and Isabella in 1503.

In 1503, Queen Isabella ruled that only people who were better off under slavery ( a definition which explicitly included cannibals ) could legally be taken as slaves.

The young prince was sworn heir to the throne in 1503, the year his youngest sister, Isabella of Portugal, Consort Empress of the Holy Roman Empire between 1527 and 1538, was born.

* Isabella of Portugal ( 1503 – 1539 ), Holy Roman Empress to Charles V and his queen consort of Aragon and Castile

The Casa de Contratación was founded by Queen Isabella I of Castile in 1503, eleven years after the discovery of the Americas in 1492.

* Isabella of Portugal ( 1503 – 1539 ), Holy Roman Empress by marriage to Charles V

The Puerto de Indias in Seville became the principal port linking Spain to Latin America in 1503 with the monopoly created by the royal decree of Queen Isabella I of Castile ; this granted the city exclusive privileges as the port of entry and exit for all the Indies trade.

Vasco da Gama arrived back in Portugal in September 1503, effectively having failed in his mission to bring the Zamorin to submission.

1503 – 1515 — Establishment of monopolies on maritime trade routes to the Indian Ocean and Persian Gulf by Afonso de Albuquerque, an admiral, for the benefit of Portugal

The milestone came in Portugal between 1503 and 1526 and symbolizes the power of the Portuguese crown, used to demarcate their land.

He returned to Portugal in September, 1503.

For a short time he lived in peace undisturbed ; but when the city was taken by the French, bereft of all his possessions, he followed the young king, Ferdinand, in 1495, to Messina ; then went to Corfu ; and in 1496 settled in Monopoli, and lastly ( 1503 ) in Venice, where his services were employed in negotiating a commercial treaty between Portugal and the Venetian republic.

Coelho left Portugal for a third time on April 14, 1503 as captain of the " Faial " with the armada of Afonso de Albuquerque, but died while returning home to Portugal in January 1504 along with Francisco de Albuquerque, Afonso's cousin, near the shallows of São Lázaro, modern day Quirimbas Islands, Mozambique.

* 1503 – Portuguese crown the new King of Kochi, effectively making him a vassal of the King of Portugal.

* February 11 – Elizabeth of York, queen of Henry VII of England ( d. 1503 )

* Elizabeth of York, queen consort to Henry VII of England ( 11 February 1466 – 11 February 1503 ).

* Anna of Bohemia and Hungary ( 1503 − 1547 ), queen of Ferdinand I, Holy Roman Emperor, Hungary, Germany and Bohemia

* Elizabeth of York ( 1466 – 1503 ), queen consort of England

In 1501 he joined the household of his half-sister, the queen consort Elizabeth of York, and moved to the household of Henry VII after her death in 1503.