* 1516 – The Treaty of Noyon between France and Spain is signed.

* 1516 – Tabinshwehti, King of Burma ( d. 1550 )

* 1516 – Bayerische Reinheitsgebot signed in Ingolstadt.

Conrad von Gesner ( 1516 – 1565 ) and Nicholas Culpeper ( 1616 – 1654 ) also published herbals covering the medicinal uses of plants.

* Johannes Trithemius ( 1462 – 1516 )

Subsequently, the Druze chiefs of the Gharb placed their considerable military experience at the disposal of the Mamluk rulers of Egypt ( 1250 – 1516 ); first, to assist them in putting an end to what remained of Crusader rule in coastal Syria, and later to help them safeguard the Syrian coast against Crusader retaliation by sea.

* 1516 – Johannes Trithemius, German cryptographer ( b. 1462 )

* 1565 – Conrad Gessner, Swiss naturalist ( b. 1516 )

Martin Luther's lectures on Romans in 1515 – 1516 probably coincided with the development of his criticism of Roman Catholicism which led to the 95 Theses of 1517.

* 1516 – Queen Mary I of England ( d. 1558 )

* 1516 14 March – Spain becomes a united kingdom under Charles I.

The German Abbot and occultist Trithemius ( 1462 – 1516 ) supposedly had in his possession a Book of Simon the Magician, based upon the New Testament figure of Simon Magus.

His third wife was Emilie of Saxony ( July 27, 1516 – March 9, 1591 ), daughter of Henry IV, Duke of Saxony and Catherine of Mecklenburg on August 25, 1533:

# Johann ( b. Dresden, 24 August 1498 – d. Dresden, 11 January 1537 ), Hereditary Duke of Saxony ; married on 20 May 1516 to Elizabeth of Hesse.

His plot failed in a matter of days, Jane Grey was beheaded, and Mary I ( 1516 – 1558 ) took the throne amidst popular demonstration in her favour in London, which contemporaries described as the largest show of affection for a Tudor monarch.

The Mamluk province of Bilad a-Sham ( Syria ) was conquered by Turkish Sultan Selim II in 1516 – 17, becoming a part of the province of Ottoman Syria for the next four centuries, first as the Damascus Eyalet and later as the Syria Vilayet ( following the Tanzimat reorganization of 1864 ).

* Kings of Spain ( 1516 – 1700 ),

* 1516 – Bayinnaung, King of Burma ( d. 1581 )

The Ottoman sultan, Selim I ( 1516 – 20 ), after defeating the Persians, conquered the Mamluks.

Salim I, moved by the eloquence of the Lebanese ruler Amir Fakhr ad Din I ( 1516 – 44 ), decided to grant the Lebanese amirs a semiautonomous status.

* Vladislaus II of Bohemia and Hungary ( 1456 – 1516 ), Jagiellon ruler who was sometimes referred to as Vladislav III of Bohemia

* 1456 – King Ladislaus II of Bohemia and Hungary ( d. 1516 )

* Mary I of England ( 1516 – 1558 ), aka " Bloody Mary ", Queen of England and Ireland

* 1452 – Ferdinand II of Aragon ( d. 1516 )

Important naval victories of the Ottoman Empire in this period include the Battle of Preveza ( 1538 ); Battle of Ponza ( 1552 ); Battle of Djerba ( 1560 ); conquest of Algiers ( in 1516 and 1529 ) and Tunis ( in 1534 and 1574 ) from Spain ; conquest of Rhodes ( 1522 ) and Tripoli ( 1551 ) from the Knights of St. John ; capture of Nice ( 1543 ) from the Holy Roman Empire ; capture of Corsica ( 1553 ) from the Republic of Genoa ; capture of the Balearic Islands ( 1558 ) from Spain ; capture of Aden ( 1548 ), Muscat ( 1552 ) and Aceh ( 1565 – 67 ) from Portugal during the Indian Ocean expeditions ; among others.

* 1516: Selim I defeats the Mamluks at the Battle of Merc-i Dabik and kills Sultan Kansu Gavri ; Syria is conquered.

Saffuriya (, also transliterated Safurriya and Suffurriye ), along with the whole of Palestine, came under the rule of the Ottoman Empire after it defeated the Mamluks at the Battle of Marj Dabiq in 1516.

In November 1516 Hamilton married Janet Bethune of Easter Wemyss, daughter of Sir David Bethune of Creich, and widow of Sir Robert Livingstone of Easter Wemyss, who had been killed in the Battle of Flodden Field.

In late 1516 Khan Yunis was the site of a minor battle in which the Egypt-based Mamluks were defeated by Ottoman forces under the leadership of Sinan Pasha.

In 1516, the Mamluks of Egypt annexed Yemen ; but in the following year, the Mamluk governor surrendered to the Ottomans, and Turkish armies subsequently overran the country.

Frances I, on the other hand, decides on a more simplistic approach and forces the pope to sign the Concordant Of Bologna in 1516, which gave the king power to appoint whomever he wants for bishops and other religious positions and lessened the power of the papacy.

After the battle of Chaldiran, Selim I would then throw his forces southward to fight the Mamluk Sultanate in the Ottoman – Mamluk War ( 1516 – 1517 ).

The involvement of the Old Swiss Confederacy, acting in its own interests in these wars, was brought to an end by the defeat against French forces in the battle of Marignano in 1515 and a subsequent peace treaty with the French king in 1516, the so-called Eternal Peace.

Melting of styles occurred during the period when the Holy Roman Empire and Burgundy were part of the dominions under Charles I ( king of Spain from 1516 to 1556 ), since composers from the North both visited Spain, and native Spaniards travelled within the empire, which extended to the Netherlands, Germany and Italy.

In 1516, the secular prince Đurađ V Crnojević abdicated in favor of the Archbishop Vavil, who then formed Montenegro into a theocratic state under the rule of the prince-bishop ( vladika ) of Cetinje, a position transmitted from 1697 by the Petrović-Njegoš family of the Riđani clan, from uncle to nephew as the bishops were not allowed to marry.

Latakia came under Ottoman control after 1516 and was part of Ottoman Syria.

This was not a purchase on behalf of the society and after a five year delay, it was transferred under the will of Denys in 1516 to the Carthusian House of Jesus of Bethlehem ( Sheen Priory ), which remained the Society's landlord until 1539, when the Second Act of Dissolution led to the Dissolution of the Monasteries and passed ownership of the Inn to the Crown.

Rodrigo de Santaello, archdeacon of the cathedral and commonly known as Maese Rodrigo, began the construction of a building for a university in 1472 ; in 1502 the Catholic Monarchs published the royal decree creating the university, and in 1505 Julius II granted the Bull of authorization ; in 1509 the college of Maese Rodrigo was finally installed in its own building, under the name of Santa María de Jesús, but its courses were not opened until 1516.

* 1516: Royal Mail established by Henry VIII under Master of the Posts.

Although the Palais remained under papal control ( along with the surrounding city and Comtat Venaissin ) for over 350 years afterwards, it gradually deteriorated despite a restoration in 1516.

On 14 March 1516 Charles V was proclaimed King of Castile and of Aragon jointly with his mother, the first time the crowns of Castile and Aragon were united under the same king.

HLA is defined under IEEE Standard 1516:

The IEEE 1516 standard has been revised under the SISO HLA-Evolved Product Development Group and was approved 25-Mar-2010 by the IEEE Standards Activities Board.

In the early 16th century, it was for a time occupied by the Safavids, before coming under Ottoman control in 1516.

The war was less of a success than that against Venice, and in 1516 France agreed to a truce that left Milan under French control and recognized Spanish hegemony in northern Navarre.

In 1516, the secular montenegrin prince Đurađ V Crnojević abdicated in favor of the Archbishop Vavil, who then formed Montenegro into a theocratic state under the rule of the prince-bishop ( vladika ) of Cetinje, a position transmitted from 1697 by the Petrović-Njegoš family of the Riđani clan, from uncle to nephew as the bishops were not allowed to marry.

Only briefly, was Lonato under Mantuan rule under the marquis Francesco Gonzaga ( 1509 – 1516 ).

This category lists people whose Judaism is notable and are / were of Palestine ( covering present-day Jordan, Israel the West Bank and Gaza Strip and parts of Syria ) under the Ottoman Empire from 1516 to 1917 and under British rule from 1917 until 1948.

Raphael gave the chapel a centralized octagonal plan, under a dome decorated with mosaics to his cartoon ( 1516 ), representing the Creation of the World surrounded by the sun and the six know planets and a zodiac, each moved by an angel ; it is a rare example of mosaic executed to a High Renaissance design.

It passed, on their forfeiture in 1516, to the Douglas Earl of Angus, but was besieged and destroyed by the English under the Henry Percy, 6th Earl of Northumberland in the winter of 1532, and again under the Protector Somerset in 1547, when held by Sir George Douglas.

He is known to have been active, and already well-established, in Augsburg from c. 1516, where he was working, and signing the reverse of blocks, under Jost de Negker, the other great blockcutter of the period, on the print projects for Maximilian I, Holy Roman Emperor involving Albrecht Dürer, Hans Burgkmair and other artists.